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14 similar compounds to monomer 50329449

Compile data set for download or QSAR
Wt: 263.2
BDBM50329418
Wt: 281.2
BDBM50329425
Wt: 277.3
BDBM50329431
Wt: 264.2
BDBM50329434
Wt: 201.2
BDBM50329450
Wt: 293.3
BDBM50329414
Wt: 215.2
BDBM50329454
Wt: 278.3
BDBM50329456
Wt: 288.3
BDBM50329459
Wt: 308.2
BDBM50329460
Wt: 288.3
BDBM50329461
Wt: 342.1
BDBM50329467
Wt: 281.2
BDBM50329415
Wt: 342.1
BDBM50329470

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50329418,50329425,50329431,50329434,50329450,50329414,50329454,50329456,50329459,50329460,50329461,50329467,50329415,50329470   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329456
PNG
(5-(2-Amino-pyridin-4-yl)-2-phenyl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)c1
Show InChI InChI=1S/C16H14N4O/c17-14-8-11(6-7-19-14)13-9-12(16(18)21)15(20-13)10-4-2-1-3-5-10/h1-9,20H,(H2,17,19)(H2,18,21)
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n/an/a 136n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329434
PNG
(2,5-Dipyridin-4-yl-1H-pyrrole-3-carboxamide | CHEM...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccncc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-9,19H,(H2,16,20)
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n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329460
PNG
(2-(4-Nitro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(cc1)[N+]([O-])=O)-c1ccncc1
Show InChI InChI=1S/C16H12N4O3/c17-16(21)13-9-14(10-5-7-18-8-6-10)19-15(13)11-1-3-12(4-2-11)20(22)23/h1-9,19H,(H2,17,21)
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n/an/a 117n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329467
PNG
(2-(4-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Br)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a 73n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329470
PNG
(2-(3-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Br)c1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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n/an/a 56n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329431
PNG
(5-Pyridin-4-yl-2-p-tolyl-1H-pyrrole-3-carboxamide ...)
Show SMILES Cc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-2-4-13(5-3-11)16-14(17(18)21)10-15(20-16)12-6-8-19-9-7-12/h2-10,20H,1H3,(H2,18,21)
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n/an/a 6n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329434
PNG
(2,5-Dipyridin-4-yl-1H-pyrrole-3-carboxamide | CHEM...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccncc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-9,19H,(H2,16,20)
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n/an/a 2n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329461
PNG
(2-(3-Cyano-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)C#N)-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c18-10-11-2-1-3-13(8-11)16-14(17(19)22)9-15(21-16)12-4-6-20-7-5-12/h1-9,21H,(H2,19,22)
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n/an/a 216n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329459
PNG
(2-(2-Cyano-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1C#N)-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c18-10-12-3-1-2-4-13(12)16-14(17(19)22)9-15(21-16)11-5-7-20-8-6-11/h1-9,21H,(H2,19,22)
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n/an/a 131n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329425
PNG
(2-(3-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(F)c1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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n/an/a 23n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329418
PNG
(2-Phenyl-5-pyridin-4-yl-1H-pyrrole-3-carboxamide |...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O/c17-16(20)13-10-14(11-6-8-18-9-7-11)19-15(13)12-4-2-1-3-5-12/h1-10,19H,(H2,17,20)
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n/an/a 9n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329454
PNG
(2-Ethyl-5-pyridin-4-yl-1H-pyrrole-3-carboxamide | ...)
Show SMILES CCc1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C12H13N3O/c1-2-10-9(12(13)16)7-11(15-10)8-3-5-14-6-4-8/h3-7,15H,2H2,1H3,(H2,13,16)
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n/an/a 482n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329450
PNG
(2-Methyl-5-pyridin-4-yl-1H-pyrrole-3-carboxamide |...)
Show SMILES Cc1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C11H11N3O/c1-7-9(11(12)15)6-10(14-7)8-2-4-13-5-3-8/h2-6,14H,1H3,(H2,12,15)
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n/an/a 516n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329414
PNG
(2-(4-Methoxy-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-c...)
Show SMILES COc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-4-2-12(3-5-13)16-14(17(18)21)10-15(20-16)11-6-8-19-9-7-11/h2-10,20H,1H3,(H2,18,21)
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n/an/a 23n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329418
PNG
(2-Phenyl-5-pyridin-4-yl-1H-pyrrole-3-carboxamide |...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O/c17-16(20)13-10-14(11-6-8-18-9-7-11)19-15(13)12-4-2-1-3-5-12/h1-10,19H,(H2,17,20)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329425
PNG
(2-(3-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(F)c1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329415
PNG
(2-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329470
PNG
(2-(3-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Br)c1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329467
PNG
(2-(4-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Br)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329431
PNG
(5-Pyridin-4-yl-2-p-tolyl-1H-pyrrole-3-carboxamide ...)
Show SMILES Cc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-2-4-13(5-3-11)16-14(17(18)21)10-15(20-16)12-6-8-19-9-7-12/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329414
PNG
(2-(4-Methoxy-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-c...)
Show SMILES COc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-4-2-12(3-5-13)16-14(17(18)21)10-15(20-16)11-6-8-19-9-7-11/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329460
PNG
(2-(4-Nitro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(cc1)[N+]([O-])=O)-c1ccncc1
Show InChI InChI=1S/C16H12N4O3/c17-16(21)13-9-14(10-5-7-18-8-6-10)19-15(13)11-1-3-12(4-2-11)20(22)23/h1-9,19H,(H2,17,21)
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n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329461
PNG
(2-(3-Cyano-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)C#N)-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c18-10-11-2-1-3-13(8-11)16-14(17(19)22)9-15(21-16)12-4-6-20-7-5-12/h1-9,21H,(H2,19,22)
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n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329415
PNG
(2-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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Article
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n/an/a 14n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair