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1 similar compounds to monomer 50386948

Compile data set for download or QSAR
Wt: 481.9
BDBM50386949

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50386949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Homo sapiens (Human))
BDBM50386949
PNG
(CHEMBL2048814)
Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4Cl)-n4nccn4)C3)CC2)cc1
Show InChI InChI=1S/C25H28ClN5O3/c1-33-21-4-6-22(7-5-21)34-16-24(32)30-12-8-25(9-13-30)17-29(18-25)15-19-2-3-20(14-23(19)26)31-27-10-11-28-31/h2-7,10-11,14H,8-9,12-13,15-18H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA


Bioorg Med Chem Lett 22: 4281-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50386949
PNG
(CHEMBL2048814)
Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4Cl)-n4nccn4)C3)CC2)cc1
Show InChI InChI=1S/C25H28ClN5O3/c1-33-21-4-6-22(7-5-21)34-16-24(32)30-12-8-25(9-13-30)17-29(18-25)15-19-2-3-20(14-23(19)26)31-27-10-11-28-31/h2-7,10-11,14H,8-9,12-13,15-18H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA


Bioorg Med Chem Lett 22: 4281-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D
More data for this
Ligand-Target Pair