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66 similar compounds to monomer 50444135

Compile data set for download or QSAR
Wt: 360.4
BDBM50321421
Wt: 345.3
BDBM50321423
Wt: 374.4
BDBM50321426
Wt: 402.4
BDBM50321427
Wt: 416.4
BDBM50321428
Wt: 464.5
BDBM50321429
Wt: 432.4
BDBM50321430
Wt: 445.5
BDBM50321431
Wt: 459.5
BDBM50321432
Wt: 418.4
BDBM50321433
Wt: 418.4
BDBM50321435
Wt: 388.4
BDBM50382442
Wt: 390.4
BDBM50384004
Wt: 376.4
BDBM50384006
Wt: 446.5
BDBM50384008
Displayed 1 to 15 (of 66 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50321421,50321423,50321426,50321427,50321428,50321429,50321430,50321431,50321432,50321433,50321435,50382442,50384004,50384006,50384008   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382442
PNG
(CHEMBL2023350)
Show SMILES CN1CCC(CC1)n1cc(c(C)n1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H24N6O/c1-14-18(13-28(26-14)16-7-9-27(2)10-8-16)15-11-17(21(23)24-12-15)22-25-19-5-3-4-6-20(19)29-22/h3-6,11-13,16H,7-10H2,1-2H3,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


ACS Med Chem Lett 2: 907-912 (2011)


Article DOI: 10.1021/ml200198x
BindingDB Entry DOI: 10.7270/Q2DZ099R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321423
PNG
(2-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-3...)
Show SMILES C1CC(CCN1)n1cc(cn1)-c1cncc(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C20H19N5O/c1-2-4-19-18(3-1)24-20(26-19)15-9-14(10-22-11-15)16-12-23-25(13-16)17-5-7-21-8-6-17/h1-4,9-13,17,21H,5-8H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321426
PNG
(3-(benzo[d]oxazol-2-yl)-N-methyl-5-(1-(piperidin-4...)
Show SMILES CNc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O/c1-22-20-17(21-26-18-4-2-3-5-19(18)28-21)10-14(11-24-20)15-12-25-27(13-15)16-6-8-23-9-7-16/h2-5,10-13,16,23H,6-9H2,1H3,(H,22,24)
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Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321427
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O2/c1-14(29)27-8-6-17(7-9-27)28-13-16(12-25-28)15-10-18(21(23)24-11-15)22-26-19-4-2-3-5-20(19)30-22/h2-5,10-13,17H,6-9H2,1H3,(H2,23,24)
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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321428
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CCC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H24N6O2/c1-2-21(30)28-9-7-17(8-10-28)29-14-16(13-26-29)15-11-18(22(24)25-12-15)23-27-19-5-3-4-6-20(19)31-23/h3-6,11-14,17H,2,7-10H2,1H3,(H2,24,25)
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n/an/a 7n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321429
PNG
((4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H24N6O2/c28-25-22(26-31-23-8-4-5-9-24(23)35-26)14-19(15-29-25)20-16-30-33(17-20)21-10-12-32(13-11-21)27(34)18-6-2-1-3-7-18/h1-9,14-17,21H,10-13H2,(H2,28,29)
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n/an/a 140n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321430
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES COCC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H24N6O3/c1-31-14-21(30)28-8-6-17(7-9-28)29-13-16(12-26-29)15-10-18(22(24)25-11-15)23-27-19-4-2-3-5-20(19)32-23/h2-5,10-13,17H,6-9,14H2,1H3,(H2,24,25)
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n/an/a 17n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321431
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H27N7O2/c1-29(2)15-22(32)30-9-7-18(8-10-30)31-14-17(13-27-31)16-11-19(23(25)26-12-16)24-28-20-5-3-4-6-21(20)33-24/h3-6,11-14,18H,7-10,15H2,1-2H3,(H2,25,26)
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n/an/a 60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321432
PNG
(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-yl)...)
Show SMILES CCN(CC)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H29N7O2/c1-3-30(4-2)25(33)31-11-9-19(10-12-31)32-16-18(15-28-32)17-13-20(23(26)27-14-17)24-29-21-7-5-6-8-22(21)34-24/h5-8,13-16,19H,3-4,9-12H2,1-2H3,(H2,26,27)
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n/an/a 357n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321433
PNG
(CHEMBL1169794 | methyl 4-(4-(6-amino-5-(benzo[d]ox...)
Show SMILES COC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O3/c1-30-22(29)27-8-6-16(7-9-27)28-13-15(12-25-28)14-10-17(20(23)24-11-14)21-26-18-4-2-3-5-19(18)31-21/h2-5,10-13,16H,6-9H2,1H3,(H2,23,24)
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n/an/a 58n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321435
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C22H22N6O3/c23-21-17(22-26-18-3-1-2-4-19(18)31-22)9-14(10-24-21)15-11-25-28(12-15)16-5-7-27(8-6-16)20(30)13-29/h1-4,9-12,16,29H,5-8,13H2,(H2,23,24)
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n/an/a 26n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
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n/an/a 750n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384004
PNG
(CHEMBL2032276)
Show SMILES Cc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-19-17(8-18(12)28)26-21(29-19)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 27n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
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n/an/a 80n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Ron


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384008
PNG
(CHEMBL2032296)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2c(C)c(O)c(C)cc2o1
Show InChI InChI=1S/C24H26N6O3/c1-13-8-20-21(14(2)22(13)32)28-24(33-20)19-9-16(10-26-23(19)25)17-11-27-30(12-17)18-4-6-29(7-5-18)15(3)31/h8-12,18,32H,4-7H2,1-3H3,(H2,25,26)
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n/an/a 28n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 19n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384004
PNG
(CHEMBL2032276)
Show SMILES Cc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-19-17(8-18(12)28)26-21(29-19)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 2n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
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n/an/a 80n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair