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23 similar compounds to monomer 50435201

Compile data set for download or QSAR
Wt: 506.4
BDBM50433376
Wt: 512.4
BDBM50435187
Wt: 496.4
BDBM50435188
Wt: 531.4
BDBM50435190
Wt: 540.9
BDBM50435191
Wt: 522.4
BDBM50435192
Wt: 534.5
BDBM50435193
Wt: 520.4
BDBM50435194
Wt: 506.4
BDBM50435195
Wt: 492.4
BDBM50435196
Wt: 478.4
BDBM50435197
Wt: 548.5
BDBM50435199
Wt: 534.4
BDBM50435200
Wt: 506.4
BDBM50435202
Wt: 492.4
BDBM50435203
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50433376,50435187,50435188,50435190,50435191,50435192,50435193,50435194,50435195,50435196,50435197,50435199,50435200,50435202,50435203   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433376
PNG
(CHEMBL2375627)
Show SMILES Cc1nc(nc(NC[C@@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m1/s1
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n/an/an/an/a 430n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Co2+


J Med Chem 56: 3996-4016 (2013)


Article DOI: 10.1021/jm400227z
BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435203
PNG
(CHEMBL2390976)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)Cc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c1-17-24(28)26(33-25(31-17)21-13-12-20(27)15-29-21)30-16-22(19-10-6-3-7-11-19)32-23(34)14-18-8-4-2-5-9-18/h2-13,15,22H,14,16H2,1H3,(H,32,34)(H,30,31,33)/t22-/m0/s1
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n/an/an/an/a 700n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433376
PNG
(CHEMBL2375627)
Show SMILES Cc1nc(nc(NC[C@@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Mn2+


J Med Chem 56: 3996-4016 (2013)


