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6 similar compounds to monomer 50443754

Compile data set for download or QSAR
Wt: 275.3
BDBM50443760
Wt: 317.4
BDBM50443731
Wt: 329.2
BDBM50443732
Wt: 286.3
BDBM50443733
Wt: 367.4
BDBM50443749
Wt: 261.2
BDBM50443753

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50443760,50443731,50443732,50443733,50443749,50443753   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443731
PNG
(CHEMBL3093909)
Show SMILES CC(C)(C)c1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C18H24FN3O/c1-18(2,3)13-6-4-12(5-7-13)8-16(21)17(23)22-11-14(19)9-15(22)10-20/h4-7,14-16H,8-9,11,21H2,1-3H3/t14-,15-,16-/m0/s1
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PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443760
PNG
(CHEMBL3093904)
Show SMILES Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C15H18FN3O/c1-10-2-4-11(5-3-10)6-14(18)15(20)19-9-12(16)7-13(19)8-17/h2-5,12-14H,6-7,9,18H2,1H3/t12-,13-,14-/m0/s1
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n/an/a 2.55E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443731
PNG
(CHEMBL3093909)
Show SMILES CC(C)(C)c1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C18H24FN3O/c1-18(2,3)13-6-4-12(5-7-13)8-16(21)17(23)22-11-14(19)9-15(22)10-20/h4-7,14-16H,8-9,11,21H2,1-3H3/t14-,15-,16-/m0/s1
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n/an/a 7.19E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443732
PNG
(CHEMBL3093908)
Show SMILES N[C@@H](Cc1ccc(cc1)C(F)(F)F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15F4N3O/c16-11-6-12(7-20)22(8-11)14(23)13(21)5-9-1-3-10(4-2-9)15(17,18)19/h1-4,11-13H,5-6,8,21H2/t11-,12-,13-/m0/s1
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n/an/a 610n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443732
PNG
(CHEMBL3093908)
Show SMILES N[C@@H](Cc1ccc(cc1)C(F)(F)F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15F4N3O/c16-11-6-12(7-20)22(8-11)14(23)13(21)5-9-1-3-10(4-2-9)15(17,18)19/h1-4,11-13H,5-6,8,21H2/t11-,12-,13-/m0/s1
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n/an/a 2.49E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443732
PNG
(CHEMBL3093908)
Show SMILES N[C@@H](Cc1ccc(cc1)C(F)(F)F)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15F4N3O/c16-11-6-12(7-20)22(8-11)14(23)13(21)5-9-1-3-10(4-2-9)15(17,18)19/h1-4,11-13H,5-6,8,21H2/t11-,12-,13-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443733
PNG
(CHEMBL3093907)
Show SMILES N[C@@H](Cc1ccc(cc1)C#N)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15FN4O/c16-12-6-13(8-18)20(9-12)15(21)14(19)5-10-1-3-11(7-17)4-2-10/h1-4,12-14H,5-6,9,19H2/t12-,13-,14-/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443733
PNG
(CHEMBL3093907)
Show SMILES N[C@@H](Cc1ccc(cc1)C#N)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15FN4O/c16-12-6-13(8-18)20(9-12)15(21)14(19)5-10-1-3-11(7-17)4-2-10/h1-4,12-14H,5-6,9,19H2/t12-,13-,14-/m0/s1
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n/an/a 1.29E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443733
PNG
(CHEMBL3093907)
Show SMILES N[C@@H](Cc1ccc(cc1)C#N)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C15H15FN4O/c16-12-6-13(8-18)20(9-12)15(21)14(19)5-10-1-3-11(7-17)4-2-10/h1-4,12-14H,5-6,9,19H2/t12-,13-,14-/m0/s1
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n/an/a 3.11E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443749
PNG
(CHEMBL3093910)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C21H22FN3O2/c22-17-11-18(12-23)25(13-17)21(26)20(24)10-15-6-8-19(9-7-15)27-14-16-4-2-1-3-5-16/h1-9,17-18,20H,10-11,13-14,24H2/t17-,18-,20-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443749
PNG
(CHEMBL3093910)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C21H22FN3O2/c22-17-11-18(12-23)25(13-17)21(26)20(24)10-15-6-8-19(9-7-15)27-14-16-4-2-1-3-5-16/h1-9,17-18,20H,10-11,13-14,24H2/t17-,18-,20-/m0/s1
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n/an/a 7.74E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443749
PNG
(CHEMBL3093910)
Show SMILES N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C21H22FN3O2/c22-17-11-18(12-23)25(13-17)21(26)20(24)10-15-6-8-19(9-7-15)27-14-16-4-2-1-3-5-16/h1-9,17-18,20H,10-11,13-14,24H2/t17-,18-,20-/m0/s1
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n/an/a 3.42E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 1.53E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 1.98E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50443753
PNG
(CHEMBL3093902)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1C[C@@H](F)C[C@H]1C#N
Show InChI InChI=1S/C14H16FN3O/c15-11-7-12(8-16)18(9-11)14(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-13H,6-7,9,17H2/t11-,12-,13-/m0/s1
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n/an/a 2.25E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP8 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50443760
PNG
(CHEMBL3093904)
Show SMILES Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C15H18FN3O/c1-10-2-4-11(5-3-10)6-14(18)15(20)19-9-12(16)7-13(19)8-17/h2-5,12-14H,6-7,9,18H2,1H3/t12-,13-,14-/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant FAP (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Nle-Pro-aminomethylc...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443760
PNG
(CHEMBL3093904)
Show SMILES Cc1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C15H18FN3O/c1-10-2-4-11(5-3-10)6-14(18)15(20)19-9-12(16)7-13(19)8-17/h2-5,12-14H,6-7,9,18H2,1H3/t12-,13-,14-/m0/s1
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n/an/a 1.76E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50443731
PNG
(CHEMBL3093909)
Show SMILES CC(C)(C)c1ccc(C[C@H](N)C(=O)N2C[C@@H](F)C[C@H]2C#N)cc1
Show InChI InChI=1S/C18H24FN3O/c1-18(2,3)13-6-4-12(5-7-13)8-16(21)17(23)22-11-14(19)9-15(22)10-20/h4-7,14-16H,8-9,11,21H2,1-3H3/t14-,15-,16-/m0/s1
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n/an/a 9.19E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged recombinant DPP9 (unknown origin) expressed in baculovirus expression system assessed as hydrolysis of Ala-Pro-aminomethyl...


Bioorg Med Chem 21: 7418-29 (2013)


Article DOI: 10.1016/j.bmc.2013.09.048
BindingDB Entry DOI: 10.7270/Q2WS8VPZ
More data for this
Ligand-Target Pair