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8 similar compounds to monomer 50347394

Compile data set for download or QSAR
Wt: 437.4
BDBM50347393
Wt: 502.0
BDBM50347395
Wt: 515.9
BDBM50347399
Wt: 467.5
BDBM50347401
Wt: 495.5
BDBM50347405
Wt: 481.5
BDBM50347415
Wt: 451.5
BDBM50347424
Wt: 516.0
BDBM50347426

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50347393,50347395,50347399,50347401,50347405,50347415,50347424,50347426   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347393
PNG
(CHEMBL1801565)
Show SMILES Cn1cnc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NCc3cccnc3)cc2c1=O
Show InChI InChI=1S/C26H23N5O2/c1-3-13-31(17-19-6-11-24-23(14-19)26(33)30(2)18-29-24)22-9-7-21(8-10-22)25(32)28-16-20-5-4-12-27-15-20/h1,4-12,14-15,18H,13,16-17H2,2H3,(H,28,32)
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n/an/a 12n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347395
PNG
(CHEMBL1801567)
Show SMILES CC(C)=CCN(Cc1cc2c(cc1Cl)ncn(C)c2=O)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C28H28ClN5O2/c1-19(2)10-12-34(17-22-13-24-26(14-25(22)29)32-18-33(3)28(24)36)23-8-6-21(7-9-23)27(35)31-16-20-5-4-11-30-15-20/h4-11,13-15,18H,12,16-17H2,1-3H3,(H,31,35)
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n/an/a 2.60n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347399
PNG
(CHEMBL1801571)
Show SMILES CC(C)=CC(=O)N(Cc1cc2c(cc1Cl)ncn(C)c2=O)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C28H26ClN5O3/c1-18(2)11-26(35)34(16-21-12-23-25(13-24(21)29)32-17-33(3)28(23)37)22-8-6-20(7-9-22)27(36)31-15-19-5-4-10-30-14-19/h4-14,17H,15-16H2,1-3H3,(H,31,36)
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n/an/a 660n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347426
PNG
(CHEMBL1801935)
Show SMILES CC(C)=CCN(Cc1cc2c(cc1Cl)nc(C)n(C)c2=O)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H30ClN5O2/c1-19(2)11-13-35(18-23-14-25-27(15-26(23)30)33-20(3)34(4)29(25)37)24-9-7-22(8-10-24)28(36)32-17-21-6-5-12-31-16-21/h5-12,14-16H,13,17-18H2,1-4H3,(H,32,36)
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n/an/a 11n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347405
PNG
(CHEMBL1801859)
Show SMILES CC(C)=CC(=O)N(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H29N5O3/c1-19(2)14-27(35)34(18-21-7-12-26-25(15-21)29(37)33(4)20(3)32-26)24-10-8-23(9-11-24)28(36)31-17-22-6-5-13-30-16-22/h5-16H,17-18H2,1-4H3,(H,31,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347415
PNG
(CHEMBL1801552)
Show SMILES CC(C)=CCN(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C29H31N5O2/c1-20(2)13-15-34(19-22-7-12-27-26(16-22)29(36)33(4)21(3)32-27)25-10-8-24(9-11-25)28(35)31-18-23-6-5-14-30-17-23/h5-14,16-17H,15,18-19H2,1-4H3,(H,31,35)
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n/an/a 1.40n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347424
PNG
(CHEMBL1801937)
Show SMILES Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NCc3cccnc3)cc2c(=O)n1C
Show InChI InChI=1S/C27H25N5O2/c1-4-14-32(18-20-7-12-25-24(15-20)27(34)31(3)19(2)30-25)23-10-8-22(9-11-23)26(33)29-17-21-6-5-13-28-16-21/h1,5-13,15-16H,14,17-18H2,2-3H3,(H,29,33)
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n/an/a 3.60n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50347401
PNG
(CHEMBL1801855)
Show SMILES C\C=C\CN(Cc1ccc2nc(C)n(C)c(=O)c2c1)c1ccc(cc1)C(=O)NCc1cccnc1
Show InChI InChI=1S/C28H29N5O2/c1-4-5-15-33(19-21-8-13-26-25(16-21)28(35)32(3)20(2)31-26)24-11-9-23(10-12-24)27(34)30-18-22-7-6-14-29-17-22/h4-14,16-17H,15,18-19H2,1-3H3,(H,30,34)/b5-4+
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n/an/a 2.90n/an/an/an/an/an/a



Myrexis, Inc.

Curated by ChEMBL


Assay Description
Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide


J Med Chem 53: 8734-46 (2010)


Article DOI: 10.1021/jm101145b
BindingDB Entry DOI: 10.7270/Q26H4HSP
More data for this
Ligand-Target Pair