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8 similar compounds to monomer 50333184

Compile data set for download or QSAR
Wt: 298.3
BDBM50336811
Wt: 312.4
BDBM50336812
Wt: 326.4
BDBM50336813
Wt: 340.4
BDBM50336814
Wt: 354.4
BDBM50336815
Wt: 354.4
BDBM50336816
Wt: 368.5
BDBM50336817
Wt: 402.5
BDBM50336818

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50336811,50336812,50336813,50336814,50336815,50336816,50336817,50336818   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336811
PNG
(5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-prop...)
Show SMILES CCCc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C18H22N2O2/c1-4-5-15-14(10-19)17(13-8-6-11(2)7-9-13)16(18(21)22)12(3)20-15/h6-9H,4-5,10,19H2,1-3H3,(H,21,22)
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n/an/a 57n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336818
PNG
(5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O
Show InChI InChI=1S/C26H30N2O2/c1-17-10-12-19(13-11-17)23-20(16-27)22(15-26(2,3)4)28-21(24(23)25(29)30)14-18-8-6-5-7-9-18/h5-13H,14-16,27H2,1-4H3,(H,29,30)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336813
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(C)c1C(O)=O
Show InChI InChI=1S/C20H26N2O2/c1-12-6-8-14(9-7-12)18-15(11-21)16(10-20(3,4)5)22-13(2)17(18)19(23)24/h6-9H,10-11,21H2,1-5H3,(H,23,24)
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n/an/a 18n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336814
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C21H28N2O2/c1-6-16-19(20(24)25)18(14-9-7-13(2)8-10-14)15(12-22)17(23-16)11-21(3,4)5/h7-10H,6,11-12,22H2,1-5H3,(H,24,25)
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n/an/a 5.70n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336815
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-7-17-20(21(25)26)19(15-10-8-14(2)9-11-15)16(13-23)18(24-17)12-22(3,4)5/h8-11H,6-7,12-13,23H2,1-5H3,(H,25,26)
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n/an/a 4.40n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336816
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methyl...)
Show SMILES CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-13(2)20-19(21(25)26)18(15-9-7-14(3)8-10-15)16(12-23)17(24-20)11-22(4,5)6/h7-10,13H,11-12,23H2,1-6H3,(H,25,26)
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n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336817
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CC(C)Cc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C23H32N2O2/c1-14(2)11-18-21(22(26)27)20(16-9-7-15(3)8-10-16)17(13-24)19(25-18)12-23(4,5)6/h7-10,14H,11-13,24H2,1-6H3,(H,26,27)
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n/an/a 4.60n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336818
PNG
(5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O
Show InChI InChI=1S/C26H30N2O2/c1-17-10-12-19(13-11-17)23-20(16-27)22(15-26(2,3)4)28-21(24(23)25(29)30)14-18-8-6-5-7-9-18/h5-13H,14-16,27H2,1-4H3,(H,29,30)
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336812
PNG
(5-(Aminomethyl)-6-butyl-2-methyl-4-(4-methylphenyl...)
Show SMILES CCCCc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C19H24N2O2/c1-4-5-6-16-15(11-20)18(14-9-7-12(2)8-10-14)17(19(22)23)13(3)21-16/h7-10H,4-6,11,20H2,1-3H3,(H,22,23)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336813
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(C)c1C(O)=O
Show InChI InChI=1S/C20H26N2O2/c1-12-6-8-14(9-7-12)18-15(11-21)16(10-20(3,4)5)22-13(2)17(18)19(23)24/h6-9H,10-11,21H2,1-5H3,(H,23,24)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336814
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C21H28N2O2/c1-6-16-19(20(24)25)18(14-9-7-13(2)8-10-14)15(12-22)17(23-16)11-21(3,4)5/h7-10H,6,11-12,22H2,1-5H3,(H,24,25)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336815
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-7-17-20(21(25)26)19(15-10-8-14(2)9-11-15)16(13-23)18(24-17)12-22(3,4)5/h8-11H,6-7,12-13,23H2,1-5H3,(H,25,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336816
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methyl...)
Show SMILES CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-13(2)20-19(21(25)26)18(15-9-7-14(3)8-10-15)16(12-23)17(24-20)11-22(4,5)6/h7-10,13H,11-12,23H2,1-6H3,(H,25,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336817
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CC(C)Cc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C23H32N2O2/c1-14(2)11-18-21(22(26)27)20(16-9-7-15(3)8-10-16)17(13-24)19(25-18)12-23(4,5)6/h7-10,14H,11-13,24H2,1-6H3,(H,26,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336818
PNG
(5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O
Show InChI InChI=1S/C26H30N2O2/c1-17-10-12-19(13-11-17)23-20(16-27)22(15-26(2,3)4)28-21(24(23)25(29)30)14-18-8-6-5-7-9-18/h5-13H,14-16,27H2,1-4H3,(H,29,30)
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n/an/a 250n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336813
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(C)c1C(O)=O
Show InChI InChI=1S/C20H26N2O2/c1-12-6-8-14(9-7-12)18-15(11-21)16(10-20(3,4)5)22-13(2)17(18)19(23)24/h6-9H,10-11,21H2,1-5H3,(H,23,24)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336814
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C21H28N2O2/c1-6-16-19(20(24)25)18(14-9-7-13(2)8-10-14)15(12-22)17(23-16)11-21(3,4)5/h7-10H,6,11-12,22H2,1-5H3,(H,24,25)
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n/an/a 820n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336815
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-7-17-20(21(25)26)19(15-10-8-14(2)9-11-15)16(13-23)18(24-17)12-22(3,4)5/h8-11H,6-7,12-13,23H2,1-5H3,(H,25,26)
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n/an/a 630n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336816
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methyl...)
Show SMILES CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-13(2)20-19(21(25)26)18(15-9-7-14(3)8-10-15)16(12-23)17(24-20)11-22(4,5)6/h7-10,13H,11-12,23H2,1-6H3,(H,25,26)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336817
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CC(C)Cc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C23H32N2O2/c1-14(2)11-18-21(22(26)27)20(16-9-7-15(3)8-10-16)17(13-24)19(25-18)12-23(4,5)6/h7-10,14H,11-13,24H2,1-6H3,(H,26,27)
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n/an/a 420n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50336818
PNG
(5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O
Show InChI InChI=1S/C26H30N2O2/c1-17-10-12-19(13-11-17)23-20(16-27)22(15-26(2,3)4)28-21(24(23)25(29)30)14-18-8-6-5-7-9-18/h5-13H,14-16,27H2,1-4H3,(H,29,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP8 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336813
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(C)c1C(O)=O
Show InChI InChI=1S/C20H26N2O2/c1-12-6-8-14(9-7-12)18-15(11-21)16(10-20(3,4)5)22-13(2)17(18)19(23)24/h6-9H,10-11,21H2,1-5H3,(H,23,24)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336814
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C21H28N2O2/c1-6-16-19(20(24)25)18(14-9-7-13(2)8-10-14)15(12-22)17(23-16)11-21(3,4)5/h7-10H,6,11-12,22H2,1-5H3,(H,24,25)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336815
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-7-17-20(21(25)26)19(15-10-8-14(2)9-11-15)16(13-23)18(24-17)12-22(3,4)5/h8-11H,6-7,12-13,23H2,1-5H3,(H,25,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336816
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methyl...)
Show SMILES CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-13(2)20-19(21(25)26)18(15-9-7-14(3)8-10-15)16(12-23)17(24-20)11-22(4,5)6/h7-10,13H,11-12,23H2,1-6H3,(H,25,26)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50336817
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CC(C)Cc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C23H32N2O2/c1-14(2)11-18-21(22(26)27)20(16-9-7-15(3)8-10-16)17(13-24)19(25-18)12-23(4,5)6/h7-10,14H,11-13,24H2,1-6H3,(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human DPP9 expressed in human 293F cells after 90 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50336812
PNG
(5-(Aminomethyl)-6-butyl-2-methyl-4-(4-methylphenyl...)
Show SMILES CCCCc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C19H24N2O2/c1-4-5-6-16-15(11-20)18(14-9-7-12(2)8-10-14)17(19(22)23)13(3)21-16/h7-10H,4-6,11,20H2,1-3H3,(H,22,23)
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n/an/a 58n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP4 in human Caco2 cells after 60 mins


J Med Chem 54: 831-50 (2012)


Article DOI: 10.1021/jm101236h
BindingDB Entry DOI: 10.7270/Q2QR4Z4M
More data for this
Ligand-Target Pair