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4 similar compounds to monomer 50327448

Wt: 306.3
BDBM50327445
Wt: 336.3
BDBM50327446
Wt: 308.2
BDBM50327449
Wt: 324.2
BDBM50327450

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50327445,50327446,50327449,50327450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
phosphatase Cdc25


(Homo sapiens (Human))
BDBM50327445
PNG
(7-methoxy-4-(3-oxo-3-phenylprop-1-enyl)-2H-chromen...)
Show SMILES COc1ccc2c(\C=C\C(=O)c3ccccc3)cc(=O)oc2c1
Show InChI InChI=1S/C19H14O4/c1-22-15-8-9-16-14(11-19(21)23-18(16)12-15)7-10-17(20)13-5-3-2-4-6-13/h2-12H,1H3/b10-7+
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n/an/a 2.70E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25A expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
phosphatase Cdc25


(Homo sapiens (Human))
BDBM50327446
PNG
(7-methoxy-4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)...)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc(=O)oc2cc(OC)ccc12
Show InChI InChI=1S/C20H16O5/c1-23-15-6-3-13(4-7-15)18(21)10-5-14-11-20(22)25-19-12-16(24-2)8-9-17(14)19/h3-12H,1-2H3/b10-5+
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n/an/a 7.00E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25A expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
phosphatase Cdc25


(Homo sapiens (Human))
BDBM50327449
PNG
(7-hydroxy-4-(3-(4-hydroxyphenyl)-3-oxoprop-1-enyl)...)
Show SMILES Oc1ccc(cc1)C(=O)\C=C\c1cc(=O)oc2cc(O)ccc12
Show InChI InChI=1S/C18H12O5/c19-13-4-1-11(2-5-13)16(21)8-3-12-9-18(22)23-17-10-14(20)6-7-15(12)17/h1-10,19-20H/b8-3+
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n/an/a 9.60E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25A expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327450
PNG
(4-(3-(3,4-dihydroxyphenyl)-3-oxoprop-1-enyl)-7-hyd...)
Show SMILES Oc1ccc2c(\C=C\C(=O)c3ccc(O)c(O)c3)cc(=O)oc2c1
Show InChI InChI=1S/C18H12O6/c19-12-3-4-13-10(8-18(23)24-17(13)9-12)1-5-14(20)11-2-6-15(21)16(22)7-11/h1-9,19,21-22H/b5-1+
PDB
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n/an/a 7.20E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327445
PNG
(7-methoxy-4-(3-oxo-3-phenylprop-1-enyl)-2H-chromen...)
Show SMILES COc1ccc2c(\C=C\C(=O)c3ccccc3)cc(=O)oc2c1
Show InChI InChI=1S/C19H14O4/c1-22-15-8-9-16-14(11-19(21)23-18(16)12-15)7-10-17(20)13-5-3-2-4-6-13/h2-12H,1H3/b10-7+
PDB
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PubMed
n/an/a 4.90E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327446
PNG
(7-methoxy-4-(3-(4-methoxyphenyl)-3-oxoprop-1-enyl)...)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc(=O)oc2cc(OC)ccc12
Show InChI InChI=1S/C20H16O5/c1-23-15-6-3-13(4-7-15)18(21)10-5-14-11-20(22)25-19-12-16(24-2)8-9-17(14)19/h3-12H,1-2H3/b10-5+
PDB
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Article
PubMed
n/an/a 4.70E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
Cdc25C


(Homo sapiens (Human))
BDBM50327449
PNG
(7-hydroxy-4-(3-(4-hydroxyphenyl)-3-oxoprop-1-enyl)...)
Show SMILES Oc1ccc(cc1)C(=O)\C=C\c1cc(=O)oc2cc(O)ccc12
Show InChI InChI=1S/C18H12O5/c19-13-4-1-11(2-5-13)16(21)8-3-12-9-18(22)23-17-10-14(20)6-7-15(12)17/h1-10,19-20H/b8-3+
PDB
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Article
PubMed
n/an/a>1.50E+5n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair
phosphatase Cdc25


(Homo sapiens (Human))
BDBM50327450
PNG
(4-(3-(3,4-dihydroxyphenyl)-3-oxoprop-1-enyl)-7-hyd...)
Show SMILES Oc1ccc2c(\C=C\C(=O)c3ccc(O)c(O)c3)cc(=O)oc2c1
Show InChI InChI=1S/C18H12O6/c19-12-3-4-13-10(8-18(23)24-17(13)9-12)1-5-14(20)11-2-6-15(21)16(22)7-11/h1-9,19,21-22H/b5-1+
PDB
MMDB

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Article
PubMed
n/an/a 6.20E+4n/an/an/an/an/an/a



Université Paul Verlaine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25A expressed in bacterial expression system after 2 hrs


Bioorg Med Chem Lett 20: 5827-30 (2010)

More data for this
Ligand-Target Pair