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18 similar compounds to monomer 50405120

Wt: 362.2
BDBM50367210
Wt: 394.2
BDBM50369231
Wt: 380.2
BDBM50369232
Wt: 452.3
BDBM50369233
Wt: 396.6
BDBM50369234
Wt: 416.2
BDBM50369235
Wt: 450.3
BDBM50369236
Wt: 374.2
BDBM50369237
Wt: 398.2
BDBM50369238
Wt: 378.2
BDBM50369239
Wt: 488.4
BDBM50405113
Wt: 432.3
BDBM50405114
Wt: 424.3
BDBM50405115
Wt: 474.4
BDBM50405117
Wt: 460.4
BDBM50405118
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50367210,50369231,50369232,50369233,50369234,50369235,50369236,50369237,50369238,50369239,50405113,50405114,50405115,50405117,50405118   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369231
PNG
(CHEMBL610230)
Show SMILES OC(O)c1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C11H15N4O10P/c16-5-3(1-24-26(21,22)23)25-10(6(5)17)15-2-12-4-8(15)13-7(11(19)20)14-9(4)18/h2-3,5-6,10-11,16-17,19-20H,1H2,(H,13,14,18)(H2,21,22,23)/t3-,5-,6-,10?/m0/s1
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n/an/a 440n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50369236
PNG
(CHEMBL611912)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(C=Cc1ccccc1)[nH]c2=O
Show InChI InChI=1S/C18H19N4O8P/c23-14-11(8-29-31(26,27)28)30-18(15(14)24)22-9-19-13-16(22)20-12(21-17(13)25)7-6-10-4-2-1-3-5-10/h1-7,9,11,14-15,18,23-24H,8H2,(H,20,21,25)(H2,26,27,28)/t11-,14-,15-,18?/m0/s1
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n/an/a 6.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369233
PNG
(CHEMBL607940)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(CCc1ccccc1)[nH]c2=O
Show InChI InChI=1S/C18H21N4O8P/c23-14-11(8-29-31(26,27)28)30-18(15(14)24)22-9-19-13-16(22)20-12(21-17(13)25)7-6-10-4-2-1-3-5-10/h1-5,9,11,14-15,18,23-24H,6-8H2,(H,20,21,25)(H2,26,27,28)/t11-,14-,15-,18?/m0/s1
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n/an/a 4.60E+5n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369234
PNG
(CHEMBL608491)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(CCl)[nH]c2=O
Show InChI InChI=1S/C11H14ClN4O8P/c12-1-5-14-9-6(10(19)15-5)13-3-16(9)11-8(18)7(17)4(24-11)2-23-25(20,21)22/h3-4,7-8,11,17-18H,1-2H2,(H,14,15,19)(H2,20,21,22)/t4-,7-,8-,11?/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369235
PNG
(CHEMBL610231)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc([nH]c2=O)C(F)(F)F
Show InChI InChI=1S/C11H12F3N4O8P/c12-11(13,14)10-16-7-4(8(21)17-10)15-2-18(7)9-6(20)5(19)3(26-9)1-25-27(22,23)24/h2-3,5-6,9,19-20H,1H2,(H,16,17,21)(H2,22,23,24)/t3-,5-,6-,9?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369236
PNG
(CHEMBL611912)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(C=Cc1ccccc1)[nH]c2=O
Show InChI InChI=1S/C18H19N4O8P/c23-14-11(8-29-31(26,27)28)30-18(15(14)24)22-9-19-13-16(22)20-12(21-17(13)25)7-6-10-4-2-1-3-5-10/h1-7,9,11,14-15,18,23-24H,8H2,(H,20,21,25)(H2,26,27,28)/t11-,14-,15-,18?/m0/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369237
PNG
(CHEMBL607644)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(C=C)[nH]c2=O
Show InChI InChI=1S/C12H15N4O8P/c1-2-6-14-10-7(11(19)15-6)13-4-16(10)12-9(18)8(17)5(24-12)3-23-25(20,21)22/h2,4-5,8-9,12,17-18H,1,3H2,(H,14,15,19)(H2,20,21,22)/t5-,8-,9-,12?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50367210
PNG
(CHEMBL610157)
Show SMILES Cc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C11H15N4O8P/c1-4-13-9-6(10(18)14-4)12-3-15(9)11-8(17)7(16)5(23-11)2-22-24(19,20)21/h3,5,7-8,11,16-17H,2H2,1H3,(H,13,14,18)(H2,19,20,21)/t5-,7-,8-,11?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369238
PNG
(CHEMBL607922)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc([nH]c2=O)C(F)F
Show InChI InChI=1S/C11H13F2N4O8P/c12-7(13)8-15-9-4(10(20)16-8)14-2-17(9)11-6(19)5(18)3(25-11)1-24-26(21,22)23/h2-3,5-7,11,18-19H,1H2,(H,15,16,20)(H2,21,22,23)/t3-,5-,6-,11?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369239
PNG
(CHEMBL607919)
Show SMILES OCc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C11H15N4O9P/c16-1-5-13-9-6(10(19)14-5)12-3-15(9)11-8(18)7(17)4(24-11)2-23-25(20,21)22/h3-4,7-8,11,16-18H,1-2H2,(H,13,14,19)(H2,20,21,22)/t4-,7-,8-,11?/m0/s1
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n/an/a 1.32E+5n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50405113
PNG
(CHEMBL611910)
Show SMILES CCCCCCCCCCc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H33N4O8P/c1-2-3-4-5-6-7-8-9-10-14-22-18-15(19(27)23-14)21-12-24(18)20-17(26)16(25)13(32-20)11-31-33(28,29)30/h12-13,16-17,20,25-26H,2-11H2,1H3,(H,22,23,27)(H2,28,29,30)/t13-,16-,17-,20?/m0/s1
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n/an/a 1.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50405114
PNG
(CHEMBL609561)
Show SMILES CCCCCCc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C16H25N4O8P/c1-2-3-4-5-6-10-18-14-11(15(23)19-10)17-8-20(14)16-13(22)12(21)9(28-16)7-27-29(24,25)26/h8-9,12-13,16,21-22H,2-7H2,1H3,(H,18,19,23)(H2,24,25,26)/t9-,12-,13-,16?/m0/s1
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n/an/a 5.80E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50405115
PNG
(CHEMBL610999)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc([nH]c2=O)-c1ccccc1
Show InChI InChI=1S/C16H17N4O8P/c21-11-9(6-27-29(24,25)26)28-16(12(11)22)20-7-17-10-14(20)18-13(19-15(10)23)8-4-2-1-3-5-8/h1-5,7,9,11-12,16,21-22H,6H2,(H,18,19,23)(H2,24,25,26)/t9-,11-,12-,16?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50405117
PNG
(CHEMBL608363)
Show SMILES CCCCCCCCCc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C19H31N4O8P/c1-2-3-4-5-6-7-8-9-13-21-17-14(18(26)22-13)20-11-23(17)19-16(25)15(24)12(31-19)10-30-32(27,28)29/h11-12,15-16,19,24-25H,2-10H2,1H3,(H,21,22,26)(H2,27,28,29)/t12-,15-,16-,19?/m0/s1
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n/an/a 1.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase


(Escherichia coli (strain K12))
BDBM50405118
PNG
(CHEMBL611601)
Show SMILES CCCCCCCCc1nc2n(cnc2c(=O)[nH]1)C1O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C18H29N4O8P/c1-2-3-4-5-6-7-8-12-20-16-13(17(25)21-12)19-10-22(16)18-15(24)14(23)11(30-18)9-29-31(26,27)28/h10-11,14-15,18,23-24H,2-9H2,1H3,(H,20,21,25)(H2,26,27,28)/t11-,14-,15-,18?/m0/s1
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n/an/a 6.80E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coli


J Med Chem 27: 429-32 (1984)

More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (human))
BDBM50369232
PNG
(CHEMBL607643)
Show SMILES O[C@H]1[C@H](COP(O)(O)=O)OC([C@H]1O)n1cnc2c1nc(CF)[nH]c2=O
Show InChI InChI=1S/C11H14FN4O8P/c12-1-5-14-9-6(10(19)15-5)13-3-16(9)11-8(18)7(17)4(24-11)2-23-25(20,21)22/h3-4,7-8,11,17-18H,1-2H2,(H,14,15,19)(H2,20,21,22)/t4-,7-,8-,11?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Chicago

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay


Citation and Details
More data for this
Ligand-Target Pair