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10 molecules are shown

Wt: 319.2
BDBM50355636
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Wt: 284.7
BDBM50355640
Purchase
Wt: 392.0
BDBM50355644
Wt: 381.2
BDBM50355650
Wt: 313.1
BDBM50355652
Wt: 284.7
BDBM50355653
Wt: 390.3
BDBM50355654
Wt: 447.7
BDBM50355633
Wt: 428.3
BDBM50355634
Wt: 485.3
BDBM50355641

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50355636,50355640,50355644,50355650,50355652,50355653,50355654,50355633,50355634,50355641   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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2.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355633
PNG
(CHEMBL1910969)
Show SMILES OC(=O)c1ccc(cc1SCc1ccc(Cl)c(Cl)c1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C22H13Cl3O2S/c23-17-3-1-2-14(10-17)4-5-15-6-8-18(22(26)27)21(12-15)28-13-16-7-9-19(24)20(25)11-16/h1-3,6-12H,13H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355640
PNG
(CHEMBL1910877)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-8(2-4-9)7-17-10-5-6-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355641
PNG
(CHEMBL1910968)
Show SMILES NCC(=O)Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H18Cl2N2O3S/c25-20-9-7-17(11-21(20)26)14-32-22-12-16(6-8-19(22)24(30)31)5-4-15-2-1-3-18(10-15)28-23(29)13-27/h1-3,6-12H,13-14,27H2,(H,28,29)(H,30,31)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355644
PNG
(CHEMBL1910965)
Show SMILES OC(=O)c1ccc(Br)cc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H9BrCl2O2S/c15-9-2-3-10(14(18)19)13(6-9)20-7-8-1-4-11(16)12(17)5-8/h1-6H,7H2,(H,18,19)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355640
PNG
(CHEMBL1910877)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-8(2-4-9)7-17-10-5-6-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355650
PNG
(CHEMBL1910966)
Show SMILES OCCC#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C18H14Cl2O3S/c19-15-7-5-13(9-16(15)20)11-24-17-10-12(3-1-2-8-21)4-6-14(17)18(22)23/h4-7,9-10,21H,2,8,11H2,(H,22,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355652
PNG
(CHEMBL1910963)
Show SMILES OC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2O2S/c15-11-6-5-9(7-12(11)16)8-19-13-4-2-1-3-10(13)14(17)18/h1-7H,8H2,(H,17,18)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355653
PNG
(CHEMBL1910878)
Show SMILES OC(=O)c1sccc1SCc1cccc(Cl)c1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-2-8(6-9)7-17-10-4-5-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355652
PNG
(CHEMBL1910963)
Show SMILES OC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2O2S/c15-11-6-5-9(7-12(11)16)8-19-13-4-2-1-3-10(13)14(17)18/h1-7H,8H2,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355653
PNG
(CHEMBL1910878)
Show SMILES OC(=O)c1sccc1SCc1cccc(Cl)c1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-2-8(6-9)7-17-10-4-5-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355650
PNG
(CHEMBL1910966)
Show SMILES OCCC#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C18H14Cl2O3S/c19-15-7-5-13(9-16(15)20)11-24-17-10-12(3-1-2-8-21)4-6-14(17)18(22)23/h4-7,9-10,21H,2,8,11H2,(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 7.90E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355650
PNG
(CHEMBL1910966)
Show SMILES OCCC#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C18H14Cl2O3S/c19-15-7-5-13(9-16(15)20)11-24-17-10-12(3-1-2-8-21)4-6-14(17)18(22)23/h4-7,9-10,21H,2,8,11H2,(H,22,23)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355652
PNG
(CHEMBL1910963)
Show SMILES OC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2O2S/c15-11-6-5-9(7-12(11)16)8-19-13-4-2-1-3-10(13)14(17)18/h1-7H,8H2,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355634
PNG
(CHEMBL1910967)
Show SMILES Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H15Cl2NO2S/c23-19-9-7-16(11-20(19)24)13-28-21-12-15(6-8-18(21)22(26)27)5-4-14-2-1-3-17(25)10-14/h1-3,6-12H,13,25H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355653
PNG
(CHEMBL1910878)
Show SMILES OC(=O)c1sccc1SCc1cccc(Cl)c1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-2-8(6-9)7-17-10-4-5-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a 9.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355641
PNG
(CHEMBL1910968)
Show SMILES NCC(=O)Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H18Cl2N2O3S/c25-20-9-7-17(11-21(20)26)14-32-22-12-16(6-8-19(22)24(30)31)5-4-15-2-1-3-18(10-15)28-23(29)13-27/h1-3,6-12H,13-14,27H2,(H,28,29)(H,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355634
PNG
(CHEMBL1910967)
Show SMILES Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H15Cl2NO2S/c23-19-9-7-16(11-20(19)24)13-28-21-12-15(6-8-18(21)22(26)27)5-4-14-2-1-3-17(25)10-14/h1-3,6-12H,13,25H2,(H,26,27)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355644
PNG
(CHEMBL1910965)
Show SMILES OC(=O)c1ccc(Br)cc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H9BrCl2O2S/c15-9-2-3-10(14(18)19)13(6-9)20-7-8-1-4-11(16)12(17)5-8/h1-6H,7H2,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a 7.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355641
PNG
(CHEMBL1910968)
Show SMILES NCC(=O)Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H18Cl2N2O3S/c25-20-9-7-17(11-21(20)26)14-32-22-12-16(6-8-19(22)24(30)31)5-4-15-2-1-3-18(10-15)28-23(29)13-27/h1-3,6-12H,13-14,27H2,(H,28,29)(H,30,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355640
PNG
(CHEMBL1910877)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-8(2-4-9)7-17-10-5-6-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355644
PNG
(CHEMBL1910965)
Show SMILES OC(=O)c1ccc(Br)cc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H9BrCl2O2S/c15-9-2-3-10(14(18)19)13(6-9)20-7-8-1-4-11(16)12(17)5-8/h1-6H,7H2,(H,18,19)
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n/an/a 3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355633
PNG
(CHEMBL1910969)
Show SMILES OC(=O)c1ccc(cc1SCc1ccc(Cl)c(Cl)c1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C22H13Cl3O2S/c23-17-3-1-2-14(10-17)4-5-15-6-8-18(22(26)27)21(12-15)28-13-16-7-9-19(24)20(25)11-16/h1-3,6-12H,13H2,(H,26,27)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355633
PNG
(CHEMBL1910969)
Show SMILES OC(=O)c1ccc(cc1SCc1ccc(Cl)c(Cl)c1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C22H13Cl3O2S/c23-17-3-1-2-14(10-17)4-5-15-6-8-18(22(26)27)21(12-15)28-13-16-7-9-19(24)20(25)11-16/h1-3,6-12H,13H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355634
PNG
(CHEMBL1910967)
Show SMILES Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H15Cl2NO2S/c23-19-9-7-16(11-20(19)24)13-28-21-12-15(6-8-18(21)22(26)27)5-4-14-2-1-3-17(25)10-14/h1-3,6-12H,13,25H2,(H,26,27)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair