BindingDB logo
myBDB logout

49 similar compounds to monomer 50444107

Compile data set for download or QSAR
Wt: 360.4
BDBM50321421
Wt: 374.4
BDBM50321426
Wt: 402.4
BDBM50321427
Wt: 416.4
BDBM50321428
Wt: 432.4
BDBM50321430
Wt: 445.5
BDBM50321431
Wt: 459.5
BDBM50321432
Wt: 418.4
BDBM50321433
Wt: 418.4
BDBM50321435
Wt: 376.4
BDBM50384006
Wt: 436.8
BDBM50384010
Wt: 422.4
BDBM50384011
Wt: 392.4
BDBM50384012
Wt: 572.6
BDBM50384014
Wt: 469.5
BDBM50384015
Displayed 1 to 15 (of 49 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50321421,50321426,50321427,50321428,50321430,50321431,50321432,50321433,50321435,50384006,50384010,50384011,50384012,50384014,50384015   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor kinase 5


(Homo sapiens (Human))
BDBM50384014
PNG
(CHEMBL2032290)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H28N8O4S/c1-17-2-5-22(6-3-17)41(38,39)35-28(37)33-20-4-7-24-25(13-20)40-27(34-24)23-12-18(14-31-26(23)29)19-15-32-36(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H2,33,35,37)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 880n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50384014
PNG
(CHEMBL2032290)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H28N8O4S/c1-17-2-5-22(6-3-17)41(38,39)35-28(37)33-20-4-7-24-25(13-20)40-27(34-24)23-12-18(14-31-26(23)29)19-15-32-36(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H2,33,35,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))
BDBM50384015
PNG
(CHEMBL2032289)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O/c27-18-1-3-19(4-2-18)32-20-5-6-23-24(12-20)35-26(33-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)21-7-9-29-10-8-21/h1-6,11-15,21,29,32H,7-10H2,(H2,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321426
PNG
(3-(benzo[d]oxazol-2-yl)-N-methyl-5-(1-(piperidin-4...)
Show SMILES CNc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O/c1-22-20-17(21-26-18-4-2-3-5-19(18)28-21)10-14(11-24-20)15-12-25-27(13-15)16-6-8-23-9-7-16/h2-5,10-13,16,23H,6-9H2,1H3,(H,22,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321427
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O2/c1-14(29)27-8-6-17(7-9-27)28-13-16(12-25-28)15-10-18(21(23)24-11-15)22-26-19-4-2-3-5-20(19)30-22/h2-5,10-13,17H,6-9H2,1H3,(H2,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321428
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CCC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H24N6O2/c1-2-21(30)28-9-7-17(8-10-28)29-14-16(13-26-29)15-11-18(22(24)25-12-15)23-27-19-5-3-4-6-20(19)31-23/h3-6,11-14,17H,2,7-10H2,1H3,(H2,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321430
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES COCC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H24N6O3/c1-31-14-21(30)28-8-6-17(7-9-28)29-13-16(12-26-29)15-10-18(22(24)25-11-15)23-27-19-4-2-3-5-20(19)32-23/h2-5,10-13,17H,6-9,14H2,1H3,(H2,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321431
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H27N7O2/c1-29(2)15-22(32)30-9-7-18(8-10-30)31-14-17(13-27-31)16-11-19(23(25)26-12-16)24-28-20-5-3-4-6-21(20)33-24/h3-6,11-14,18H,7-10,15H2,1-2H3,(H2,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321432
PNG
(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-yl)...)
Show SMILES CCN(CC)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H29N7O2/c1-3-30(4-2)25(33)31-11-9-19(10-12-31)32-16-18(15-28-32)17-13-20(23(26)27-14-17)24-29-21-7-5-6-8-22(21)34-24/h5-8,13-16,19H,3-4,9-12H2,1-2H3,(H2,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 357n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321433
PNG
(CHEMBL1169794 | methyl 4-(4-(6-amino-5-(benzo[d]ox...)
Show SMILES COC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O3/c1-30-22(29)27-8-6-16(7-9-27)28-13-15(12-25-28)14-10-17(20(23)24-11-14)21-26-18-4-2-3-5-19(18)31-21/h2-5,10-13,16H,6-9H2,1H3,(H2,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 58n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321435
PNG
(1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C22H22N6O3/c23-21-17(22-26-18-3-1-2-4-19(18)31-22)9-14(10-24-21)15-11-25-28(12-15)16-5-7-27(8-6-16)20(30)13-29/h1-4,9-12,16,29H,5-8,13H2,(H2,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-MET by HTRF assay


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 750n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells


Bioorg Med Chem Lett 20: 4223-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.031
BindingDB Entry DOI: 10.7270/Q2JW8FTQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
PDB

KEGG

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Ron


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384010
PNG
(CHEMBL2032294)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C22H21ClN6O2/c1-13(30)28-6-4-17(5-7-28)29-12-15(11-26-29)14-8-18(21(24)25-10-14)22-27-19-3-2-16(23)9-20(19)31-22/h2-3,8-12,17H,4-7H2,1H3,(H2,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384011
PNG
(CHEMBL2032293)
Show SMILES Nc1ncc(cc1-c1nc2ccc(F)cc2o1)-c1cnn(c1)C1CCN(CCO)CC1
Show InChI InChI=1S/C22H23FN6O2/c23-16-1-2-19-20(10-16)31-22(27-19)18-9-14(11-25-21(18)24)15-12-26-29(13-15)17-3-5-28(6-4-17)7-8-30/h1-2,9-13,17,30H,3-8H2,(H2,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384012
PNG
(CHEMBL2032292)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccc(F)cc2o1
Show InChI InChI=1S/C21H21FN6O/c1-27-6-4-16(5-7-27)28-12-14(11-25-28)13-8-17(20(23)24-10-13)21-26-18-3-2-15(22)9-19(18)29-21/h2-3,8-12,16H,4-7H2,1H3,(H2,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384014
PNG
(CHEMBL2032290)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H28N8O4S/c1-17-2-5-22(6-3-17)41(38,39)35-28(37)33-20-4-7-24-25(13-20)40-27(34-24)23-12-18(14-31-26(23)29)19-15-32-36(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H2,33,35,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384015
PNG
(CHEMBL2032289)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O/c27-18-1-3-19(4-2-18)32-20-5-6-23-24(12-20)35-26(33-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)21-7-9-29-10-8-21/h1-6,11-15,21,29,32H,7-10H2,(H2,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
G protein-coupled receptor kinase 5


(Homo sapiens (Human))
BDBM50384015
PNG
(CHEMBL2032289)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O/c27-18-1-3-19(4-2-18)32-20-5-6-23-24(12-20)35-26(33-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)21-7-9-29-10-8-21/h1-6,11-15,21,29,32H,7-10H2,(H2,28,30)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair