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15 molecules are shown

Wt: 350.3
BDBM50359690
Wt: 368.3
BDBM50359691
Wt: 384.8
BDBM50359692
Wt: 384.8
BDBM50359693
Wt: 384.8
BDBM50359694
Wt: 368.3
BDBM50359696
Wt: 386.3
BDBM50359697
Wt: 351.3
BDBM50359698
Wt: 382.3
BDBM50359699
Wt: 369.3
BDBM50359700
Wt: 386.3
BDBM50359701
Wt: 404.3
BDBM50359702
Wt: 398.3
BDBM50359703
Wt: 380.3
BDBM50359706
Wt: 416.3
BDBM50359708

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50359690,50359691,50359692,50359693,50359694,50359696,50359697,50359698,50359699,50359700,50359701,50359702,50359703,50359706,50359708   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359690
PNG
(CHEMBL1929434)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccccc2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H18N2O4/c1-3-18(23)17(12-21)19(24)22-14-9-10-15(13-7-5-4-6-8-13)16(11-14)20(25)26-2/h4-11,17H,3H2,1-2H3,(H,22,24)
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n/an/a 73n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Rattus norvegicus (rat))
BDBM50359691
PNG
(CHEMBL1929435)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(F)cc2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H17FN2O4/c1-3-18(24)17(11-22)19(25)23-14-8-9-15(16(10-14)20(26)27-2)12-4-6-13(21)7-5-12/h4-10,17H,3H2,1-2H3,(H,23,25)
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n/an/a 350n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of rat dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359692
PNG
(CHEMBL1929436)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(c(c1)C(=O)OC)-c1ccccc1Cl
Show InChI InChI=1S/C20H17ClN2O4/c1-3-18(24)16(11-22)19(25)23-12-8-9-13(15(10-12)20(26)27-2)14-6-4-5-7-17(14)21/h4-10,16H,3H2,1-2H3,(H,23,25)
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n/an/a 52n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359693
PNG
(CHEMBL1929437)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccc(Cl)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H17ClN2O4/c1-3-18(24)17(11-22)19(25)23-14-7-8-15(16(10-14)20(26)27-2)12-5-4-6-13(21)9-12/h4-10,17H,3H2,1-2H3,(H,23,25)
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n/an/a 31n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359694
PNG
(CHEMBL1929438)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(Cl)cc2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H17ClN2O4/c1-3-18(24)17(11-22)19(25)23-14-8-9-15(16(10-14)20(26)27-2)12-4-6-13(21)7-5-12/h4-10,17H,3H2,1-2H3,(H,23,25)
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n/an/a 45n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359696
PNG
(CHEMBL1929440)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccc(F)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H17FN2O4/c1-3-18(24)17(11-22)19(25)23-14-7-8-15(16(10-14)20(26)27-2)12-5-4-6-13(21)9-12/h4-10,17H,3H2,1-2H3,(H,23,25)
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n/an/a 198n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359697
PNG
(CHEMBL1929441)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(c(c1)C(=O)OC)-c1ccc(F)cc1F
Show InChI InChI=1S/C20H16F2N2O4/c1-3-18(25)16(10-23)19(26)24-12-5-7-13(15(9-12)20(27)28-2)14-6-4-11(21)8-17(14)22/h4-9,16H,3H2,1-2H3,(H,24,26)
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n/an/a 31n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359698
PNG
(CHEMBL1929442)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccnc2)c(c1)C(=O)OC
Show InChI InChI=1S/C19H17N3O4/c1-3-17(23)16(10-20)18(24)22-13-6-7-14(12-5-4-8-21-11-12)15(9-13)19(25)26-2/h4-9,11,16H,3H2,1-2H3,(H,22,24)
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n/an/a 40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359699
PNG
(CHEMBL1929443)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(c(c1)C(=O)OC)-c1ccc(F)cc1C
Show InChI InChI=1S/C21H19FN2O4/c1-4-19(25)18(11-23)20(26)24-14-6-8-16(17(10-14)21(27)28-3)15-7-5-13(22)9-12(15)2/h5-10,18H,4H2,1-3H3,(H,24,26)
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n/an/a 49n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359700
PNG
(CHEMBL1929444)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(F)nc2)c(c1)C(=O)OC
Show InChI InChI=1S/C19H16FN3O4/c1-3-16(24)15(9-21)18(25)23-12-5-6-13(14(8-12)19(26)27-2)11-4-7-17(20)22-10-11/h4-8,10,15H,3H2,1-2H3,(H,23,25)
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n/an/a 150n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359701
PNG
(CHEMBL1929445)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(F)c(F)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H16F2N2O4/c1-3-18(25)15(10-23)19(26)24-12-5-6-13(14(9-12)20(27)28-2)11-4-7-16(21)17(22)8-11/h4-9,15H,3H2,1-2H3,(H,24,26)
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n/an/a 97n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359702
PNG
(CHEMBL1929446)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cc(F)c(F)c(F)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H15F3N2O4/c1-3-17(26)14(9-24)19(27)25-11-4-5-12(13(8-11)20(28)29-2)10-6-15(21)18(23)16(22)7-10/h4-8,14H,3H2,1-2H3,(H,25,27)
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n/an/a 137n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359703
PNG
(CHEMBL1929447)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(c(c1)C(=O)OC)-c1ccc(F)cc1OC
Show InChI InChI=1S/C21H19FN2O5/c1-4-18(25)17(11-23)20(26)24-13-6-8-14(16(10-13)21(27)29-3)15-7-5-12(22)9-19(15)28-2/h5-10,17H,4H2,1-3H3,(H,24,26)
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n/an/a 66n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359706
PNG
(CHEMBL1929450)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccc(OC)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C21H20N2O5/c1-4-19(24)18(12-22)20(25)23-14-8-9-16(17(11-14)21(26)28-3)13-6-5-7-15(10-13)27-2/h5-11,18H,4H2,1-3H3,(H,23,25)
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n/an/a 26n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359708
PNG
(CHEMBL1929452)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2cccc(OC(F)F)c2)c(c1)C(=O)OC
Show InChI InChI=1S/C21H18F2N2O5/c1-3-18(26)17(11-24)19(27)25-13-7-8-15(16(10-13)20(28)29-2)12-5-4-6-14(9-12)30-21(22)23/h4-10,17,21H,3H2,1-2H3,(H,25,27)
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n/an/a 34n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50359691
PNG
(CHEMBL1929435)
Show SMILES CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(F)cc2)c(c1)C(=O)OC
Show InChI InChI=1S/C20H17FN2O4/c1-3-18(24)17(11-22)19(25)23-14-8-9-15(16(10-14)20(26)27-2)12-4-6-13(21)7-5-12/h4-10,17H,3H2,1-2H3,(H,23,25)
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n/an/a 110n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human dihydroorotate dehydrogenase


Bioorg Med Chem Lett 21: 7268-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.052
BindingDB Entry DOI: 10.7270/Q2N87B6R
More data for this
Ligand-Target Pair