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4 similar compounds to monomer 50431947

Compile data set for download or QSAR
Wt: 412.2
BDBM50431930
Wt: 333.3
BDBM50431931
Wt: 346.4
BDBM50431944
Wt: 426.3
BDBM50431948

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50431930,50431931,50431944,50431948   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431930
PNG
(CHEMBL2348078)
Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(Br)cn1
Show InChI InChI=1S/C14H10BrN3O3S2/c15-7-1-2-8(16-5-7)14-9(3-13(20)21)23-12(18-14)4-11-17-10(19)6-22-11/h1-2,4-5H,3,6H2,(H,17,19)(H,20,21)/b11-4+
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n/an/a 840n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431948
PNG
(CHEMBL2348092)
Show SMILES OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(Br)cn1
Show InChI InChI=1S/C15H12BrN3O3S2/c16-8-1-2-9(17-6-8)15-10(3-4-14(21)22)24-13(19-15)5-12-18-11(20)7-23-12/h1-2,5-6H,3-4,7H2,(H,18,20)(H,21,22)/b12-5+
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n/an/a 630n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431944
PNG
(CHEMBL2348087)
Show SMILES OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C16H14N2O3S2/c19-12-9-22-13(17-12)8-14-18-16(10-4-2-1-3-5-10)11(23-14)6-7-15(20)21/h1-5,8H,6-7,9H2,(H,17,19)(H,20,21)/b13-8+
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n/an/a 420n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431931
PNG
(CHEMBL2348077)
Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccn1
Show InChI InChI=1S/C14H11N3O3S2/c18-10-7-21-11(16-10)6-12-17-14(8-3-1-2-4-15-8)9(22-12)5-13(19)20/h1-4,6H,5,7H2,(H,16,18)(H,19,20)/b11-6+
PDB
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n/an/a 400n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair