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10 similar compounds to monomer 50408827

Wt: 364.4
BDBM50408825
Wt: 350.4
BDBM50408826
Wt: 336.4
BDBM50408828
Wt: 378.5
BDBM50408830
Wt: 296.4
BDBM50408833
Wt: 394.5
BDBM50408834
Wt: 436.5
BDBM50408837
Wt: 378.5
BDBM50408844
Wt: 406.5
BDBM50408845
Wt: 420.5
BDBM50408846

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50408825,50408826,50408828,50408830,50408833,50408834,50408837,50408844,50408845,50408846   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408825
PNG
(CHEMBL158729)
Show SMILES CN1CC(COC(=O)C2CCCCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
Show InChI InChI=1S/C23H28N2O2/c1-25-13-15(14-27-23(26)16-6-3-2-4-7-16)10-19-18-8-5-9-20-22(18)17(12-24-20)11-21(19)25/h5,8-10,12,16,19,21,24H,2-4,6-7,11,13-14H2,1H3/t19-,21-/m1/s1
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n/an/an/a 39.8n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408826
PNG
(CHEMBL160469)
Show SMILES CN1CC(COC(=O)C2CCCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
Show InChI InChI=1S/C22H26N2O2/c1-24-12-14(13-26-22(25)15-5-2-3-6-15)9-18-17-7-4-8-19-21(17)16(11-23-19)10-20(18)24/h4,7-9,11,15,18,20,23H,2-3,5-6,10,12-13H2,1H3/t18-,20-/m1/s1
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n/an/an/a 49.0n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408828
PNG
(CHEMBL351362)
Show SMILES CN1CC(COC(=O)C2CCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
Show InChI InChI=1S/C21H24N2O2/c1-23-11-13(12-25-21(24)14-4-2-5-14)8-17-16-6-3-7-18-20(16)15(10-22-18)9-19(17)23/h3,6-8,10,14,17,19,22H,2,4-5,9,11-12H2,1H3/t17-,19-/m1/s1
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n/an/an/a 77.6n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408830
PNG
(CHEMBL348055)
Show SMILES CC(C)n1cc2C[C@@H]3[C@H](C=C(COC(=O)C4CCC4)CN3C)c3cccc1c23
Show InChI InChI=1S/C24H30N2O2/c1-15(2)26-13-18-11-22-20(19-8-5-9-21(26)23(18)19)10-16(12-25(22)3)14-28-24(27)17-6-4-7-17/h5,8-10,13,15,17,20,22H,4,6-7,11-12,14H2,1-3H3/t20-,22-/m1/s1
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n/an/an/a 9.33n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50408833
PNG
(CHEMBL349405)
Show SMILES CC(C)n1cc2C[C@@H]3[C@H](C=C(CO)CN3C)c3cccc1c23
Show InChI InChI=1S/C19H24N2O/c1-12(2)21-10-14-8-18-16(7-13(11-22)9-20(18)3)15-5-4-6-17(21)19(14)15/h4-7,10,12,16,18,22H,8-9,11H2,1-3H3/t16-,18-/m1/s1
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n/an/an/a 851n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Affinity of compound towards 5-hydroxytryptamine 1B receptor in isolated guinea-pig iliac artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408834
PNG
(CHEMBL346565)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)OCC1=C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1
Show InChI InChI=1S/C24H30N2O3/c1-26-13-15(14-29-24(27)16-6-8-18(28-2)9-7-16)10-20-19-4-3-5-21-23(19)17(12-25-21)11-22(20)26/h3-5,10,12,16,18,20,22,25H,6-9,11,13-14H2,1-2H3/t16-,18-,20-,22-/m1/s1
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n/an/an/a 57.5n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408834
PNG
(CHEMBL346565)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)OCC1=C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1
Show InChI InChI=1S/C24H30N2O3/c1-26-13-15(14-29-24(27)16-6-8-18(28-2)9-7-16)10-20-19-4-3-5-21-23(19)17(12-25-21)11-22(20)26/h3-5,10,12,16,18,20,22,25H,6-9,11,13-14H2,1-2H3/t16-,18-,20-,22-/m1/s1
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n/an/an/a 47.9n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408837
PNG
(CHEMBL434841)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)OCC1=C[C@H]2[C@@H](Cc3cn(C(C)C)c4cccc2c34)N(C)C1
Show InChI InChI=1S/C27H36N2O3/c1-17(2)29-15-20-13-25-23(22-6-5-7-24(29)26(20)22)12-18(14-28(25)3)16-32-27(30)19-8-10-21(31-4)11-9-19/h5-7,12,15,17,19,21,23,25H,8-11,13-14,16H2,1-4H3/t19-,21-,23-,25-/m1/s1
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n/an/an/a 11.5n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408833
PNG
(CHEMBL349405)
Show SMILES CC(C)n1cc2C[C@@H]3[C@H](C=C(CO)CN3C)c3cccc1c23
Show InChI InChI=1S/C19H24N2O/c1-12(2)21-10-14-8-18-16(7-13(11-22)9-20(18)3)15-5-4-6-17(21)19(14)15/h4-7,10,12,16,18,22H,8-9,11H2,1-3H3/t16-,18-/m1/s1
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n/an/an/a 0.724n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408844
PNG
(CHEMBL160721)
Show SMILES CN1CC(COC(=O)C2CCCCCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
Show InChI InChI=1S/C24H30N2O2/c1-26-14-16(15-28-24(27)17-7-4-2-3-5-8-17)11-20-19-9-6-10-21-23(19)18(13-25-21)12-22(20)26/h6,9-11,13,17,20,22,25H,2-5,7-8,12,14-15H2,1H3/t20-,22-/m1/s1
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n/an/an/a 10.7n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408845
PNG
(CHEMBL159165)
Show SMILES CC(C)n1cc2C[C@@H]3[C@H](C=C(COC(=O)C4CCCCC4)CN3C)c3cccc1c23
Show InChI InChI=1S/C26H34N2O2/c1-17(2)28-15-20-13-24-22(21-10-7-11-23(28)25(20)21)12-18(14-27(24)3)16-30-26(29)19-8-5-4-6-9-19/h7,10-12,15,17,19,22,24H,4-6,8-9,13-14,16H2,1-3H3/t22-,24-/m1/s1
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n/an/an/a 15.8n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408846
PNG
(CHEMBL160158)
Show SMILES CC(C)n1cc2C[C@@H]3[C@H](C=C(COC(=O)C4CCCCCC4)CN3C)c3cccc1c23
Show InChI InChI=1S/C27H36N2O2/c1-18(2)29-16-21-14-25-23(22-11-8-12-24(29)26(21)22)13-19(15-28(25)3)17-31-27(30)20-9-6-4-5-7-10-20/h8,11-13,16,18,20,23,25H,4-7,9-10,14-15,17H2,1-3H3/t23-,25-/m1/s1
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n/an/an/a 17.0n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50408837
PNG
(CHEMBL434841)
Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)OCC1=C[C@H]2[C@@H](Cc3cn(C(C)C)c4cccc2c34)N(C)C1
Show InChI InChI=1S/C27H36N2O3/c1-17(2)29-15-20-13-25-23(22-6-5-7-24(29)26(20)22)12-18(14-28(25)3)16-32-27(30)19-8-10-21(31-4)11-9-19/h5-7,12,15,17,19,21,23,25H,8-11,13-14,16H2,1-4H3/t19-,21-,23-,25-/m1/s1
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n/an/an/a 7.41n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Blocking 5-HT2A receptor-mediated contractions of rat tail artery


J Med Chem 42: 659-68 (1999)


Article DOI: 10.1021/jm981092u
BindingDB Entry DOI: 10.7270/Q21J9C0D
More data for this
Ligand-Target Pair