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2 similar compounds to monomer 50365785

Wt: 432.4
BDBM50365787
Wt: 426.4
BDBM50365795

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50365787,50365795   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365787
PNG
(CHEMBL1956566)
Show SMILES NC(=O)c1ccc(cc1F)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H21FN6O2/c24-19-13-15(1-6-18(19)21(25)31)20-14-27-22(23-26-7-8-30(20)23)28-16-2-4-17(5-3-16)29-9-11-32-12-10-29/h1-8,13-14H,9-12H2,(H2,25,31)(H,27,28)
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PubMed
n/an/a 2.39E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Bioorg Med Chem Lett 22: 2266-70 (2012)

More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365795
PNG
(CHEMBL1956574)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C24H22N6O2/c31-24-20-6-1-16(13-17(20)14-27-24)21-15-26-22(23-25-7-8-30(21)23)28-18-2-4-19(5-3-18)29-9-11-32-12-10-29/h1-8,13,15H,9-12,14H2,(H,26,28)(H,27,31)
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PubMed
n/an/a 676n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Bioorg Med Chem Lett 22: 2266-70 (2012)

More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365787
PNG
(CHEMBL1956566)
Show SMILES NC(=O)c1ccc(cc1F)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H21FN6O2/c24-19-13-15(1-6-18(19)21(25)31)20-14-27-22(23-26-7-8-30(20)23)28-16-2-4-17(5-3-16)29-9-11-32-12-10-29/h1-8,13-14H,9-12H2,(H2,25,31)(H,27,28)
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Bioorg Med Chem Lett 22: 2266-70 (2012)

More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365795
PNG
(CHEMBL1956574)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C24H22N6O2/c31-24-20-6-1-16(13-17(20)14-27-24)21-15-26-22(23-25-7-8-30(21)23)28-18-2-4-19(5-3-18)29-9-11-32-12-10-29/h1-8,13,15H,9-12,14H2,(H,26,28)(H,27,31)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 239n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Bioorg Med Chem Lett 22: 2266-70 (2012)

More data for this
Ligand-Target Pair