Article DOI: 10.1021/jm400227z
BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435187
PNG
(CHEMBL2392929)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2cccs2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H27Cl2N5S/c1-18-24(28)26(33-25(32-18)22-13-12-20(27)16-30-22)31-17-23(19-8-3-2-4-9-19)29-14-6-5-10-21-11-7-15-34-21/h2-4,7-9,11-13,15-16,23,29H,5-6,10,14,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435188
PNG
(CHEMBL2392928)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccco2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H27Cl2N5O/c1-18-24(28)26(33-25(32-18)22-13-12-20(27)16-30-22)31-17-23(19-8-3-2-4-9-19)29-14-6-5-10-21-11-7-15-34-21/h2-4,7-9,11-13,15-16,23,29H,5-6,10,14,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435190
PNG
(CHEMBL2392926)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(cc2)C#N)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H28Cl2N6/c1-20-27(31)29(37-28(36-20)25-15-14-24(30)18-34-25)35-19-26(23-8-3-2-4-9-23)33-16-6-5-7-21-10-12-22(17-32)13-11-21/h2-4,8-15,18,26,33H,5-7,16,19H2,1H3,(H,35,36,37)/t26-/m0/s1
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n/an/an/an/a 1.60E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435191
PNG
(CHEMBL2392925)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(Cl)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H28Cl3N5/c1-19-26(31)28(36-27(35-19)24-15-14-23(30)17-33-24)34-18-25(21-8-3-2-4-9-21)32-16-6-5-7-20-10-12-22(29)13-11-20/h2-4,8-15,17,25,32H,5-7,16,18H2,1H3,(H,34,35,36)/t25-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435192
PNG
(CHEMBL2392924)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(O)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5O/c1-19-26(30)28(35-27(34-19)24-15-12-22(29)17-32-24)33-18-25(21-8-3-2-4-9-21)31-16-6-5-7-20-10-13-23(36)14-11-20/h2-4,8-15,17,25,31,36H,5-7,16,18H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435193
PNG
(CHEMBL2392923)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H33Cl2N5/c1-22-28(32)30(37-29(36-22)26-18-17-25(31)20-34-26)35-21-27(24-15-9-5-10-16-24)33-19-11-3-2-6-12-23-13-7-4-8-14-23/h4-5,7-10,13-18,20,27,33H,2-3,6,11-12,19,21H2,1H3,(H,35,36,37)/t27-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435194
PNG
(CHEMBL2392922)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H31Cl2N5/c1-21-27(31)29(36-28(35-21)25-17-16-24(30)19-33-25)34-20-26(23-14-8-3-9-15-23)32-18-10-4-7-13-22-11-5-2-6-12-22/h2-3,5-6,8-9,11-12,14-17,19,26,32H,4,7,10,13,18,20H2,1H3,(H,34,35,36)/t26-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435195
PNG
(CHEMBL2392921)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435196
PNG
(CHEMBL2392920)
Show SMILES Cc1nc(nc(NC[C@H](NCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H27Cl2N5/c1-19-25(29)27(34-26(33-19)23-15-14-22(28)17-31-23)32-18-24(21-12-6-3-7-13-21)30-16-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-15,17,24,30H,8,11,16,18H2,1H3,(H,32,33,34)/t24-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435197
PNG
(CHEMBL2392919)
Show SMILES Cc1nc(nc(NC[C@H](NCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H25Cl2N5/c1-18-24(28)26(33-25(32-18)22-13-12-21(27)16-30-22)31-17-23(20-10-6-3-7-11-20)29-15-14-19-8-4-2-5-9-19/h2-13,16,23,29H,14-15,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435199
PNG
(CHEMBL2392917)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H31Cl2N5O/c1-21-28(32)30(37-29(35-21)25-18-17-24(31)19-33-25)34-20-26(23-14-8-4-9-15-23)36-27(38)16-10-3-7-13-22-11-5-2-6-12-22/h2,4-6,8-9,11-12,14-15,17-19,26H,3,7,10,13,16,20H2,1H3,(H,36,38)(H,34,35,37)/t26-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435200
PNG
(CHEMBL2392916)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H29Cl2N5O/c1-20-27(31)29(36-28(34-20)24-17-16-23(30)18-32-24)33-19-25(22-13-6-3-7-14-22)35-26(37)15-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-14,16-18,25H,8-9,12,15,19H2,1H3,(H,35,37)(H,33,34,36)/t25-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435202
PNG
(CHEMBL2392914)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H25Cl2N5O/c1-18-25(29)27(34-26(32-18)22-14-13-21(28)16-30-22)31-17-23(20-10-6-3-7-11-20)33-24(35)15-12-19-8-4-2-5-9-19/h2-11,13-14,16,23H,12,15,17H2,1H3,(H,33,35)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435203
PNG
(CHEMBL2390976)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)Cc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c1-17-24(28)26(33-25(31-17)21-13-12-20(27)15-29-21)30-16-22(19-10-6-3-7-11-19)32-23(34)14-18-8-4-2-5-9-18/h2-13,15,22H,14,16H2,1H3,(H,32,34)(H,30,31,33)/t22-/m0/s1
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n/an/an/an/a 2.80E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435187
PNG
(CHEMBL2392929)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2cccs2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H27Cl2N5S/c1-18-24(28)26(33-25(32-18)22-13-12-20(27)16-30-22)31-17-23(19-8-3-2-4-9-19)29-14-6-5-10-21-11-7-15-34-21/h2-4,7-9,11-13,15-16,23,29H,5-6,10,14,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a 380n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435188
PNG
(CHEMBL2392928)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccco2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H27Cl2N5O/c1-18-24(28)26(33-25(32-18)22-13-12-20(27)16-30-22)31-17-23(19-8-3-2-4-9-19)29-14-6-5-10-21-11-7-15-34-21/h2-4,7-9,11-13,15-16,23,29H,5-6,10,14,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a 330n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435190
PNG
(CHEMBL2392926)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(cc2)C#N)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H28Cl2N6/c1-20-27(31)29(37-28(36-20)25-15-14-24(30)18-34-25)35-19-26(23-8-3-2-4-9-23)33-16-6-5-7-21-10-12-22(17-32)13-11-21/h2-4,8-15,18,26,33H,5-7,16,19H2,1H3,(H,35,36,37)/t26-/m0/s1
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n/an/an/an/a 520n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435191
PNG
(CHEMBL2392925)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(Cl)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H28Cl3N5/c1-19-26(31)28(36-27(35-19)24-15-14-23(30)17-33-24)34-18-25(21-8-3-2-4-9-21)32-16-6-5-7-20-10-12-22(29)13-11-20/h2-4,8-15,17,25,32H,5-7,16,18H2,1H3,(H,34,35,36)/t25-/m0/s1
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n/an/an/an/a 570n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435192
PNG
(CHEMBL2392924)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(O)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5O/c1-19-26(30)28(35-27(34-19)24-15-12-22(29)17-32-24)33-18-25(21-8-3-2-4-9-21)31-16-6-5-7-20-10-13-23(36)14-11-20/h2-4,8-15,17,25,31,36H,5-7,16,18H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a 420n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435193
PNG
(CHEMBL2392923)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H33Cl2N5/c1-22-28(32)30(37-29(36-22)26-18-17-25(31)20-34-26)35-21-27(24-15-9-5-10-16-24)33-19-11-3-2-6-12-23-13-7-4-8-14-23/h4-5,7-10,13-18,20,27,33H,2-3,6,11-12,19,21H2,1H3,(H,35,36,37)/t27-/m0/s1
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n/an/an/an/a 710n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435194
PNG
(CHEMBL2392922)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H31Cl2N5/c1-21-27(31)29(36-28(35-21)25-17-16-24(30)19-33-25)34-20-26(23-14-8-3-9-15-23)32-18-10-4-7-13-22-11-5-2-6-12-22/h2-3,5-6,8-9,11-12,14-17,19,26,32H,4,7,10,13,18,20H2,1H3,(H,34,35,36)/t26-/m0/s1
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n/an/an/an/a 780n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435195
PNG
(CHEMBL2392921)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435196
PNG
(CHEMBL2392920)
Show SMILES Cc1nc(nc(NC[C@H](NCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H27Cl2N5/c1-19-25(29)27(34-26(33-19)23-15-14-22(28)17-31-23)32-18-24(21-12-6-3-7-13-21)30-16-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-15,17,24,30H,8,11,16,18H2,1H3,(H,32,33,34)/t24-/m0/s1
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n/an/an/an/a 260n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435197
PNG
(CHEMBL2392919)
Show SMILES Cc1nc(nc(NC[C@H](NCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H25Cl2N5/c1-18-24(28)26(33-25(32-18)22-13-12-21(27)16-30-22)31-17-23(20-10-6-3-7-11-20)29-15-14-19-8-4-2-5-9-19/h2-13,16,23,29H,14-15,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a 260n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435199
PNG
(CHEMBL2392917)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H31Cl2N5O/c1-21-28(32)30(37-29(35-21)25-18-17-24(31)19-33-25)34-20-26(23-14-8-4-9-15-23)36-27(38)16-10-3-7-13-22-11-5-2-6-12-22/h2,4-6,8-9,11-12,14-15,17-19,26H,3,7,10,13,16,20H2,1H3,(H,36,38)(H,34,35,37)/t26-/m0/s1
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n/an/an/an/a 670n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435200
PNG
(CHEMBL2392916)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H29Cl2N5O/c1-20-27(31)29(36-28(34-20)24-17-16-23(30)18-32-24)33-19-25(22-13-6-3-7-14-22)35-26(37)15-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-14,16-18,25H,8-9,12,15,19H2,1H3,(H,35,37)(H,33,34,36)/t25-/m0/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435202
PNG
(CHEMBL2392914)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H25Cl2N5O/c1-18-25(29)27(34-26(32-18)22-14-13-21(28)16-30-22)31-17-23(20-10-6-3-7-11-20)33-24(35)15-12-19-8-4-2-5-9-19/h2-11,13-14,16,23H,12,15,17H2,1H3,(H,33,35)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a 93n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)


Article DOI: 10.1016/j.bmc.2013.02.023
BindingDB Entry DOI: 10.7270/Q290256X
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433376
PNG
(CHEMBL2375627)
Show SMILES Cc1nc(nc(NC[C@@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Zn2+


J Med Chem 56: 3996-4016 (2013)


Article DOI: 10.1021/jm400227z
BindingDB Entry DOI: 10.7270/Q2SJ1N1Z
More data for this
Ligand-Target Pair