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13 similar compounds to monomer 50351324

Compile data set for download or QSAR
Wt: 416.9
BDBM50351308
Wt: 444.9
BDBM50351310
Wt: 507.0
BDBM50351311
Wt: 442.9
BDBM50351312
Wt: 457.0
BDBM50351313
Wt: 472.0
BDBM50351314
Wt: 402.9
BDBM50351315
Wt: 444.9
BDBM50351317
Wt: 458.9
BDBM50351318
Wt: 408.5
BDBM50351321
Wt: 422.5
BDBM50351322
Wt: 438.5
BDBM50351323
Wt: 458.9
BDBM50351327

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50351308,50351310,50351311,50351312,50351313,50351314,50351315,50351317,50351318,50351321,50351322,50351323,50351327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351308
PNG
(CHEMBL1818795)
Show SMILES CN(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C26H25ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-16H,3-4,17H2,1-2H3,(H,28,30)
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n/an/a 1.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351312
PNG
(CHEMBL1818800)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32)
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n/an/a 4.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351311
PNG
(CHEMBL1818798)
Show SMILES CN(CCc1ccccc1)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C33H31ClN2O/c1-36(20-19-24-5-3-2-4-6-24)23-25-7-8-30-22-32(18-15-29(30)21-25)35-33(37)28-11-9-26(10-12-28)27-13-16-31(34)17-14-27/h2-6,9-18,21-22H,7-8,19-20,23H2,1H3,(H,35,37)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351312
PNG
(CHEMBL1818800)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351313
PNG
(CHEMBL1818801)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCCC3)CCc2c1
Show InChI InChI=1S/C29H29ClN2O/c30-27-13-10-23(11-14-27)22-6-8-24(9-7-22)29(33)31-28-15-12-25-18-21(4-5-26(25)19-28)20-32-16-2-1-3-17-32/h6-15,18-19H,1-5,16-17,20H2,(H,31,33)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351314
PNG
(CHEMBL1818802)
Show SMILES CN1CCN(CC2=Cc3ccc(NC(=O)c4ccc(cc4)-c4ccc(Cl)cc4)cc3CC2)CC1
Show InChI InChI=1S/C29H30ClN3O/c1-32-14-16-33(17-15-32)20-21-2-3-26-19-28(13-10-25(26)18-21)31-29(34)24-6-4-22(5-7-24)23-8-11-27(30)12-9-23/h4-13,18-19H,2-3,14-17,20H2,1H3,(H,31,34)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351315
PNG
(CHEMBL1818803)
Show SMILES CNCC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C25H23ClN2O/c1-27-16-17-2-3-22-15-24(13-10-21(22)14-17)28-25(29)20-6-4-18(5-7-20)19-8-11-23(26)12-9-19/h4-15,27H,2-3,16H2,1H3,(H,28,29)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351317
PNG
(CHEMBL1818805)
Show SMILES CN(CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1)C(C)=O
Show InChI InChI=1S/C27H25ClN2O2/c1-18(31)30(2)17-19-3-4-24-16-26(14-11-23(24)15-19)29-27(32)22-7-5-20(6-8-22)21-9-12-25(28)13-10-21/h5-16H,3-4,17H2,1-2H3,(H,29,32)
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n/an/a 6.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351318
PNG
(CHEMBL1818806)
Show SMILES CCC(=O)N(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C28H27ClN2O2/c1-3-27(32)31(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30-28(33)22-8-6-20(7-9-22)21-10-13-25(29)14-11-21/h6-17H,3-5,18H2,1-2H3,(H,30,33)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351321
PNG
(CHEMBL1818809)
Show SMILES O=C(Nc1ccc2C=C(CN3CCCC3)CCc2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O/c31-28(24-12-10-23(11-13-24)22-6-2-1-3-7-22)29-27-15-14-25-18-21(8-9-26(25)19-27)20-30-16-4-5-17-30/h1-3,6-7,10-15,18-19H,4-5,8-9,16-17,20H2,(H,29,31)
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n/an/a 6.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351322
PNG
(CHEMBL1818810)
Show SMILES Cc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C29H30N2O/c1-21-4-7-23(8-5-21)24-10-12-25(13-11-24)29(32)30-28-15-14-26-18-22(6-9-27(26)19-28)20-31-16-2-3-17-31/h4-5,7-8,10-15,18-19H,2-3,6,9,16-17,20H2,1H3,(H,30,32)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351323
PNG
(CHEMBL1818811)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C29H30N2O2/c1-33-28-14-11-23(12-15-28)22-6-8-24(9-7-22)29(32)30-27-13-10-25-18-21(4-5-26(25)19-27)20-31-16-2-3-17-31/h6-15,18-19H,2-5,16-17,20H2,1H3,(H,30,32)
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351308
PNG
(CHEMBL1818795)
Show SMILES CN(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C26H25ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-16H,3-4,17H2,1-2H3,(H,28,30)
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n/an/a 6.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351311
PNG
(CHEMBL1818798)
Show SMILES CN(CCc1ccccc1)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C33H31ClN2O/c1-36(20-19-24-5-3-2-4-6-24)23-25-7-8-30-22-32(18-15-29(30)21-25)35-33(37)28-11-9-26(10-12-28)27-13-16-31(34)17-14-27/h2-6,9-18,21-22H,7-8,19-20,23H2,1H3,(H,35,37)
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n/an/a 33n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351327
PNG
(CHEMBL1818799)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCOCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O2/c29-26-10-7-22(8-11-26)21-3-5-23(6-4-21)28(32)30-27-12-9-24-17-20(1-2-25(24)18-27)19-31-13-15-33-16-14-31/h3-12,17-18H,1-2,13-16,19H2,(H,30,32)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351313
PNG
(CHEMBL1818801)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCCC3)CCc2c1
Show InChI InChI=1S/C29H29ClN2O/c30-27-13-10-23(11-14-27)22-6-8-24(9-7-22)29(33)31-28-15-12-25-18-21(4-5-26(25)19-28)20-32-16-2-1-3-17-32/h6-15,18-19H,1-5,16-17,20H2,(H,31,33)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351321
PNG
(CHEMBL1818809)
Show SMILES O=C(Nc1ccc2C=C(CN3CCCC3)CCc2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O/c31-28(24-12-10-23(11-13-24)22-6-2-1-3-7-22)29-27-15-14-25-18-21(8-9-26(25)19-27)20-30-16-4-5-17-30/h1-3,6-7,10-15,18-19H,4-5,8-9,16-17,20H2,(H,29,31)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation coun...


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351308
PNG
(CHEMBL1818795)
Show SMILES CN(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C26H25ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-16H,3-4,17H2,1-2H3,(H,28,30)
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n/an/a 2.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351310
PNG
(CHEMBL1818797)
Show SMILES CCN(CC)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C28H29ClN2O/c1-3-31(4-2)19-20-5-6-25-18-27(16-13-24(25)17-20)30-28(32)23-9-7-21(8-10-23)22-11-14-26(29)15-12-22/h7-18H,3-6,19H2,1-2H3,(H,30,32)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351311
PNG
(CHEMBL1818798)
Show SMILES CN(CCc1ccccc1)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C33H31ClN2O/c1-36(20-19-24-5-3-2-4-6-24)23-25-7-8-30-22-32(18-15-29(30)21-25)35-33(37)28-11-9-26(10-12-28)27-13-16-31(34)17-14-27/h2-6,9-18,21-22H,7-8,19-20,23H2,1H3,(H,35,37)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351327
PNG
(CHEMBL1818799)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCOCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O2/c29-26-10-7-22(8-11-26)21-3-5-23(6-4-21)28(32)30-27-12-9-24-17-20(1-2-25(24)18-27)19-31-13-15-33-16-14-31/h3-12,17-18H,1-2,13-16,19H2,(H,30,32)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351312
PNG
(CHEMBL1818800)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32)
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351313
PNG
(CHEMBL1818801)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCCC3)CCc2c1
Show InChI InChI=1S/C29H29ClN2O/c30-27-13-10-23(11-14-27)22-6-8-24(9-7-22)29(33)31-28-15-12-25-18-21(4-5-26(25)19-28)20-32-16-2-1-3-17-32/h6-15,18-19H,1-5,16-17,20H2,(H,31,33)
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351314
PNG
(CHEMBL1818802)
Show SMILES CN1CCN(CC2=Cc3ccc(NC(=O)c4ccc(cc4)-c4ccc(Cl)cc4)cc3CC2)CC1
Show InChI InChI=1S/C29H30ClN3O/c1-32-14-16-33(17-15-32)20-21-2-3-26-19-28(13-10-25(26)18-21)31-29(34)24-6-4-22(5-7-24)23-8-11-27(30)12-9-23/h4-13,18-19H,2-3,14-17,20H2,1H3,(H,31,34)
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n/an/a 5.30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351315
PNG
(CHEMBL1818803)
Show SMILES CNCC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C25H23ClN2O/c1-27-16-17-2-3-22-15-24(13-10-21(22)14-17)28-25(29)20-6-4-18(5-7-20)19-8-11-23(26)12-9-19/h4-15,27H,2-3,16H2,1H3,(H,28,29)
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n/an/a 8.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351317
PNG
(CHEMBL1818805)
Show SMILES CN(CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1)C(C)=O
Show InChI InChI=1S/C27H25ClN2O2/c1-18(31)30(2)17-19-3-4-24-16-26(14-11-23(24)15-19)29-27(32)22-7-5-20(6-8-22)21-9-12-25(28)13-10-21/h5-16H,3-4,17H2,1-2H3,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351318
PNG
(CHEMBL1818806)
Show SMILES CCC(=O)N(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C28H27ClN2O2/c1-3-27(32)31(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30-28(33)22-8-6-20(7-9-22)21-10-13-25(29)14-11-21/h6-17H,3-5,18H2,1-2H3,(H,30,33)
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n/an/a 6.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351321
PNG
(CHEMBL1818809)
Show SMILES O=C(Nc1ccc2C=C(CN3CCCC3)CCc2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O/c31-28(24-12-10-23(11-13-24)22-6-2-1-3-7-22)29-27-15-14-25-18-21(8-9-26(25)19-27)20-30-16-4-5-17-30/h1-3,6-7,10-15,18-19H,4-5,8-9,16-17,20H2,(H,29,31)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351322
PNG
(CHEMBL1818810)
Show SMILES Cc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C29H30N2O/c1-21-4-7-23(8-5-21)24-10-12-25(13-11-24)29(32)30-28-15-14-26-18-22(6-9-27(26)19-28)20-31-16-2-3-17-31/h4-5,7-8,10-15,18-19H,2-3,6,9,16-17,20H2,1H3,(H,30,32)
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n/an/a 2.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50351323
PNG
(CHEMBL1818811)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1
Show InChI InChI=1S/C29H30N2O2/c1-33-28-14-11-23(12-15-28)22-6-8-24(9-7-22)29(32)30-27-13-10-25-18-21(4-5-26(25)19-27)20-31-16-2-3-17-31/h6-15,18-19H,2-5,16-17,20H2,1H3,(H,30,32)
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n/an/a 3.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351327
PNG
(CHEMBL1818799)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCOCC3)CCc2c1
Show InChI InChI=1S/C28H27ClN2O2/c29-26-10-7-22(8-11-26)21-3-5-23(6-4-21)28(32)30-27-12-9-24-17-20(1-2-25(24)18-27)19-31-13-15-33-16-14-31/h3-12,17-18H,1-2,13-16,19H2,(H,30,32)
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n/an/a 8.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50351310
PNG
(CHEMBL1818797)
Show SMILES CCN(CC)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1
Show InChI InChI=1S/C28H29ClN2O/c1-3-31(4-2)19-20-5-6-25-18-27(16-13-24(25)17-20)30-28(32)23-9-7-21(8-10-23)22-11-14-26(29)15-12-22/h7-18H,3-6,19H2,1-2H3,(H,30,32)
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n/an/a 9.90n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting


Bioorg Med Chem 19: 5539-52 (2011)


Article DOI: 10.1016/j.bmc.2011.07.038
BindingDB Entry DOI: 10.7270/Q26H4HT4
More data for this
Ligand-Target Pair