BindingDB logo
myBDB logout

2 similar compounds to monomer 50133938

Compile data set for download or QSAR
Wt: 424.5
BDBM50351459
Wt: 438.6
BDBM50351460

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351459,50351460   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated T-type calcium channel


(Homo sapiens (Human))
BDBM50351460
PNG
(CHEMBL1819513)
Show SMILES CCC(CC)(CNC(=O)C1CCN(CCCCc2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H39FN2O/c1-3-28(4-2,25-13-15-26(29)16-14-25)22-30-27(32)24-17-20-31(21-18-24)19-9-8-12-23-10-6-5-7-11-23/h5-7,10-11,13-16,24H,3-4,8-9,12,17-22H2,1-2H3,(H,30,32)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay


Bioorg Med Chem 19: 5628-38 (2011)


Article DOI: 10.1016/j.bmc.2011.07.030
BindingDB Entry DOI: 10.7270/Q29887DG
More data for this
Ligand-Target Pair
Voltage-gated T-type calcium channel


(Homo sapiens (Human))
BDBM50351459
PNG
(CHEMBL1819512)
Show SMILES CCC(CC)(CNC(=O)C1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H37FN2O/c1-3-27(4-2,24-12-14-25(28)15-13-24)21-29-26(31)23-16-19-30(20-17-23)18-8-11-22-9-6-5-7-10-22/h5-7,9-10,12-15,23H,3-4,8,11,16-21H2,1-2H3,(H,29,31)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay


Bioorg Med Chem 19: 5628-38 (2011)


Article DOI: 10.1016/j.bmc.2011.07.030
BindingDB Entry DOI: 10.7270/Q29887DG
More data for this
Ligand-Target Pair