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5 similar compounds to monomer 50434748

Compile data set for download or QSAR
Wt: 301.3
BDBM5294
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Wt: 302.3
BDBM5420
Wt: 302.3
BDBM5421
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Wt: 302.3
BDBM5430
Wt: 304.1
BDBM50243367
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 5294,5420,5421,5430,50243367   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5294
PNG
(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3
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Article
PubMed
n/an/a 71n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 14: 909-12 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.007
BindingDB Entry DOI: 10.7270/Q2JQ0Z63
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5420
PNG
(4-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-13(3-5-16)15-10-20-18-17(11-21-22(18)12-15)14-6-8-19-9-7-14/h2-12H,1H3
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Article
PubMed
n/an/a 37n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)


Article DOI: 10.1016/s0960-894x(02)00525-5
BindingDB Entry DOI: 10.7270/Q2NG4NTG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5421
PNG
(3-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccnc1
Show InChI InChI=1S/C18H14N4O/c1-23-16-6-4-13(5-7-16)15-10-20-18-17(11-21-22(18)12-15)14-3-2-8-19-9-14/h2-12H,1H3
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PubMed
n/an/a 41n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)


Article DOI: 10.1016/s0960-894x(02)00525-5
BindingDB Entry DOI: 10.7270/Q2NG4NTG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5294
PNG
(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3
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Article
PubMed
n/an/a 71n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)


Article DOI: 10.1016/s0960-894x(02)00525-5
BindingDB Entry DOI: 10.7270/Q2NG4NTG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5430
PNG
(4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-y...)
Show SMILES COc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1
Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-14(3-5-16)17-11-21-22-12-15(10-20-18(17)22)13-6-8-19-9-7-13/h2-12H,1H3
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n/an/an/an/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)


Article DOI: 10.1016/s0960-894x(02)00525-5
BindingDB Entry DOI: 10.7270/Q2NG4NTG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM5430
PNG
(4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-y...)
Show SMILES COc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1
Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-14(3-5-16)17-11-21-22-12-15(10-20-18(17)22)13-6-8-19-9-7-13/h2-12H,1H3
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n/an/a 37n/an/an/an/an/an/a



University of KwaZulu-Natal

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate


Eur J Med Chem 126: 298-352 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.019
More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5294
PNG
(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.


ACS Chem Biol 5: 245-53 (2010)


Article DOI: 10.1021/cb9002865
BindingDB Entry DOI: 10.7270/Q2JW8C78
More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5294
PNG
(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3
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Article
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n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...


ACS Chem Biol 5: 245-53 (2010)


Article DOI: 10.1021/cb9002865
BindingDB Entry DOI: 10.7270/Q2JW8C78
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50243367
PNG
(3-bromo-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES COc1ccc(cc1)-c1cnc2c(Br)cnn2c1
Show InChI InChI=1S/C13H10BrN3O/c1-18-11-4-2-9(3-5-11)10-6-15-13-12(14)7-16-17(13)8-10/h2-8H,1H3
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n/an/a>1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


J Med Chem 51: 3777-87 (2008)


Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW
More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens (Human))
BDBM5420
PNG
(4-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-13(3-5-16)15-10-20-18-17(11-21-22(18)12-15)14-6-8-19-9-7-14/h2-12H,1H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.052
BindingDB Entry DOI: 10.7270/Q2BR8S0V
More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5294
PNG
(3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...)
Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3
GoogleScholar
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PC cid
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Article
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n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...


ACS Chem Biol 5: 245-53 (2010)


Article DOI: 10.1021/cb9002865
BindingDB Entry DOI: 10.7270/Q2JW8C78
More data for this
Ligand-Target Pair