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13 similar compounds to monomer 13592

Compile data set for download or QSAR
Wt: 569.6
BDBM50439482
Wt: 553.6
BDBM50439484
Wt: 555.6
BDBM50439485
Wt: 555.6
BDBM50439486
Wt: 541.5
BDBM50439487
Wt: 534.5
BDBM50439470
Wt: 546.5
BDBM50439472
Wt: 527.5
BDBM50439473
Wt: 557.5
BDBM50439474
Wt: 503.5
BDBM50439475
Wt: 504.5
BDBM50439476
Wt: 567.6
BDBM50439480
Wt: 569.6
BDBM50439481

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50439482,50439484,50439485,50439486,50439487,50439470,50439472,50439473,50439474,50439475,50439476,50439480,50439481   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50439470
PNG
(CHEMBL2417910)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C28H30N4O7/c1-28(2,3)21(14-33)31-25(35)16-8-9-18(20(13-16)27(37)38)19-10-11-22(39-4)32-23(19)26(36)30-17-7-5-6-15(12-17)24(29)34/h5-13,21,33H,14H2,1-4H3,(H2,29,34)(H,30,36)(H,31,35)(H,37,38)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439487
PNG
(CHEMBL2417893)
Show SMILES CCOc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C30H31N5O5/c1-5-40-24-11-10-22(21-8-6-18(15-23(21)29(38)39)27(36)33-16-30(2,3)4)25(35-24)28(37)34-19-7-9-20-17(14-19)12-13-32-26(20)31/h6-15H,5,16H2,1-4H3,(H2,31,32)(H,33,36)(H,34,37)(H,38,39)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50439473
PNG
(CHEMBL2417907)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C29H29N5O5/c1-29(2,3)15-32-26(35)17-5-7-20(22(14-17)28(37)38)21-9-10-23(39-4)34-24(21)27(36)33-18-6-8-19-16(13-18)11-12-31-25(19)30/h5-14H,15H2,1-4H3,(H2,30,31)(H,32,35)(H,33,36)(H,37,38)
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50439474
PNG
(CHEMBL2417906)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C30H31N5O6/c1-30(2,3)23(15-36)34-27(37)17-5-7-20(22(14-17)29(39)40)21-9-10-24(41-4)35-25(21)28(38)33-18-6-8-19-16(13-18)11-12-32-26(19)31/h5-14,23,36H,15H2,1-4H3,(H2,31,32)(H,33,38)(H,34,37)(H,39,40)/t23-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50439475
PNG
(CHEMBL2417905)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H29N5O5/c1-27(2,3)14-30-24(33)16-7-10-18(20(13-16)26(35)36)19-11-12-21(37-4)32-22(19)25(34)31-17-8-5-15(6-9-17)23(28)29/h5-13H,14H2,1-4H3,(H3,28,29)(H,30,33)(H,31,34)(H,35,36)
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50439470
PNG
(CHEMBL2417910)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C28H30N4O7/c1-28(2,3)21(14-33)31-25(35)16-8-9-18(20(13-16)27(37)38)19-10-11-22(39-4)32-23(19)26(36)30-17-7-5-6-15(12-17)24(29)34/h5-13,21,33H,14H2,1-4H3,(H2,29,34)(H,30,36)(H,31,35)(H,37,38)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50439472
PNG
(CHEMBL2417908)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1
Show InChI InChI=1S/C28H30N6O6/c1-28(2,3)21(13-35)33-24(36)14-5-7-16(18(11-14)26(38)39)17-8-10-22(40-4)34-23(17)25(37)30-15-6-9-19-20(12-15)32-27(29)31-19/h5-12,21,35H,13H2,1-4H3,(H,30,37)(H,33,36)(H,38,39)(H3,29,31,32)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50439473
PNG
(CHEMBL2417907)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C29H29N5O5/c1-29(2,3)15-32-26(35)17-5-7-20(22(14-17)28(37)38)21-9-10-23(39-4)34-24(21)27(36)33-18-6-8-19-16(13-18)11-12-31-25(19)30/h5-14H,15H2,1-4H3,(H2,30,31)(H,32,35)(H,33,36)(H,37,38)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50439474
PNG
(CHEMBL2417906)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C30H31N5O6/c1-30(2,3)23(15-36)34-27(37)17-5-7-20(22(14-17)29(39)40)21-9-10-24(41-4)35-25(21)28(38)33-18-6-8-19-16(13-18)11-12-32-26(19)31/h5-14,23,36H,15H2,1-4H3,(H2,31,32)(H,33,38)(H,34,37)(H,39,40)/t23-/m1/s1
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n/an/a 1.09E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50439475
PNG
(CHEMBL2417905)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H29N5O5/c1-27(2,3)14-30-24(33)16-7-10-18(20(13-16)26(35)36)19-11-12-21(37-4)32-22(19)25(34)31-17-8-5-15(6-9-17)23(28)29/h5-13H,14H2,1-4H3,(H3,28,29)(H,30,33)(H,31,34)(H,35,36)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50439470
PNG
(CHEMBL2417910)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C28H30N4O7/c1-28(2,3)21(14-33)31-25(35)16-8-9-18(20(13-16)27(37)38)19-10-11-22(39-4)32-23(19)26(36)30-17-7-5-6-15(12-17)24(29)34/h5-13,21,33H,14H2,1-4H3,(H2,29,34)(H,30,36)(H,31,35)(H,37,38)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50439472
PNG
(CHEMBL2417908)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1
Show InChI InChI=1S/C28H30N6O6/c1-28(2,3)21(13-35)33-24(36)14-5-7-16(18(11-14)26(38)39)17-8-10-22(40-4)34-23(17)25(37)30-15-6-9-19-20(12-15)32-27(29)31-19/h5-12,21,35H,13H2,1-4H3,(H,30,37)(H,33,36)(H,38,39)(H3,29,31,32)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50439473
PNG
(CHEMBL2417907)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C29H29N5O5/c1-29(2,3)15-32-26(35)17-5-7-20(22(14-17)28(37)38)21-9-10-23(39-4)34-24(21)27(36)33-18-6-8-19-16(13-18)11-12-31-25(19)30/h5-14H,15H2,1-4H3,(H2,30,31)(H,32,35)(H,33,36)(H,37,38)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50439474
PNG
(CHEMBL2417906)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C30H31N5O6/c1-30(2,3)23(15-36)34-27(37)17-5-7-20(22(14-17)29(39)40)21-9-10-24(41-4)35-25(21)28(38)33-18-6-8-19-16(13-18)11-12-32-26(19)31/h5-14,23,36H,15H2,1-4H3,(H2,31,32)(H,33,38)(H,34,37)(H,39,40)/t23-/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50439475
PNG
(CHEMBL2417905)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H29N5O5/c1-27(2,3)14-30-24(33)16-7-10-18(20(13-16)26(35)36)19-11-12-21(37-4)32-22(19)25(34)31-17-8-5-15(6-9-17)23(28)29/h5-13H,14H2,1-4H3,(H3,28,29)(H,30,33)(H,31,34)(H,35,36)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439476
PNG
(CHEMBL2417892)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C27H28N4O6/c1-27(2,3)14-29-24(33)16-8-9-18(20(13-16)26(35)36)19-10-11-21(37-4)31-22(19)25(34)30-17-7-5-6-15(12-17)23(28)32/h5-13H,14H2,1-4H3,(H2,28,32)(H,29,33)(H,30,34)(H,35,36)
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n/an/a 265n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439470
PNG
(CHEMBL2417910)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C28H30N4O7/c1-28(2,3)21(14-33)31-25(35)16-8-9-18(20(13-16)27(37)38)19-10-11-22(39-4)32-23(19)26(36)30-17-7-5-6-15(12-17)24(29)34/h5-13,21,33H,14H2,1-4H3,(H2,29,34)(H,30,36)(H,31,35)(H,37,38)/t21-/m1/s1
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n/an/a 175n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439472
PNG
(CHEMBL2417908)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1
Show InChI InChI=1S/C28H30N6O6/c1-28(2,3)21(13-35)33-24(36)14-5-7-16(18(11-14)26(38)39)17-8-10-22(40-4)34-23(17)25(37)30-15-6-9-19-20(12-15)32-27(29)31-19/h5-12,21,35H,13H2,1-4H3,(H,30,37)(H,33,36)(H,38,39)(H3,29,31,32)/t21-/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439473
PNG
(CHEMBL2417907)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C29H29N5O5/c1-29(2,3)15-32-26(35)17-5-7-20(22(14-17)28(37)38)21-9-10-23(39-4)34-24(21)27(36)33-18-6-8-19-16(13-18)11-12-31-25(19)30/h5-14H,15H2,1-4H3,(H2,30,31)(H,32,35)(H,33,36)(H,37,38)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439474
PNG
(CHEMBL2417906)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C30H31N5O6/c1-30(2,3)23(15-36)34-27(37)17-5-7-20(22(14-17)29(39)40)21-9-10-24(41-4)35-25(21)28(38)33-18-6-8-19-16(13-18)11-12-32-26(19)31/h5-14,23,36H,15H2,1-4H3,(H2,31,32)(H,33,38)(H,34,37)(H,39,40)/t23-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439475
PNG
(CHEMBL2417905)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H29N5O5/c1-27(2,3)14-30-24(33)16-7-10-18(20(13-16)26(35)36)19-11-12-21(37-4)32-22(19)25(34)31-17-8-5-15(6-9-17)23(28)29/h5-13H,14H2,1-4H3,(H3,28,29)(H,30,33)(H,31,34)(H,35,36)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439480
PNG
(CHEMBL2417900)
Show SMILES CC(C)(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(OC2CCC2)nc1C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C32H33N5O5/c1-32(2,3)17-35-29(38)19-7-9-23(25(16-19)31(40)41)24-11-12-26(42-21-5-4-6-21)37-27(24)30(39)36-20-8-10-22-18(15-20)13-14-34-28(22)33/h7-16,21H,4-6,17H2,1-3H3,(H2,33,34)(H,35,38)(H,36,39)(H,40,41)
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n/an/a 499n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439481
PNG
(CHEMBL2417899)
Show SMILES CCCCOc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C32H35N5O5/c1-5-6-15-42-26-12-11-24(23-9-7-20(17-25(23)31(40)41)29(38)35-18-32(2,3)4)27(37-26)30(39)36-21-8-10-22-19(16-21)13-14-34-28(22)33/h7-14,16-17H,5-6,15,18H2,1-4H3,(H2,33,34)(H,35,38)(H,36,39)(H,40,41)
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n/an/a 357n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439482
PNG
(CHEMBL2417898)
Show SMILES CC(C)COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C32H35N5O5/c1-18(2)16-42-26-11-10-24(23-8-6-20(15-25(23)31(40)41)29(38)35-17-32(3,4)5)27(37-26)30(39)36-21-7-9-22-19(14-21)12-13-34-28(22)33/h6-15,18H,16-17H2,1-5H3,(H2,33,34)(H,35,38)(H,36,39)(H,40,41)
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n/an/a 437n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439484
PNG
(CHEMBL2417896)
Show SMILES CC(C)(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(OCC=C)nc1C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C31H31N5O5/c1-5-14-41-25-11-10-23(22-8-6-19(16-24(22)30(39)40)28(37)34-17-31(2,3)4)26(36-25)29(38)35-20-7-9-21-18(15-20)12-13-33-27(21)32/h5-13,15-16H,1,14,17H2,2-4H3,(H2,32,33)(H,34,37)(H,35,38)(H,39,40)
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n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439485
PNG
(CHEMBL2417895)
Show SMILES CC(C)Oc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C31H33N5O5/c1-17(2)41-25-11-10-23(22-8-6-19(15-24(22)30(39)40)28(37)34-16-31(3,4)5)26(36-25)29(38)35-20-7-9-21-18(14-20)12-13-33-27(21)32/h6-15,17H,16H2,1-5H3,(H2,32,33)(H,34,37)(H,35,38)(H,39,40)
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n/an/a 111n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50439486
PNG
(CHEMBL2417894)
Show SMILES CCCOc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2c(N)nccc2c1
Show InChI InChI=1S/C31H33N5O5/c1-5-14-41-25-11-10-23(22-8-6-19(16-24(22)30(39)40)28(37)34-17-31(2,3)4)26(36-25)29(38)35-20-7-9-21-18(15-20)12-13-33-27(21)32/h6-13,15-16H,5,14,17H2,1-4H3,(H2,32,33)(H,34,37)(H,35,38)(H,39,40)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50439472
PNG
(CHEMBL2417908)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1
Show InChI InChI=1S/C28H30N6O6/c1-28(2,3)21(13-35)33-24(36)14-5-7-16(18(11-14)26(38)39)17-8-10-22(40-4)34-23(17)25(37)30-15-6-9-19-20(12-15)32-27(29)31-19/h5-12,21,35H,13H2,1-4H3,(H,30,37)(H,33,36)(H,38,39)(H3,29,31,32)/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins


Bioorg Med Chem Lett 23: 5239-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C
More data for this
Ligand-Target Pair