BindingDB logo
myBDB logout

18 similar compounds to monomer 50329427

Compile data set for download or QSAR
Wt: 313.7
BDBM50329420
Wt: 335.3
BDBM50329421
Wt: 307.3
BDBM50329422
Wt: 313.7
BDBM50329424
Wt: 297.2
BDBM50329426
Wt: 369.4
BDBM50329435
Wt: 321.3
BDBM50329436
Wt: 293.3
BDBM50329437
Wt: 305.3
BDBM50329441
Wt: 323.3
BDBM50329443
Wt: 280.2
BDBM50329444
Wt: 329.3
BDBM50329448
Wt: 329.3
BDBM50329452
Wt: 293.3
BDBM50329453
Wt: 355.3
BDBM50329463
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50329420,50329421,50329422,50329424,50329426,50329435,50329436,50329437,50329441,50329443,50329444,50329448,50329452,50329453,50329463   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329435
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h1-13,26H,14H2,(H,25,28)(H2,23,24,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329424
PNG
(5-(2-aminopyrimidin-4-yl)-4-chloro-2-phenyl-1H-pyr...)
Show SMILES NC(=O)c1c(Cl)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-11-10(14(17)22)12(8-4-2-1-3-5-8)21-13(11)9-6-7-19-15(18)20-9/h1-7,21H,(H2,17,22)(H2,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329436
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CC(C)NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H19N5O/c1-11(2)21-17(24)13-10-15(14-8-9-20-18(19)23-14)22-16(13)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H,21,24)(H2,19,20,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329421
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzo[b]thiophen-5-yl...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2sccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5OS/c18-16(23)11-8-13(12-3-5-20-17(19)22-12)21-15(11)10-1-2-14-9(7-10)4-6-24-14/h1-8,21H,(H2,18,23)(H2,19,20,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 82n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329420
PNG
(5-(2-amino-5-chloropyrimidin-4-yl)-2-p-tolyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Cl
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329444
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-pyridin-2-yl-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccn1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12N6O/c15-13(21)8-7-11(9-4-6-18-14(16)20-9)19-12(8)10-3-1-2-5-17-10/h1-7,19H,(H2,15,21)(H2,16,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 412n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329448
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-2-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2ccccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-7-8-22-19(21)24-15)23-17(14)13-6-5-11-3-1-2-4-12(11)9-13/h1-10,23H,(H2,20,25)(H2,21,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 269n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329452
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-1-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc2ccccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-8-9-22-19(21)24-15)23-17(14)13-7-3-5-11-4-1-2-6-12(11)13/h1-10,23H,(H2,20,25)(H2,21,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 325n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50329463
PNG
(2-Phenyl-5-(2-phenylamino-pyrimidin-4-yl)-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-13-18(25-19(16)14-7-3-1-4-8-14)17-11-12-23-21(26-17)24-15-9-5-2-6-10-15/h1-13,25H,(H2,22,27)(H,23,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a<1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329443
PNG
(5-(2-Aminopyrimidin-4-yl)-1-(2-hydroxyethyl)-2-phe...)
Show SMILES NC(=O)c1cc(-c2ccnc(N)n2)n(CCO)c1-c1ccccc1
Show InChI InChI=1S/C17H17N5O2/c18-16(24)12-10-14(13-6-7-20-17(19)21-13)22(8-9-23)15(12)11-4-2-1-3-5-11/h1-7,10,23H,8-9H2,(H2,18,24)(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 456n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329437
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CNC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-18-15(22)11-9-13(12-7-8-19-16(17)21-12)20-14(11)10-5-3-2-4-6-10/h2-9,20H,1H3,(H,18,22)(H2,17,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329424
PNG
(5-(2-aminopyrimidin-4-yl)-4-chloro-2-phenyl-1H-pyr...)
Show SMILES NC(=O)c1c(Cl)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-11-10(14(17)22)12(8-4-2-1-3-5-8)21-13(11)9-6-7-19-15(18)20-9/h1-7,21H,(H2,17,22)(H2,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329463
PNG
(2-Phenyl-5-(2-phenylamino-pyrimidin-4-yl)-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-13-18(25-19(16)14-7-3-1-4-8-14)17-11-12-23-21(26-17)24-15-9-5-2-6-10-15/h1-13,25H,(H2,22,27)(H,23,24,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 53n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329441
