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16 molecules are shown

Compile data set for download or QSAR
Wt: 415.9
BDBM50354037
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50354037   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354037
PNG
(CHEMBL1828891)
Show SMILES CCCN(CCC)c1c(CCC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C22H30ClN5O/c1-5-8-17-21(25-19-10-9-16(29-4)15-18(19)23)26-20-11-12-24-28(20)22(17)27(13-6-2)14-7-3/h9-12,15H,5-8,13-14H2,1-4H3,(H,25,26)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354037
PNG
(CHEMBL1828891)
Show SMILES CCCN(CCC)c1c(CCC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C22H30ClN5O/c1-5-8-17-21(25-19-10-9-16(29-4)15-18(19)23)26-20-11-12-24-28(20)22(17)27(13-6-2)14-7-3/h9-12,15H,5-8,13-14H2,1-4H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 95n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair