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3 similar compounds to monomer 50330729

Compile data set for download or QSAR
Wt: 346.3
BDBM50330730
Wt: 398.8
BDBM50330731
Wt: 380.8
BDBM50330732

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330730,50330731,50330732   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330732
PNG
(2-(4-chlorobenzyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3ccc(Cl)cc3)c(=O)c12
Show InChI InChI=1S/C20H17ClN4O2/c1-13-19-17(10-18(26)24(13)12-16-4-2-3-9-22-16)23-25(20(19)27)11-14-5-7-15(21)8-6-14/h2-10,23H,11-12H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
259n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330731
PNG
(2-(2-chloro-4-fluorobenzyl)-4-methyl-5-(pyridin-2-...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C20H16ClFN4O2/c1-12-19-17(9-18(27)25(12)11-15-4-2-3-7-23-15)24-26(20(19)28)10-13-5-6-14(22)8-16(13)21/h2-9,24H,10-11H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
342n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))
BDBM50330730
PNG
(2-benzyl-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazo...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C20H18N4O2/c1-14-19-17(11-18(25)23(14)13-16-9-5-6-10-21-16)22-24(20(19)26)12-15-7-3-2-4-8-15/h2-11,22H,12-13H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
463n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair