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20 similar compounds to monomer 15244

Wt: 349.3
BDBM50382355
Wt: 414.3
BDBM50382356
Wt: 414.3
BDBM50382357
Wt: 433.2
BDBM50382358
Wt: 400.2
BDBM50382359
Wt: 365.8
BDBM50382364
Wt: 400.2
BDBM50382366
Wt: 400.2
BDBM50382369
Purchase
Wt: 418.2
BDBM50382370
Wt: 418.2
BDBM50382371
Wt: 434.7
BDBM50382372
Wt: 414.3
BDBM50382373
Wt: 428.3
BDBM50382374
Wt: 416.2
BDBM50382375
Wt: 469.1
BDBM50382376
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50382355,50382356,50382357,50382358,50382359,50382364,50382366,50382369,50382370,50382371,50382372,50382373,50382374,50382375,50382376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382355
PNG
(CHEMBL2024353)
Show SMILES Fc1ccc(cc1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12FN3OS/c20-14-8-6-13(7-9-14)18-16-10-11-17(22-23(16)12-21-19(18)24)25-15-4-2-1-3-5-15/h1-12H
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382358
PNG
(CHEMBL324091)
Show SMILES Nc1cc(F)ccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2FN4OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H,23H2
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n/an/a 280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382357
PNG
(CHEMBL326089)
Show SMILES Cc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-2-3-8-16(12)27-17-10-9-15-19(20(26)23-11-25(15)24-17)18-13(21)6-4-7-14(18)22/h2-11H,1H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382358
PNG
(CHEMBL324091)
Show SMILES Nc1cc(F)ccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2FN4OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H,23H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382359
PNG
(CHEMBL2024347)
Show SMILES Clc1ccc(c(Cl)c1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-12-6-7-14(15(21)10-12)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382359
PNG
(CHEMBL2024347)
Show SMILES Clc1ccc(c(Cl)c1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-12-6-7-14(15(21)10-12)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382359
PNG
(CHEMBL2024347)
Show SMILES Clc1ccc(c(Cl)c1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-12-6-7-14(15(21)10-12)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382364
PNG
(CHEMBL2024352)
Show SMILES Clc1ccccc1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12ClN3OS/c20-15-9-5-4-8-14(15)18-16-10-11-17(22-23(16)12-21-19(18)24)25-13-6-2-1-3-7-13/h1-12H
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n/an/a 4.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382364
PNG
(CHEMBL2024352)
Show SMILES Clc1ccccc1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12ClN3OS/c20-15-9-5-4-8-14(15)18-16-10-11-17(22-23(16)12-21-19(18)24)25-13-6-2-1-3-7-13/h1-12H
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382364
PNG
(CHEMBL2024352)
Show SMILES Clc1ccccc1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12ClN3OS/c20-15-9-5-4-8-14(15)18-16-10-11-17(22-23(16)12-21-19(18)24)25-13-6-2-1-3-7-13/h1-12H
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n/an/a 1.99E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382355
PNG
(CHEMBL2024353)
Show SMILES Fc1ccc(cc1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12FN3OS/c20-14-8-6-13(7-9-14)18-16-10-11-17(22-23(16)12-21-19(18)24)25-15-4-2-1-3-5-15/h1-12H
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n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382355
PNG
(CHEMBL2024353)
Show SMILES Fc1ccc(cc1)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H12FN3OS/c20-14-8-6-13(7-9-14)18-16-10-11-17(22-23(16)12-21-19(18)24)25-15-4-2-1-3-5-15/h1-12H
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382366
PNG
(CHEMBL2024527)
Show SMILES Clc1ccc(cc1Cl)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-14-7-6-12(10-15(14)21)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382366
PNG
(CHEMBL2024527)
Show SMILES Clc1ccc(cc1Cl)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-14-7-6-12(10-15(14)21)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382366
PNG
(CHEMBL2024527)
Show SMILES Clc1ccc(cc1Cl)-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-14-7-6-12(10-15(14)21)18-16-8-9-17(23-24(16)11-22-19(18)25)26-13-4-2-1-3-5-13/h1-11H
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382369
PNG
(CHEMBL113806)
Show SMILES Clc1cccc(Cl)c1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-13-7-4-8-14(21)17(13)18-15-9-10-16(23-24(15)11-22-19(18)25)26-12-5-2-1-3-6-12/h1-11H
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382369
PNG
(CHEMBL113806)
Show SMILES Clc1cccc(Cl)c1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-13-7-4-8-14(21)17(13)18-15-9-10-16(23-24(15)11-22-19(18)25)26-12-5-2-1-3-6-12/h1-11H
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382369
PNG
(CHEMBL113806)
Show SMILES Clc1cccc(Cl)c1-c1c2ccc(Sc3ccccc3)nn2cnc1=O
Show InChI InChI=1S/C19H11Cl2N3OS/c20-13-7-4-8-14(21)17(13)18-15-9-10-16(23-24(15)11-22-19(18)25)26-12-5-2-1-3-6-12/h1-11H
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n/an/a 460n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382356
PNG
(CHEMBL114121)
Show SMILES Cc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-7-13(8-6-12)27-17-10-9-16-19(20(26)23-11-25(16)24-17)18-14(21)3-2-4-15(18)22/h2-11H,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382356
PNG
(CHEMBL114121)
Show SMILES Cc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-7-13(8-6-12)27-17-10-9-16-19(20(26)23-11-25(16)24-17)18-14(21)3-2-4-15(18)22/h2-11H,1H3
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n/an/a 870n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382370
PNG
(CHEMBL326629)
Show SMILES Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-2-1-3-14(21)17(13)18-15-8-9-16(24-25(15)10-23-19(18)26)27-12-6-4-11(22)5-7-12/h1-10H
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n/an/a 123n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382370
PNG
(CHEMBL326629)
Show SMILES Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-2-1-3-14(21)17(13)18-15-8-9-16(24-25(15)10-23-19(18)26)27-12-6-4-11(22)5-7-12/h1-10H
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n/an/a 99n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382370
PNG
(CHEMBL326629)
Show SMILES Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-2-1-3-14(21)17(13)18-15-8-9-16(24-25(15)10-23-19(18)26)27-12-6-4-11(22)5-7-12/h1-10H
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n/an/a 293n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382371
PNG
(CHEMBL114962)
Show SMILES Fc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-5-2-6-14(21)17(13)18-15-7-8-16(24-25(15)10-23-19(18)26)27-12-4-1-3-11(22)9-12/h1-10H
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n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382371
PNG
(CHEMBL114962)
Show SMILES Fc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-5-2-6-14(21)17(13)18-15-7-8-16(24-25(15)10-23-19(18)26)27-12-4-1-3-11(22)9-12/h1-10H
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n/an/a 440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382371
PNG
(CHEMBL114962)
Show SMILES Fc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl2FN3OS/c20-13-5-2-6-14(21)17(13)18-15-7-8-16(24-25(15)10-23-19(18)26)27-12-4-1-3-11(22)9-12/h1-10H
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n/an/a 720n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382372
PNG
(CHEMBL114430)
Show SMILES Clc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl3N3OS/c20-11-3-1-4-12(9-11)27-16-8-7-15-18(19(26)23-10-25(15)24-16)17-13(21)5-2-6-14(17)22/h1-10H
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n/an/a 280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382372
PNG
(CHEMBL114430)
Show SMILES Clc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl3N3OS/c20-11-3-1-4-12(9-11)27-16-8-7-15-18(19(26)23-10-25(15)24-16)17-13(21)5-2-6-14(17)22/h1-10H
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n/an/a 350n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382372
PNG
(CHEMBL114430)
Show SMILES Clc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C19H10Cl3N3OS/c20-11-3-1-4-12(9-11)27-16-8-7-15-18(19(26)23-10-25(15)24-16)17-13(21)5-2-6-14(17)22/h1-10H
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382373
PNG
(CHEMBL324089)
Show SMILES Cc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-4-2-5-13(10-12)27-17-9-8-16-19(20(26)23-11-25(16)24-17)18-14(21)6-3-7-15(18)22/h2-11H,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382373
PNG
(CHEMBL324089)
Show SMILES Cc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-4-2-5-13(10-12)27-17-9-8-16-19(20(26)23-11-25(16)24-17)18-14(21)6-3-7-15(18)22/h2-11H,1H3
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n/an/a 210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382373
PNG
(CHEMBL324089)
Show SMILES Cc1cccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-4-2-5-13(10-12)27-17-9-8-16-19(20(26)23-11-25(16)24-17)18-14(21)6-3-7-15(18)22/h2-11H,1H3
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n/an/a 280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382374
PNG
(CHEMBL2024530)
Show SMILES CCc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C21H15Cl2N3OS/c1-2-13-6-3-4-9-17(13)28-18-11-10-16-20(21(27)24-12-26(16)25-18)19-14(22)7-5-8-15(19)23/h3-12H,2H2,1H3
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n/an/a 750n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382374
PNG
(CHEMBL2024530)
Show SMILES CCc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C21H15Cl2N3OS/c1-2-13-6-3-4-9-17(13)28-18-11-10-16-20(21(27)24-12-26(16)25-18)19-14(22)7-5-8-15(19)23/h3-12H,2H2,1H3
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n/an/a 980n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382374
PNG
(CHEMBL2024530)
Show SMILES CCc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C21H15Cl2N3OS/c1-2-13-6-3-4-9-17(13)28-18-11-10-16-20(21(27)24-12-26(16)25-18)19-14(22)7-5-8-15(19)23/h3-12H,2H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382357
PNG
(CHEMBL326089)
Show SMILES Cc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-2-3-8-16(12)27-17-10-9-15-19(20(26)23-11-25(15)24-17)18-13(21)6-4-7-14(18)22/h2-11H,1H3
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382357
PNG
(CHEMBL326089)
Show SMILES Cc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-2-3-8-16(12)27-17-10-9-15-19(20(26)23-11-25(15)24-17)18-13(21)6-4-7-14(18)22/h2-11H,1H3
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n/an/a 330n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382375
PNG
(CHEMBL117211)
Show SMILES Oc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2N3O2S/c20-11-4-3-5-12(21)17(11)18-13-8-9-16(23-24(13)10-22-19(18)26)27-15-7-2-1-6-14(15)25/h1-10,25H
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n/an/a 360n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382375
PNG
(CHEMBL117211)
Show SMILES Oc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2N3O2S/c20-11-4-3-5-12(21)17(11)18-13-8-9-16(23-24(13)10-22-19(18)26)27-15-7-2-1-6-14(15)25/h1-10,25H
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n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382375
PNG
(CHEMBL117211)
Show SMILES Oc1ccccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2N3O2S/c20-11-4-3-5-12(21)17(11)18-13-8-9-16(23-24(13)10-22-19(18)26)27-15-7-2-1-6-14(15)25/h1-10,25H
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n/an/a 490n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382376
PNG
(CHEMBL114057)
Show SMILES Clc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1Cl
Show InChI InChI=1S/C19H9Cl4N3OS/c20-11-5-4-10(8-14(11)23)28-16-7-6-15-18(19(27)24-9-26(15)25-16)17-12(21)2-1-3-13(17)22/h1-9H
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n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382376
PNG
(CHEMBL114057)
Show SMILES Clc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1Cl
Show InChI InChI=1S/C19H9Cl4N3OS/c20-11-5-4-10(8-14(11)23)28-16-7-6-15-18(19(27)24-9-26(15)25-16)17-12(21)2-1-3-13(17)22/h1-9H
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n/an/a 970n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382376
PNG
(CHEMBL114057)
Show SMILES Clc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1Cl
Show InChI InChI=1S/C19H9Cl4N3OS/c20-11-5-4-10(8-14(11)23)28-16-7-6-15-18(19(27)24-9-26(15)25-16)17-12(21)2-1-3-13(17)22/h1-9H
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382358
PNG
(CHEMBL324091)
Show SMILES Nc1cc(F)ccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1
Show InChI InChI=1S/C19H11Cl2FN4OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H,23H2
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n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assay


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50382356
PNG
(CHEMBL114121)
Show SMILES Cc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)cc1
Show InChI InChI=1S/C20H13Cl2N3OS/c1-12-5-7-13(8-6-12)27-17-10-9-16-19(20(26)23-11-25(16)24-17)18-14(21)3-2-4-15(18)22/h2-11H,1H3
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n/an/a 370n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISA


ACS Med Chem Lett 2: 758-763 (2011)


Article DOI: 10.1021/ml2001455
BindingDB Entry DOI: 10.7270/Q26D5V19
More data for this
Ligand-Target Pair