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4 similar compounds to monomer 50330718

Compile data set for download or QSAR
Wt: 307.7
BDBM50330709
Wt: 333.7
BDBM50330715
Wt: 346.8
BDBM50330716
Wt: 289.7
BDBM50330704

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330709,50330715,50330716,50330704   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330709
PNG
(2-(2-chloro-4-fluorophenyl)-4,5-dimethyl-1H-pyrazo...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C14H11ClFN3O2/c1-7-13-10(6-12(20)18(7)2)17-19(14(13)21)11-4-3-8(16)5-9(11)15/h3-6,17H,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
213n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330704
PNG
(2-(2-chlorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C14H12ClN3O2/c1-8-13-10(7-12(19)17(8)2)16-18(14(13)20)11-6-4-3-5-9(11)15/h3-7,16H,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
215n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330716
PNG
(2-(2-chlorophenyl)-5-(2-(dimethylamino)ethyl)-4-me...)
Show SMILES CN(C)CCn1c(C)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C17H19ClN4O2/c1-11-16-13(10-15(23)21(11)9-8-20(2)3)19-22(17(16)24)14-7-5-4-6-12(14)18/h4-7,10,19H,8-9H2,1-3H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
235n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330715
PNG
(2-(2-chlorophenyl)-5-(3-hydroxypropyl)-4-methyl-1H...)
Show SMILES Cc1n(CCCO)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C16H16ClN3O3/c1-10-15-12(9-14(22)19(10)7-4-8-21)18-20(16(15)23)13-6-3-2-5-11(13)17/h2-3,5-6,9,18,21H,4,7-8H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
565n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair