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46 similar compounds to monomer 60483

Compile data set for download or QSAR
Wt: 390.2
BDBM50482
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Wt: 339.4
BDBM50957
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Wt: 345.8
BDBM53933
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Wt: 339.4
BDBM66112
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Wt: 325.3
BDBM80698
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Wt: 345.8
BDBM50297556
Wt: 323.4
BDBM50297557
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Wt: 310.3
BDBM50341251
Wt: 309.3
BDBM50341252
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Wt: 345.8
BDBM50341254
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Wt: 311.3
BDBM50341255
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Wt: 309.3
BDBM50341258
Wt: 339.4
BDBM50341259
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Wt: 369.4
BDBM50341260
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Wt: 339.4
BDBM50341261
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Displayed 1 to 15 (of 46 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50482,50957,53933,66112,80698,50297556,50297557,50341251,50341252,50341254,50341255,50341258,50341259,50341260,50341261   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BZLF2


(Human herpesvirus 4 type 2)
BDBM50957
PNG
((5Z)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11-
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n/an/a 2.21E+3n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2057DCW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50482
PNG
((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...)
Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cc(O)c(O)c(Br)c1
Show InChI InChI=1S/C17H12BrNO3S/c1-9-2-4-11(5-3-9)17-19-16(22)14(23-17)8-10-6-12(18)15(21)13(20)7-10/h2-8,20-21H,1H3/b14-8-
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n/an/a 120n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 25 m...


Bioorg Med Chem Lett 27: 1776-1779 (2017)

More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM53933
PNG
((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(Cl)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-8-10(7-12(18)15(13)20)9-14-16(21)19-17(23-14)11-5-3-2-4-6-11/h2-9,20H,1H3/b14-9-
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n/an/a 2.00E+4n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27H1H0J
More data for this
Ligand-Target Pair
large T antigen


(Simian virus 40)
BDBM50482
PNG
((5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-to...)
Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cc(O)c(O)c(Br)c1
Show InChI InChI=1S/C17H12BrNO3S/c1-9-2-4-11(5-3-9)17-19-16(22)14(23-17)8-10-6-12(18)15(21)13(20)7-10/h2-8,20-21H,1H3/b14-8-
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n/an/an/an/a>5.00E+4n/an/an/an/a



Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay


Assay Description
Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2ZK5F47
More data for this
Ligand-Target Pair
Beta lactamase


(Pseudomonas aeruginosa)
BDBM66112
PNG
((5E)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2\SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11+
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n/an/a>5.96E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2S75DSB
More data for this
Ligand-Target Pair
beta-lactamase


(Salmonella enterica subsp. enterica serovar Choler...)
BDBM66112
PNG
((5E)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2\SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11+
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n/an/a>5.96E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2NG4P3G
More data for this
Ligand-Target Pair
metallo-beta-lactamase IMP-1


(Pseudomonas aeruginosa)
BDBM66112
PNG
((5E)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2\SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11+
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n/an/a>5.96E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2HT2MRM
More data for this
Ligand-Target Pair
putative hexokinase HKDC1


(Homo sapiens (Human))
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a 3.83E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2W094D4
More data for this
Ligand-Target Pair
cardiac alpha tropomyosin


(Sus scrofa)
BDBM66112
PNG
((5E)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2\SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11+
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n/an/an/an/a 742n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q21N7ZKB
More data for this
Ligand-Target Pair
Glucose 6-phosphate dehydrogenase (G6PD)


(Homo sapiens (Human))
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2V12389
More data for this
Ligand-Target Pair
putative hexokinase HKDC1


(Homo sapiens (Human))
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a 8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q23F4N3R
More data for this
Ligand-Target Pair
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase


(Plasmodium falciparum 3D7)
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a 8.70E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2ZS2TZG
More data for this
Ligand-Target Pair
mRNA interferase toxin, antitoxin is MazE


(Escherichia coli str. K-12 substr. MG1655)
BDBM50957
PNG
((5Z)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11-
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n/an/an/an/a>9.90E+4n/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2Z31X54
More data for this
Ligand-Target Pair
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase


(Plasmodium falciparum 3D7)
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q27H1H3W
More data for this
Ligand-Target Pair
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase


(Plasmodium falciparum 3D7)
BDBM80698
PNG
((5Z)-2-(p-tolyl)-5-vanillylidene-2-thiazolin-4-one...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C18H15NO3S/c1-11-3-6-13(7-4-11)18-19-17(21)16(23-18)10-12-5-8-14(20)15(9-12)22-2/h3-10,20H,1-2H3/b16-10-
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q23T9FQ1
More data for this
Ligand-Target Pair
mRNA interferase toxin, antitoxin is MazE


(Escherichia coli str. K-12 substr. MG1655)
BDBM50957
PNG
((5Z)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11-
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n/an/an/an/a>9.90E+4n/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2TB15DB
More data for this
Ligand-Target Pair
Candida albicans strain ATCC 10261 multidrug efflux pump (MDR1) gene, MDR1-A allele, complete cds


(Candida albicans)
BDBM50957
PNG
((5Z)-2-(p-tolyl)-5-veratrylidene-2-thiazolin-4-one...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C19H17NO3S/c1-12-4-7-14(8-5-12)19-20-18(21)17(24-19)11-13-6-9-15(22-2)16(10-13)23-3/h4-11H,1-3H3/b17-11-
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n/an/an/an/a 5.12E+3n/an/an/an/a



NMMLSC

Curated by PubChem BioAssay


Assay Description
UNMCMD Assay Overview: Assay Support: 1 R03 MH087406-01A1 Project Title: Identification of broad-spectrum antifungal efflux pump inhibitors ...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q20V8B9F
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341258
PNG
((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-
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n/an/a 300n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL S100 extract using arachidonic acid as substrate incubated for 15 mins prior to substrate addition measured after 10...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341258
PNG
((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-
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n/an/a 660n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL using arachidonic acid as substrate assessed as product formation incubated for 15 mins prior to substrate addition ...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Enoyl-ACP Reductase (InhA)


(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
BDBM50297556
PNG
((E)-5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-...)
Show SMILES COc1cc(Cl)cc(\C=C2\SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8+
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n/an/a 1.05E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis InhA


Eur J Med Chem 44: 3718-30 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.043
BindingDB Entry DOI: 10.7270/Q2NP24G3
More data for this
Ligand-Target Pair
Enoyl-ACP Reductase (InhA)


(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
BDBM50297557
PNG
(5-(4-ethoxy-3-methylbenzylidene)-2-phenylthiazol-4...)
Show SMILES CCOc1ccc(\C=C2\SC(=NC2=O)c2ccccc2)cc1C
Show InChI InChI=1S/C19H17NO2S/c1-3-22-16-10-9-14(11-13(16)2)12-17-18(21)20-19(23-17)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3/b17-12+
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n/an/a 1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis InhA


Eur J Med Chem 44: 3718-30 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.043
BindingDB Entry DOI: 10.7270/Q2NP24G3
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341251
PNG
((Z)-2-(4-Aminophenyl)-5-(4-methoxybenzylidene)-5H-...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,18H2,1H3/b15-10-
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n/an/a 630n/an/an/an/an/an/a



ZAFES/LiFF/OSF Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation ...


Bioorg Med Chem 20: 3575-83 (2012)


Article DOI: 10.1016/j.bmc.2012.04.003
BindingDB Entry DOI: 10.7270/Q2HD7WPS
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341251
PNG
((Z)-2-(4-Aminophenyl)-5-(4-methoxybenzylidene)-5H-...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,18H2,1H3/b15-10-
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n/an/a 1.93E+3n/an/an/an/an/an/a



ZAFES/LiFF/OSF Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 ...


Bioorg Med Chem 20: 3575-83 (2012)


