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6 similar compounds to monomer 50365979

Compile data set for download or QSAR
Wt: 394.4
BDBM50365961
Wt: 420.5
BDBM50365977
Wt: 394.4
BDBM50365978
Wt: 458.5
BDBM50365980
Wt: 442.9
BDBM50365981
Wt: 448.5
BDBM50365982

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50365961,50365977,50365978,50365980,50365981,50365982   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365961
PNG
(CHEMBL1956232)
Show SMILES CCOC1CCN(CC1)c1ccc(cn1)-c1cnnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C22H26N4O3/c1-4-29-16-7-9-26(10-8-16)22-6-5-15(13-23-22)18-14-24-25-19-12-21(28-3)20(27-2)11-17(18)19/h5-6,11-14,16H,4,7-10H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365977
PNG
(CHEMBL1956248)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)C4CC4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H28N4O3/c1-15-10-16(13-25-23(15)28-8-6-24(29,7-9-28)17-4-5-17)19-14-26-27-20-12-22(31-3)21(30-2)11-18(19)20/h10-14,17,29H,4-9H2,1-3H3
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n/an/a 1.80n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365982
PNG
(CHEMBL1956253)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(c3)C3CC3)c2cc1OC
Show InChI InChI=1S/C26H32N4O3/c1-26(2,31)18-7-9-30(10-8-18)25-19(16-5-6-16)11-17(14-27-25)21-15-28-29-22-13-24(33-4)23(32-3)12-20(21)22/h11-16,18,31H,5-10H2,1-4H3
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n/an/a 1.30n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365980
PNG
(CHEMBL1956251)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(c3)C(F)F)c2cc1OC
Show InChI InChI=1S/C24H28F2N4O3/c1-24(2,31)15-5-7-30(8-6-15)23-17(22(25)26)9-14(12-27-23)18-13-28-29-19-11-21(33-4)20(32-3)10-16(18)19/h9-13,15,22,31H,5-8H2,1-4H3
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n/an/a 1.20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365981
PNG
(CHEMBL1956252)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H27ClN4O3/c1-23(2,29)15-5-7-28(8-6-15)22-18(24)9-14(12-25-22)17-13-26-27-19-11-21(31-4)20(30-3)10-16(17)19/h9-13,15,29H,5-8H2,1-4H3
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n/an/a 6.20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365978
PNG
(CHEMBL1956249)
Show SMILES COc1cc2nncc(-c3cnc(N4CCC(C)(O)CC4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C22H26N4O3/c1-14-9-15(12-23-21(14)26-7-5-22(2,27)6-8-26)17-13-24-25-18-11-20(29-4)19(28-3)10-16(17)18/h9-13,27H,5-8H2,1-4H3
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n/an/a 3.20n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair