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5 similar compounds to monomer 50330722

Compile data set for download or QSAR
Wt: 477.9
BDBM50330720
Wt: 451.9
BDBM50330723
Wt: 384.7
BDBM50330733
Wt: 346.3
BDBM50330734
Wt: 417.8
BDBM50330735

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50330720,50330723,50330733,50330734,50330735   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330734
PNG
(4-Methyl-2-(2-methylphenyl)-5-(pyridine-2-ylmethyl...)
Show SMILES Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccn3)c(C)c2c1=O
Show InChI InChI=1S/C20H18N4O2/c1-13-7-3-4-9-17(13)24-20(26)19-14(2)23(18(25)11-16(19)22-24)12-15-8-5-6-10-21-15/h3-11,22H,12H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
173n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330733
PNG
(2-(2-chloro-4-fluorophenyl)-4-methyl-5-(pyridin-2-...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C19H14ClFN4O2/c1-11-18-15(9-17(26)24(11)10-13-4-2-3-7-22-13)23-25(19(18)27)16-6-5-12(21)8-14(16)20/h2-9,23H,10H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
235n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330723
PNG
(2-(2-chlorophenyl)-4-methyl-5-((6-morpholinopyridi...)
Show SMILES Cc1n(Cc2cccc(n2)N2CCOCC2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C23H22ClN5O3/c1-15-22-18(26-29(23(22)31)19-7-3-2-6-17(19)24)13-21(30)28(15)14-16-5-4-8-20(25-16)27-9-11-32-12-10-27/h2-8,13,26H,9-12,14H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
236n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330735
PNG
(2-(7-chloroquinolin-4-yl)-4-methyl-5-(pyridin-2-yl...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccnc4cc(Cl)ccc34)c(=O)c12
Show InChI InChI=1S/C22H16ClN5O2/c1-13-21-18(11-20(29)27(13)12-15-4-2-3-8-24-15)26-28(22(21)30)19-7-9-25-17-10-14(23)5-6-16(17)19/h2-11,26H,12H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
458n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330720
PNG
(2-(2-chlorophenyl)-4-methyl-5-(4-((4-methylpiperaz...)
Show SMILES CN1CCN(Cc2ccc(Cn3c(C)c4c(cc3=O)[nH]n(-c3ccccc3Cl)c4=O)cc2)CC1
Show InChI InChI=1S/C26H28ClN5O2/c1-18-25-22(28-32(26(25)34)23-6-4-3-5-21(23)27)15-24(33)31(18)17-20-9-7-19(8-10-20)16-30-13-11-29(2)12-14-30/h3-10,15,28H,11-14,16-17H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
515n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair