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5 similar compounds to monomer 50431242

Compile data set for download or QSAR
Wt: 277.0
BDBM50431243
Wt: 325.5
BDBM50431236
Wt: 309.1
BDBM50431237
Wt: 325.5
BDBM50431238
Wt: 309.1
BDBM50431239

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50431243,50431236,50431237,50431238,50431239   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431236
PNG
(CHEMBL2332618)
Show SMILES C[C@@H](NC(=O)c1ccnc(Cl)c1)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BClN3O4/c1-8(13(20)18-6-2-3-10(18)14(21)22)17-12(19)9-4-5-16-11(15)7-9/h4-5,7-8,10,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,10+/m1/s1
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PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431237
PNG
(CHEMBL2332617)
Show SMILES C[C@@H](NC(=O)c1ccnc(F)c1)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BFN3O4/c1-8(13(20)18-6-2-3-10(18)14(21)22)17-12(19)9-4-5-16-11(15)7-9/h4-5,7-8,10,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,10+/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431238
PNG
(CHEMBL2333030)
Show SMILES C[C@@H](NC(=O)c1ccncc1Cl)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BClN3O4/c1-8(13(20)18-6-2-3-11(18)14(21)22)17-12(19)9-4-5-16-7-10(9)15/h4-5,7-8,11,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,11+/m1/s1
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n/an/a 640n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431239
PNG
(CHEMBL2333029)
Show SMILES C[C@@H](NC(=O)c1ccncc1F)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BFN3O4/c1-8(13(20)18-6-2-3-11(18)14(21)22)17-12(19)9-4-5-16-7-10(9)15/h4-5,7-8,11,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,11+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431243
PNG
(CHEMBL2333025)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccncc1
Show InChI InChI=1S/C12H16BN3O4/c17-11(16-7-1-2-10(16)13(19)20)8-15-12(18)9-3-5-14-6-4-9/h3-6,10,19-20H,1-2,7-8H2,(H,15,18)/t10-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431236
PNG
(CHEMBL2332618)
Show SMILES C[C@@H](NC(=O)c1ccnc(Cl)c1)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BClN3O4/c1-8(13(20)18-6-2-3-10(18)14(21)22)17-12(19)9-4-5-16-11(15)7-9/h4-5,7-8,10,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,10+/m1/s1
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n/an/a 9.40n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50431243
PNG
(CHEMBL2333025)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccncc1
Show InChI InChI=1S/C12H16BN3O4/c17-11(16-7-1-2-10(16)13(19)20)8-15-12(18)9-3-5-14-6-4-9/h3-6,10,19-20H,1-2,7-8H2,(H,15,18)/t10-/m0/s1
PDB
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n/an/a 2.80E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431238
PNG
(CHEMBL2333030)
Show SMILES C[C@@H](NC(=O)c1ccncc1Cl)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BClN3O4/c1-8(13(20)18-6-2-3-11(18)14(21)22)17-12(19)9-4-5-16-7-10(9)15/h4-5,7-8,11,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,11+/m1/s1
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n/an/a 3.40n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431239
PNG
(CHEMBL2333029)
Show SMILES C[C@@H](NC(=O)c1ccncc1F)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BFN3O4/c1-8(13(20)18-6-2-3-11(18)14(21)22)17-12(19)9-4-5-16-7-10(9)15/h4-5,7-8,11,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,11+/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431243
PNG
(CHEMBL2333025)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccncc1
Show InChI InChI=1S/C12H16BN3O4/c17-11(16-7-1-2-10(16)13(19)20)8-15-12(18)9-3-5-14-6-4-9/h3-6,10,19-20H,1-2,7-8H2,(H,15,18)/t10-/m0/s1
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n/an/a 0.470n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50431243
PNG
(CHEMBL2333025)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccncc1
Show InChI InChI=1S/C12H16BN3O4/c17-11(16-7-1-2-10(16)13(19)20)8-15-12(18)9-3-5-14-6-4-9/h3-6,10,19-20H,1-2,7-8H2,(H,15,18)/t10-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50431243
PNG
(CHEMBL2333025)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccncc1
Show InChI InChI=1S/C12H16BN3O4/c17-11(16-7-1-2-10(16)13(19)20)8-15-12(18)9-3-5-14-6-4-9/h3-6,10,19-20H,1-2,7-8H2,(H,15,18)/t10-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431237
PNG
(CHEMBL2332617)
Show SMILES C[C@@H](NC(=O)c1ccnc(F)c1)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C13H17BFN3O4/c1-8(13(20)18-6-2-3-10(18)14(21)22)17-12(19)9-4-5-16-11(15)7-9/h4-5,7-8,10,21-22H,2-3,6H2,1H3,(H,17,19)/t8-,10+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair