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2 similar compounds to monomer 50416396

Wt: 382.4
BDBM50416409
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Wt: 378.4
BDBM50416410
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50416409,50416410   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (human))
BDBM50416410
PNG
(CHEMBL1210458)
Show SMILES Cc1ccc(NC(=O)c2cc(c(s2)N2CCOCC2)-c2ccccc2)cc1
Show InChI InChI=1S/C22H22N2O2S/c1-16-7-9-18(10-8-16)23-21(25)20-15-19(17-5-3-2-4-6-17)22(27-20)24-11-13-26-14-12-24/h2-10,15H,11-14H2,1H3,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.26E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 20: 4561-5 (2010)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (human))
BDBM50416409
PNG
(CHEMBL1210702)
Show SMILES Fc1ccc(NC(=O)c2cc(c(s2)N2CCOCC2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19FN2O2S/c22-16-6-8-17(9-7-16)23-20(25)19-14-18(15-4-2-1-3-5-15)21(27-19)24-10-12-26-13-11-24/h1-9,14H,10-13H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.26E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 20: 4561-5 (2010)

More data for this
Ligand-Target Pair