Article DOI: 10.1016/j.bmc.2012.04.003
BindingDB Entry DOI: 10.7270/Q2HD7WPS
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341251
PNG
((Z)-2-(4-Aminophenyl)-5-(4-methoxybenzylidene)-5H-...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,18H2,1H3/b15-10-
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n/an/a 1.93E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341252
PNG
(5-(4-ethoxybenzylidene)-2-phenyl-5H-thiazol-4-one ...)
Show SMILES CCOc1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-2-21-15-10-8-13(9-11-15)12-16-17(20)19-18(22-16)14-6-4-3-5-7-14/h3-12H,2H2,1H3/b16-12-
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n/an/a 2.00E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341254
PNG
(5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phen...)
Show SMILES COc1cc(Cl)cc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8-
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n/an/a 650n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341255
PNG
(5-(2-hydroxy-3-methoxybenzylidene)-2-phenylthiazol...)
Show SMILES COc1cccc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H13NO3S/c1-21-13-9-5-8-12(15(13)19)10-14-16(20)18-17(22-14)11-6-3-2-4-7-11/h2-10,19H,1H3/b14-10-
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n/an/a 480n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM53933
PNG
((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(Cl)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-8-10(7-12(18)15(13)20)9-14-16(21)19-17(23-14)11-5-3-2-4-6-11/h2-9,20H,1H3/b14-9-
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n/an/a 9.50E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341258
PNG
((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-
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n/an/a 660n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341259
PNG
(5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-
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n/an/a 350n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341260
PNG
(2-p-tolyl-5-(2,3,4-trimethoxybenzylidene)thiazol-4...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1OC
Show InChI InChI=1S/C20H19NO4S/c1-12-5-7-13(8-6-12)20-21-19(22)16(26-20)11-14-9-10-15(23-2)18(25-4)17(14)24-3/h5-11H,1-4H3/b16-11-
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n/an/a 2.45E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341261
PNG
(5-(2,4-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)10-14-8-9-15(22-2)11-16(14)23-3/h4-11H,1-3H3/b17-10-
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n/an/a 2.02E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341252
PNG
(5-(4-ethoxybenzylidene)-2-phenyl-5H-thiazol-4-one ...)
Show SMILES CCOc1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-2-21-15-10-8-13(9-11-15)12-16-17(20)19-18(22-16)14-6-4-3-5-7-14/h3-12H,2H2,1H3/b16-12-
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n/an/a 2.00E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341254
PNG
(5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phen...)
Show SMILES COc1cc(Cl)cc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8-
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n/an/a 650n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341255
PNG
(5-(2-hydroxy-3-methoxybenzylidene)-2-phenylthiazol...)
Show SMILES COc1cccc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H13NO3S/c1-21-13-9-5-8-12(15(13)19)10-14-16(20)18-17(22-14)11-6-3-2-4-7-11/h2-10,19H,1H3/b14-10-
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n/an/a 480n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM53933
PNG
((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(Cl)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-8-10(7-12(18)15(13)20)9-14-16(21)19-17(23-14)11-5-3-2-4-6-11/h2-9,20H,1H3/b14-9-
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n/an/a 9.50E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341258
PNG
((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-
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n/an/a 660n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341259
PNG
(5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-
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n/an/a 350n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341260
PNG
(2-p-tolyl-5-(2,3,4-trimethoxybenzylidene)thiazol-4...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1OC
Show InChI InChI=1S/C20H19NO4S/c1-12-5-7-13(8-6-12)20-21-19(22)16(26-20)11-14-9-10-15(23-2)18(25-4)17(14)24-3/h5-11H,1-4H3/b16-11-
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n/an/a 2.45E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341261
PNG
(5-(2,4-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)10-14-8-9-15(22-2)11-16(14)23-3/h4-11H,1-3H3/b17-10-
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n/an/a 2.02E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341251
PNG
((Z)-2-(4-Aminophenyl)-5-(4-methoxybenzylidene)-5H-...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,18H2,1H3/b15-10-
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n/an/a 1.93E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341252
PNG
(5-(4-ethoxybenzylidene)-2-phenyl-5H-thiazol-4-one ...)
Show SMILES CCOc1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-2-21-15-10-8-13(9-11-15)12-16-17(20)19-18(22-16)14-6-4-3-5-7-14/h3-12H,2H2,1H3/b16-12-
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n/an/a 500n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341254
PNG
(5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phen...)
Show SMILES COc1cc(Cl)cc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8-
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n/an/a 300n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341255
PNG
(5-(2-hydroxy-3-methoxybenzylidene)-2-phenylthiazol...)
Show SMILES COc1cccc(\C=C2/SC(=NC2=O)c2ccccc2)c1O
Show InChI InChI=1S/C17H13NO3S/c1-21-13-9-5-8-12(15(13)19)10-14-16(20)18-17(22-14)11-6-3-2-4-7-11/h2-10,19H,1H3/b14-10-
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n/an/a 540n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM53933
PNG
((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Show SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(Cl)c1O
Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-8-10(7-12(18)15(13)20)9-14-16(21)19-17(23-14)11-5-3-2-4-6-11/h2-9,20H,1H3/b14-9-
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n/an/a 3.00E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341258
PNG
((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-
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n/an/a 300n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341259
PNG
(5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-
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n/an/a 130n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341260
PNG
(2-p-tolyl-5-(2,3,4-trimethoxybenzylidene)thiazol-4...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1OC
Show InChI InChI=1S/C20H19NO4S/c1-12-5-7-13(8-6-12)20-21-19(22)16(26-20)11-14-9-10-15(23-2)18(25-4)17(14)24-3/h5-11H,1-4H3/b16-11-
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n/an/a 400n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341261
PNG
(5-(2,4-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1
Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)10-14-8-9-15(22-2)11-16(14)23-3/h4-11H,1-3H3/b17-10-
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n/an/a 980n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50341251
PNG
((Z)-2-(4-Aminophenyl)-5-(4-methoxybenzylidene)-5H-...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,18H2,1H3/b15-10-
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n/an/a 630n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...


J Med Chem 54: 1943-7 (2011)

Checked by Author
Article DOI: 10.1021/jm101165z
BindingDB Entry DOI: 10.7270/Q23T9J70
More data for this
Ligand-Target Pair
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