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-4-vinyl-1H-pyr...)
Show SMILES NC(=O)c1c(C=C)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H15N5O/c1-2-11-13(16(18)23)14(10-6-4-3-5-7-10)22-15(11)12-8-9-20-17(19)21-12/h2-9,22H,1H2,(H2,18,23)(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.15E+3n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329453
PNG
(5-(2-Amino-pyrimidin-4-yl)-1-methyl-2-phenyl-1H-py...)
Show SMILES Cn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-21-13(12-7-8-19-16(18)20-12)9-11(15(17)22)14(21)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,22)(H2,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329422
PNG
(5-(2-Amino-pyrimidin-4-yl)-1-ethyl-2-phenyl-1H-pyr...)
Show SMILES CCn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-2-22-14(13-8-9-20-17(19)21-13)10-12(16(18)23)15(22)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H2,18,23)(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329452
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-1-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc2ccccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-8-9-22-19(21)24-15)23-17(14)13-7-3-5-11-4-1-2-6-12(11)13/h1-10,23H,(H2,20,25)(H2,21,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329448
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-2-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2ccccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-7-8-22-19(21)24-15)23-17(14)13-6-5-11-3-1-2-4-12(11)9-13/h1-10,23H,(H2,20,25)(H2,21,22,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329444
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-pyridin-2-yl-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccn1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12N6O/c15-13(21)8-7-11(9-4-6-18-14(16)20-9)19-12(8)10-3-1-2-5-17-10/h1-7,19H,(H2,15,21)(H2,16,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329421
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzo[b]thiophen-5-yl...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2sccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5OS/c18-16(23)11-8-13(12-3-5-20-17(19)22-12)21-15(11)10-1-2-14-9(7-10)4-6-24-14/h1-8,21H,(H2,18,23)(H2,19,20,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329463
PNG
(2-Phenyl-5-(2-phenylamino-pyrimidin-4-yl)-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-13-18(25-19(16)14-7-3-1-4-8-14)17-11-12-23-21(26-17)24-15-9-5-2-6-10-15/h1-13,25H,(H2,22,27)(H,23,24,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329422
PNG
(5-(2-Amino-pyrimidin-4-yl)-1-ethyl-2-phenyl-1H-pyr...)
Show SMILES CCn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-2-22-14(13-8-9-20-17(19)21-13)10-12(16(18)23)15(22)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H2,18,23)(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329437
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CNC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-18-15(22)11-9-13(12-7-8-19-16(17)21-12)20-14(11)10-5-3-2-4-6-10/h2-9,20H,1H3,(H,18,22)(H2,17,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329436
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CC(C)NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H19N5O/c1-11(2)21-17(24)13-10-15(14-8-9-20-18(19)23-14)22-16(13)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H,21,24)(H2,19,20,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329435
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h1-13,26H,14H2,(H,25,28)(H2,23,24,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329420
PNG
(5-(2-amino-5-chloropyrimidin-4-yl)-2-p-tolyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Cl
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329441
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-4-vinyl-1H-pyr...)
Show SMILES NC(=O)c1c(C=C)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H15N5O/c1-2-11-13(16(18)23)14(10-6-4-3-5-7-10)22-15(11)12-8-9-20-17(19)21-12/h2-9,22H,1H2,(H2,18,23)(H2,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (Human))
BDBM50329426
PNG
(5-(2-Amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1F
Show InChI InChI=1S/C15H12FN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


US Patent US9670191 (2017)


BindingDB Entry DOI: 10.7270/Q2X63K3K
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50329426
PNG
(5-(2-Amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1F
Show InChI InChI=1S/C15H12FN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of Cdc7


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair