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8 molecules are shown

Wt: 319.2
BDBM50355636
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Wt: 351.2
BDBM50355637
Wt: 532.4
BDBM50355649
Wt: 390.3
BDBM50355654
Wt: 458.4
BDBM50355638
Wt: 473.4
BDBM50355642
Wt: 396.3
BDBM50355643
Wt: 546.4
BDBM50355646

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50355636,50355637,50355649,50355654,50355638,50355642,50355643,50355646   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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PubMed
2.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355637
PNG
(CHEMBL1910885)
Show SMILES OC(=O)c1sccc1S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O4S2/c13-8-2-1-7(5-9(8)14)6-20(17,18)10-3-4-19-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355638
PNG
(CHEMBL1910887)
Show SMILES Clc1ccc(CSc2ccsc2C(=O)NS(=O)(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C18H13Cl2NO3S3/c19-14-7-6-12(10-15(14)20)11-26-16-8-9-25-17(16)18(22)21-27(23,24)13-4-2-1-3-5-13/h1-10H,11H2,(H,21,22)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355642
PNG
(CHEMBL1910888)
Show SMILES Nc1cccc(c1)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14Cl2N2O3S3/c19-14-5-4-11(8-15(14)20)10-27-16-6-7-26-17(16)18(23)22-28(24,25)13-3-1-2-12(21)9-13/h1-9H,10,21H2,(H,22,23)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355643
PNG
(CHEMBL1910886)
Show SMILES CS(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H11Cl2NO3S3/c1-22(18,19)16-13(17)12-11(4-5-20-12)21-7-8-2-3-9(14)10(15)6-8/h2-6H,7H2,1H3,(H,16,17)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355646
PNG
(CHEMBL1910962)
Show SMILES COC(=O)c1cc(ccc1OC)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H17Cl2NO6S3/c1-29-17-6-4-13(10-14(17)21(26)30-2)33(27,28)24-20(25)19-18(7-8-31-19)32-11-12-3-5-15(22)16(23)9-12/h3-10H,11H2,1-2H3,(H,24,25)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355638
PNG
(CHEMBL1910887)
Show SMILES Clc1ccc(CSc2ccsc2C(=O)NS(=O)(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C18H13Cl2NO3S3/c19-14-7-6-12(10-15(14)20)11-26-16-8-9-25-17(16)18(22)21-27(23,24)13-4-2-1-3-5-13/h1-10H,11H2,(H,21,22)
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n/an/a 4.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355642
PNG
(CHEMBL1910888)
Show SMILES Nc1cccc(c1)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14Cl2N2O3S3/c19-14-5-4-11(8-15(14)20)10-27-16-6-7-26-17(16)18(23)22-28(24,25)13-3-1-2-12(21)9-13/h1-9H,10,21H2,(H,22,23)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355649
PNG
(CHEMBL1910889)
Show SMILES COc1ccc(cc1C(O)=O)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H15Cl2NO6S3/c1-29-16-5-3-12(9-13(16)20(25)26)32(27,28)23-19(24)18-17(6-7-30-18)31-10-11-2-4-14(21)15(22)8-11/h2-9H,10H2,1H3,(H,23,24)(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355643
PNG
(CHEMBL1910886)
Show SMILES CS(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H11Cl2NO3S3/c1-22(18,19)16-13(17)12-11(4-5-20-12)21-7-8-2-3-9(14)10(15)6-8/h2-6H,7H2,1H3,(H,16,17)
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n/an/a 7.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 7.90E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355646
PNG
(CHEMBL1910962)
Show SMILES COC(=O)c1cc(ccc1OC)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H17Cl2NO6S3/c1-29-17-6-4-13(10-14(17)21(26)30-2)33(27,28)24-20(25)19-18(7-8-31-19)32-11-12-3-5-15(22)16(23)9-12/h3-10H,11H2,1-2H3,(H,24,25)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355637
PNG
(CHEMBL1910885)
Show SMILES OC(=O)c1sccc1S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O4S2/c13-8-2-1-7(5-9(8)14)6-20(17,18)10-3-4-19-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355643
PNG
(CHEMBL1910886)
Show SMILES CS(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H11Cl2NO3S3/c1-22(18,19)16-13(17)12-11(4-5-20-12)21-7-8-2-3-9(14)10(15)6-8/h2-6H,7H2,1H3,(H,16,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355642
PNG
(CHEMBL1910888)
Show SMILES Nc1cccc(c1)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14Cl2N2O3S3/c19-14-5-4-11(8-15(14)20)10-27-16-6-7-26-17(16)18(23)22-28(24,25)13-3-1-2-12(21)9-13/h1-9H,10,21H2,(H,22,23)
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n/an/a 8.10E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355649
PNG
(CHEMBL1910889)
Show SMILES COc1ccc(cc1C(O)=O)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H15Cl2NO6S3/c1-29-16-5-3-12(9-13(16)20(25)26)32(27,28)23-19(24)18-17(6-7-30-18)31-10-11-2-4-14(21)15(22)8-11/h2-9H,10H2,1H3,(H,23,24)(H,25,26)
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355646
PNG
(CHEMBL1910962)
Show SMILES COC(=O)c1cc(ccc1OC)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H17Cl2NO6S3/c1-29-17-6-4-13(10-14(17)21(26)30-2)33(27,28)24-20(25)19-18(7-8-31-19)32-11-12-3-5-15(22)16(23)9-12/h3-10H,11H2,1-2H3,(H,24,25)
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n/an/a 7.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355638
PNG
(CHEMBL1910887)
Show SMILES Clc1ccc(CSc2ccsc2C(=O)NS(=O)(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C18H13Cl2NO3S3/c19-14-7-6-12(10-15(14)20)11-26-16-8-9-25-17(16)18(22)21-27(23,24)13-4-2-1-3-5-13/h1-10H,11H2,(H,21,22)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a 7.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50355649
PNG
(CHEMBL1910889)
Show SMILES COc1ccc(cc1C(O)=O)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H15Cl2NO6S3/c1-29-16-5-3-12(9-13(16)20(25)26)32(27,28)23-19(24)18-17(6-7-30-18)31-10-11-2-4-14(21)15(22)8-11/h2-9H,10H2,1H3,(H,23,24)(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated ...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma (PTPγ)


(Homo sapiens (Human))
BDBM50355637
PNG
(CHEMBL1910885)
Show SMILES OC(=O)c1sccc1S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O4S2/c13-8-2-1-7(5-9(8)14)6-20(17,18)10-3-4-19-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


J Med Chem 54: 6548-62 (2011)


Article DOI: 10.1021/jm2003766
BindingDB Entry DOI: 10.7270/Q2862GTG
More data for this
Ligand-Target Pair