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19 similar compounds to monomer 50359359

Wt: 464.5
BDBM50359336
Wt: 448.9
BDBM50359337
Wt: 434.9
BDBM50359343
Wt: 489.5
BDBM50359344
Wt: 448.9
BDBM50359345
Wt: 483.4
BDBM50359346
Wt: 483.4
BDBM50359347
Wt: 428.5
BDBM50359349
Wt: 473.9
BDBM50359350
Wt: 501.4
BDBM50359351
Wt: 585.5
BDBM50359352
Wt: 541.4
BDBM50359353
Wt: 540.4
BDBM50359354
Wt: 597.5
BDBM50359355
Wt: 554.4
BDBM50359356
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50359336,50359337,50359343,50359344,50359345,50359346,50359347,50359349,50359350,50359351,50359352,50359353,50359354,50359355,50359356   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Homo sapiens (human))
BDBM50359336
PNG
(CHEMBL1929216)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc3ccccc3c2)s1
Show InChI InChI=1S/C25H28N4O3S/c1-25(2,3)20-15-19(23(31)29-12-10-21(30)26-11-13-29)22(33-20)28-24(32)27-18-9-8-16-6-4-5-7-17(16)14-18/h4-9,14-15H,10-13H2,1-3H3,(H,26,30)(H2,27,28,32)
PDB
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n/an/a 12n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359356
PNG
(CHEMBL1929235)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCN(CCC(N)=O)C(=O)CC2)c(NC(=O)Nc2cccc(Cl)c2Cl)s1
Show InChI InChI=1S/C24H29Cl2N5O4S/c1-24(2,3)17-13-14(21(36-17)29-23(35)28-16-6-4-5-15(25)20(16)26)22(34)31-10-8-19(33)30(11-12-31)9-7-18(27)32/h4-6,13H,7-12H2,1-3H3,(H2,27,32)(H2,28,29,35)
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n/an/a 19n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359343
PNG
(CHEMBL1929223)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)C2)c(NC(=O)Nc2ccc(Cl)cc2)s1
Show InChI InChI=1S/C20H23ClN4O3S/c1-20(2,3)15-10-14(18(27)25-9-8-22-16(26)11-25)17(29-15)24-19(28)23-13-6-4-12(21)5-7-13/h4-7,10H,8-9,11H2,1-3H3,(H,22,26)(H2,23,24,28)
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n/an/a 86n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359344
PNG
(CHEMBL1929224)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(C#N)c3ccccc23)s1
Show InChI InChI=1S/C26H27N5O3S/c1-26(2,3)21-14-19(24(33)31-12-10-22(32)28-11-13-31)23(35-21)30-25(34)29-20-9-8-16(15-27)17-6-4-5-7-18(17)20/h4-9,14H,10-13H2,1-3H3,(H,28,32)(H2,29,30,34)
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n/an/a 6n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359345
PNG
(CHEMBL1929225)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2cccc(Cl)c2)s1
Show InChI InChI=1S/C21H25ClN4O3S/c1-21(2,3)16-12-15(19(28)26-9-7-17(27)23-8-10-26)18(30-16)25-20(29)24-14-6-4-5-13(22)11-14/h4-6,11-12H,7-10H2,1-3H3,(H,23,27)(H2,24,25,29)
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n/an/a 42n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359346
PNG
(CHEMBL1926710)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2cccc(Cl)c2Cl)s1
Show InChI InChI=1S/C21H24Cl2N4O3S/c1-21(2,3)15-11-12(19(29)27-9-7-16(28)24-8-10-27)18(31-15)26-20(30)25-14-6-4-5-13(22)17(14)23/h4-6,11H,7-10H2,1-3H3,(H,24,28)(H2,25,26,30)
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n/an/a 10n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359347
PNG
(CHEMBL1929226)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(Cl)c(Cl)c2)s1
Show InChI InChI=1S/C21H24Cl2N4O3S/c1-21(2,3)16-11-13(19(29)27-8-6-17(28)24-7-9-27)18(31-16)26-20(30)25-12-4-5-14(22)15(23)10-12/h4-5,10-11H,6-9H2,1-3H3,(H,24,28)(H2,25,26,30)
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n/an/a 13n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359349
PNG
(CHEMBL1929228)
Show SMILES Cc1cccc(NC(=O)Nc2sc(cc2C(=O)N2CCNC(=O)CC2)C(C)(C)C)c1
Show InChI InChI=1S/C22H28N4O3S/c1-14-6-5-7-15(12-14)24-21(29)25-19-16(13-17(30-19)22(2,3)4)20(28)26-10-8-18(27)23-9-11-26/h5-7,12-13H,8-11H2,1-4H3,(H,23,27)(H2,24,25,29)
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n/an/a 80n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359350
PNG
(CHEMBL1929229)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(cc2Cl)C#N)s1
Show InChI InChI=1S/C22H24ClN5O3S/c1-22(2,3)17-11-14(20(30)28-8-6-18(29)25-7-9-28)19(32-17)27-21(31)26-16-5-4-13(12-24)10-15(16)23/h4-5,10-11H,6-9H2,1-3H3,(H,25,29)(H2,26,27,31)
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n/an/a 130n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359351
PNG
(CHEMBL1929230)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(F)c(Cl)c2Cl)s1
Show InChI InChI=1S/C21H23Cl2FN4O3S/c1-21(2,3)14-10-11(19(30)28-8-6-15(29)25-7-9-28)18(32-14)27-20(31)26-13-5-4-12(24)16(22)17(13)23/h4-5,10H,6-9H2,1-3H3,(H,25,29)(H2,26,27,31)
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n/an/a 2n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359352
PNG
(CHEMBL1929231)
Show SMILES COCCOCCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C
Show InChI InChI=1S/C26H34Cl2N4O5S/c1-26(2,3)20-16-17(23(38-20)30-25(35)29-19-7-5-6-18(27)22(19)28)24(34)32-9-8-21(33)31(10-11-32)12-13-37-15-14-36-4/h5-7,16H,8-15H2,1-4H3,(H2,29,30,35)
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n/an/a 14n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359353
PNG
(CHEMBL1929232)
Show SMILES COCCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C
Show InChI InChI=1S/C24H30Cl2N4O4S/c1-24(2,3)18-14-15(22(32)30-9-8-19(31)29(10-11-30)12-13-34-4)21(35-18)28-23(33)27-17-7-5-6-16(25)20(17)26/h5-7,14H,8-13H2,1-4H3,(H2,27,28,33)
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n/an/a 140n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359354
PNG
(CHEMBL1929233)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCN(CC(N)=O)C(=O)CC2)c(NC(=O)Nc2cccc(Cl)c2Cl)s1
Show InChI InChI=1S/C23H27Cl2N5O4S/c1-23(2,3)16-11-13(21(33)29-8-7-18(32)30(10-9-29)12-17(26)31)20(35-16)28-22(34)27-15-6-4-5-14(24)19(15)25/h4-6,11H,7-10,12H2,1-3H3,(H2,26,31)(H2,27,28,34)
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n/an/a 13n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359355
PNG
(CHEMBL1929234)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCN(CC3COC(C)(C)O3)C(=O)CC2)c(NC(=O)Nc2cccc(Cl)c2Cl)s1
Show InChI InChI=1S/C27H34Cl2N4O5S/c1-26(2,3)20-13-17(23(39-20)31-25(36)30-19-8-6-7-18(28)22(19)29)24(35)32-10-9-21(34)33(12-11-32)14-16-15-37-27(4,5)38-16/h6-8,13,16H,9-12,14-15H2,1-5H3,(H2,30,31,36)
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n/an/a 31n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50359337
PNG
(CHEMBL1929217)
Show SMILES CC(C)(C)c1cc(C(=O)N2CCNC(=O)CC2)c(NC(=O)Nc2ccc(Cl)cc2)s1
Show InChI InChI=1S/C21H25ClN4O3S/c1-21(2,3)16-12-15(19(28)26-10-8-17(27)23-9-11-26)18(30-16)25-20(29)24-14-6-4-13(22)5-7-14/h4-7,12H,8-11H2,1-3H3,(H,23,27)(H2,24,25,29)
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n/an/a 30n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...


Bioorg Med Chem Lett 21: 7155-65 (2011)

More data for this
Ligand-Target Pair