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1 similar compounds to monomer 50399676

Compile data set for download or QSAR
Wt: 326.3
BDBM50363451

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50363451   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50363451
PNG
(CHEMBL1946329)
Show SMILES CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1
Show InChI InChI=1S/C17H19FN6/c1-19-16-20-10-14-15(23-16)24(11-6-2-3-7-11)17(22-14)21-13-9-5-4-8-12(13)18/h4-5,8-11H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of full length Hexa-His-tagged JNK1 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation counting


Bioorg Med Chem Lett 22: 1427-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.028
BindingDB Entry DOI: 10.7270/Q2513ZP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50363451
PNG
(CHEMBL1946329)
Show SMILES CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1
Show InChI InChI=1S/C17H19FN6/c1-19-16-20-10-14-15(23-16)24(11-6-2-3-7-11)17(22-14)21-13-9-5-4-8-12(13)18/h4-5,8-11H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of p38alpha using MBP and [gamma33P]ATP as substrate after 60 mins by scintillation counting


Bioorg Med Chem Lett 22: 1427-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.028
BindingDB Entry DOI: 10.7270/Q2513ZP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50363451
PNG
(CHEMBL1946329)
Show SMILES CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1
Show InChI InChI=1S/C17H19FN6/c1-19-16-20-10-14-15(23-16)24(11-6-2-3-7-11)17(22-14)21-13-9-5-4-8-12(13)18/h4-5,8-11H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23)
PDB
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Article
PubMed
n/an/a 680n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of full length Hexa-His-tagged JNK3 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation counting


Bioorg Med Chem Lett 22: 1427-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.028
BindingDB Entry DOI: 10.7270/Q2513ZP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50363451
PNG
(CHEMBL1946329)
Show SMILES CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1
Show InChI InChI=1S/C17H19FN6/c1-19-16-20-10-14-15(23-16)24(11-6-2-3-7-11)17(22-14)21-13-9-5-4-8-12(13)18/h4-5,8-11H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of full length Hexa-His-tagged JNK2 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation counting


Bioorg Med Chem Lett 22: 1427-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.028
BindingDB Entry DOI: 10.7270/Q2513ZP6
More data for this
Ligand-Target Pair