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8 similar compounds to monomer 50384726

Wt: 316.3
BDBM50384730
Wt: 616.6
BDBM50384731
Wt: 587.5
BDBM50384732
Wt: 586.6
BDBM50384733
Wt: 586.6
BDBM50384734
Wt: 532.6
BDBM50384735
Wt: 420.4
BDBM50384737
Wt: 358.3
BDBM50384738

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50384730,50384731,50384732,50384733,50384734,50384735,50384737,50384738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50384730
PNG
(CHEMBL2037216)
Show SMILES Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C19H16N4O/c20-12-3-1-4-14(9-12)22-15-6-7-16-17(10-13-5-2-8-21-13)19(24)23-18(16)11-15/h1-11,21-22H,20H2,(H,23,24)/b17-10-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKC by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50384738
PNG
(CHEMBL2037193)
Show SMILES CC(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C21H18N4O2/c1-13(26)23-15-4-2-5-16(10-15)24-17-7-8-18-19(11-14-6-3-9-22-14)21(27)25-20(18)12-17/h2-12,22,24H,1H3,(H,23,26)(H,25,27)/b19-11-
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n/an/a 1.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKC by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384731
PNG
(CHEMBL2037214)
Show SMILES OCCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H31F3N6O3/c34-33(35,36)22-15-21(16-27(17-22)42-11-9-41(10-12-42)13-14-43)31(44)39-25-4-1-3-24(18-25)38-26-6-7-28-29(19-23-5-2-8-37-23)32(45)40-30(28)20-26/h1-8,15-20,37-38,43H,9-14H2,(H,39,44)(H,40,45)/b29-19-
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n/an/a 68n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384732
PNG
(CHEMBL2037213)
Show SMILES OC1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H28F3N5O3/c33-32(34,35)20-13-19(14-25(15-20)40-11-8-26(41)9-12-40)30(42)38-23-4-1-3-22(16-23)37-24-6-7-27-28(17-21-5-2-10-36-21)31(43)39-29(27)18-24/h1-7,10,13-18,26,36-37,41H,8-9,11-12H2,(H,38,42)(H,39,43)/b28-17-
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n/an/a 60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384732
PNG
(CHEMBL2037213)
Show SMILES OC1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H28F3N5O3/c33-32(34,35)20-13-19(14-25(15-20)40-11-8-26(41)9-12-40)30(42)38-23-4-1-3-22(16-23)37-24-6-7-27-28(17-21-5-2-10-36-21)31(43)39-29(27)18-24/h1-7,10,13-18,26,36-37,41H,8-9,11-12H2,(H,38,42)(H,39,43)/b28-17-
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384733
PNG
(CHEMBL2037212)
Show SMILES CN1CCN(CC1)c1ccc(cc1C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-12-14-41(15-13-40)29-10-7-20(16-27(29)32(33,34)35)30(42)38-23-5-2-4-22(17-23)37-24-8-9-25-26(18-21-6-3-11-36-21)31(43)39-28(25)19-24/h2-11,16-19,36-37H,12-15H2,1H3,(H,38,42)(H,39,43)/b26-18-
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused ROS in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused ZAP70 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor Tie-1


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused TIE1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 4.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused RON in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 800n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused RET in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 200n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused LYN in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
TPR/MET fusion protein


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 500n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused KIT in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
JNK1/JNK2


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused JNK2 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused IGF1R in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 6.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 3.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 4.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused BMX in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))
BDBM50384735
PNG
(CHEMBL2037210)
Show SMILES CN1CCN(CC1)c1cc(C)cc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H32N6O2/c1-21-15-22(17-27(16-21)38-13-11-37(2)12-14-38)31(39)35-25-6-3-5-24(18-25)34-26-8-9-28-29(19-23-7-4-10-33-23)32(40)36-30(28)20-26/h3-10,15-20,33-34H,11-14H2,1-2H3,(H,35,39)(H,36,40)/b29-19-
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n/an/a 97n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKC by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384735
PNG
(CHEMBL2037210)
Show SMILES CN1CCN(CC1)c1cc(C)cc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H32N6O2/c1-21-15-22(17-27(16-21)38-13-11-37(2)12-14-38)31(39)35-25-6-3-5-24(18-25)34-26-8-9-28-29(19-23-7-4-10-33-23)32(40)36-30(28)20-26/h3-10,15-20,33-34H,11-14H2,1-2H3,(H,35,39)(H,36,40)/b29-19-
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 3.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FMS in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo Sapiens)
BDBM50384737
PNG
(CHEMBL2037194)
Show SMILES O=C(Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1)c1ccccc1
Show InChI InChI=1S/C26H20N4O2/c31-25(17-6-2-1-3-7-17)29-20-9-4-8-19(14-20)28-21-11-12-22-23(15-18-10-5-13-27-18)26(32)30-24(22)16-21/h1-16,27-28H,(H,29,31)(H,30,32)/b23-15-
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n/an/a 160n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKA by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2


(Homo sapiens (Human))
BDBM50384731
PNG
(CHEMBL2037214)
Show SMILES OCCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H31F3N6O3/c34-33(35,36)22-15-21(16-27(17-22)42-11-9-41(10-12-42)13-14-43)31(44)39-25-4-1-3-24(18-25)38-26-6-7-28-29(19-23-5-2-8-37-23)32(45)40-30(28)20-26/h1-8,15-20,37-38,43H,9-14H2,(H,39,44)(H,40,45)/b29-19-
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n/an/a 35n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TRKB by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair