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7 similar compounds to monomer 50384720

Wt: 742.8
BDBM50384722
Wt: 658.6
BDBM50384723
Wt: 728.8
BDBM50384724
Wt: 611.6
BDBM50384728
Wt: 616.6
BDBM50384731
Wt: 586.6
BDBM50384734
Wt: 532.6
BDBM50384735

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50384722,50384723,50384724,50384728,50384731,50384734,50384735   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384722
PNG
(CHEMBL2037223)
Show SMILES CN(C)CCCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3cc(Nc4cccc(NC(=O)c5cc(cc(c5)C(F)(F)F)N5CCN(C)CC5)c4)ccc23)c1C
Show InChI InChI=1S/C40H45F3N8O3/c1-24-34(45-25(2)36(24)39(54)44-12-7-13-49(3)4)23-33-32-11-10-30(22-35(32)48-38(33)53)46-28-8-6-9-29(21-28)47-37(52)26-18-27(40(41,42)43)20-31(19-26)51-16-14-50(5)15-17-51/h6,8-11,18-23,45-46H,7,12-17H2,1-5H3,(H,44,54)(H,47,52)(H,48,53)/b33-23-
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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 3.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FMS in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384724
PNG
(CHEMBL2037221)
Show SMILES CCN(CC)CCNC(=O)c1c[nH]c(\C=C2/C(=O)Nc3cc(Nc4cccc(NC(=O)c5cc(cc(c5)C(F)(F)F)N5CCN(C)CC5)c4)ccc23)c1
Show InChI InChI=1S/C39H43F3N8O3/c1-4-49(5-2)12-11-43-36(51)26-18-31(44-24-26)22-34-33-10-9-30(23-35(33)47-38(34)53)45-28-7-6-8-29(21-28)46-37(52)25-17-27(39(40,41)42)20-32(19-25)50-15-13-48(3)14-16-50/h6-10,17-24,44-45H,4-5,11-16H2,1-3H3,(H,43,51)(H,46,52)(H,47,53)/b34-22-
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n/an/a 19n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384724
PNG
(CHEMBL2037221)
Show SMILES CCN(CC)CCNC(=O)c1c[nH]c(\C=C2/C(=O)Nc3cc(Nc4cccc(NC(=O)c5cc(cc(c5)C(F)(F)F)N5CCN(C)CC5)c4)ccc23)c1
Show InChI InChI=1S/C39H43F3N8O3/c1-4-49(5-2)12-11-43-36(51)26-18-31(44-24-26)22-34-33-10-9-30(23-35(33)47-38(34)53)45-28-7-6-8-29(21-28)46-37(52)25-17-27(39(40,41)42)20-32(19-25)50-15-13-48(3)14-16-50/h6-10,17-24,44-45H,4-5,11-16H2,1-3H3,(H,43,51)(H,46,52)(H,47,53)/b34-22-
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384728
PNG
(CHEMBL2037218)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C#N)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H28F3N7O2/c1-42-7-9-43(10-8-42)27-13-21(12-22(14-27)33(34,35)36)31(44)40-24-4-2-3-23(15-24)39-25-5-6-28-29(32(45)41-30(28)17-25)16-26-11-20(18-37)19-38-26/h2-6,11-17,19,38-39H,7-10H2,1H3,(H,40,44)(H,41,45)/b29-16-
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384731
PNG
(CHEMBL2037214)
Show SMILES OCCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H31F3N6O3/c34-33(35,36)22-15-21(16-27(17-22)42-11-9-41(10-12-42)13-14-43)31(44)39-25-4-1-3-24(18-25)38-26-6-7-28-29(19-23-5-2-8-37-23)32(45)40-30(28)20-26/h1-8,15-20,37-38,43H,9-14H2,(H,39,44)(H,40,45)/b29-19-
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n/an/a 35n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384731
PNG
(CHEMBL2037214)
Show SMILES OCCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H31F3N6O3/c34-33(35,36)22-15-21(16-27(17-22)42-11-9-41(10-12-42)13-14-43)31(44)39-25-4-1-3-24(18-25)38-26-6-7-28-29(19-23-5-2-8-37-23)32(45)40-30(28)20-26/h1-8,15-20,37-38,43H,9-14H2,(H,39,44)(H,40,45)/b29-19-
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n/an/a 68n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused ROS in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused ZAP70 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor Tie-1


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused TIE1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 4.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused RON in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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TBA

Assay Description
Inhibition of Tel-fused RET in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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TBA

Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused LYN in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
TPR/MET fusion protein


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 500n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused KIT in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
JNK1/JNK2


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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TBA

Assay Description
Inhibition of Tel-fused JNK2 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused IGF1R in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 3.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 4.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused BMX in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50384735
PNG
(CHEMBL2037210)
Show SMILES CN1CCN(CC1)c1cc(C)cc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H32N6O2/c1-21-15-22(17-27(16-21)38-13-11-37(2)12-14-38)31(39)35-25-6-3-5-24(18-25)34-26-8-9-28-29(19-23-7-4-10-33-23)32(40)36-30(28)20-26/h3-10,15-20,33-34H,11-14H2,1-2H3,(H,35,39)(H,36,40)/b29-19-
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n/an/a 97n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKC by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384735
PNG
(CHEMBL2037210)
Show SMILES CN1CCN(CC1)c1cc(C)cc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H32N6O2/c1-21-15-22(17-27(16-21)38-13-11-37(2)12-14-38)31(39)35-25-6-3-5-24(18-25)34-26-8-9-28-29(19-23-7-4-10-33-23)32(40)36-30(28)20-26/h3-10,15-20,33-34H,11-14H2,1-2H3,(H,35,39)(H,36,40)/b29-19-
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384723
PNG
(CHEMBL2037222)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4[nH]c(C)c(C(O)=O)c4C)C(=O)Nc3c2)c1
Show InChI InChI=1S/C35H33F3N6O4/c1-19-29(39-20(2)31(19)34(47)48)18-28-27-8-7-25(17-30(27)42-33(28)46)40-23-5-4-6-24(16-23)41-32(45)21-13-22(35(36,37)38)15-26(14-21)44-11-9-43(3)10-12-44/h4-8,13-18,39-40H,9-12H2,1-3H3,(H,41,45)(H,42,46)(H,47,48)/b28-18-
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair