BindingDB logo
myBDB logout

19 similar compounds to monomer 50428029

Wt: 458.4
BDBM55575
Wt: 485.5
BDBM50427998
Wt: 527.5
BDBM50428030
Wt: 500.4
BDBM50428031
Wt: 541.4
BDBM50428036
Wt: 523.4
BDBM50428037
Wt: 519.9
BDBM50428042
Wt: 507.9
BDBM50428043
Wt: 489.9
BDBM50428044
Wt: 473.4
BDBM50428045
Wt: 485.5
BDBM50428046
Purchase
Wt: 485.5
BDBM50428047
Wt: 473.4
BDBM50428048
Wt: 455.4
BDBM50428049
Wt: 499.5
BDBM50428050
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 55575,50427998,50428030,50428031,50428036,50428037,50428042,50428043,50428044,50428045,50428046,50428047,50428048,50428049,50428050   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
neutrophil cytosolic factor 1


(Homo sapiens)
BDBM55575
PNG
(4-keto-N-(6-methoxy-1,3-benzothiazol-2-yl)-3-(4-me...)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H18N4O4S/c1-31-15-9-7-14(8-10-15)28-23(30)18-6-4-3-5-17(18)21(27-28)22(29)26-24-25-19-12-11-16(32-2)13-20(19)33-24/h3-13H,1-2H3,(H,25,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/a 5.00E+4n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428050
PNG
(CHEMBL2322622)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(C)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O4S/c1-15-7-12-20-21(13-15)36-26(28-20)29-22(32)14-27-24(33)23-18-5-3-4-6-19(18)25(34)31(30-23)16-8-10-17(35-2)11-9-16/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428030
PNG
(CHEMBL2325508)
Show SMILES CCOC(=O)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C27H21N5O5S/c1-2-37-26(36)16-12-13-20-21(14-16)38-27(29-20)30-22(33)15-28-24(34)23-18-10-6-7-11-19(18)25(35)32(31-23)17-8-4-3-5-9-17/h3-14H,2,15H2,1H3,(H,28,34)(H,29,30,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428031
PNG
(CHEMBL2325507)
Show SMILES [O-][N+](=O)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16N6O5S/c31-20(27-24-26-18-11-10-15(30(34)35)12-19(18)36-24)13-25-22(32)21-16-8-4-5-9-17(16)23(33)29(28-21)14-6-2-1-3-7-14/h1-12H,13H2,(H,25,32)(H,26,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 240n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428036
PNG
(CHEMBL2324265)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)c2ccccc2c1=O
Show InChI InChI=1S/C25H15F4N5O3S/c26-14-6-8-15(9-7-14)34-23(37)17-4-2-1-3-16(17)21(33-34)22(36)30-12-20(35)32-24-31-18-10-5-13(25(27,28)29)11-19(18)38-24/h1-11H,12H2,(H,30,36)(H,31,32,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 90n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428037
PNG
(CHEMBL2325513)
Show SMILES FC(F)(F)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H16F3N5O3S/c26-25(27,28)14-10-11-18-19(12-14)37-24(30-18)31-20(34)13-29-22(35)21-16-8-4-5-9-17(16)23(36)33(32-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,29,35)(H,30,31,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428042
PNG
(CHEMBL2324275)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H18ClN5O4S/c1-35-16-9-7-15(8-10-16)31-24(34)18-5-3-2-4-17(18)22(30-31)23(33)27-13-21(32)29-25-28-19-11-6-14(26)12-20(19)36-25/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428043
PNG
(CHEMBL2324274)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H15ClFN5O3S/c25-13-5-10-18-19(11-13)35-24(28-18)29-20(32)12-27-22(33)21-16-3-1-2-4-17(16)23(34)31(30-21)15-8-6-14(26)7-9-15/h1-11H,12H2,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428044
PNG
(CHEMBL2324273)
Show SMILES Clc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16ClN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428045
PNG
(CHEMBL2324272)
Show SMILES Fc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16FN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 470n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428046
PNG
(CHEMBL2324271)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccccc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H19N5O4S/c1-34-16-12-10-15(11-13-16)30-24(33)18-7-3-2-6-17(18)22(29-30)23(32)26-14-21(31)28-25-27-19-8-4-5-9-20(19)35-25/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428047
PNG
(CHEMBL2324270)
Show SMILES COc1ccccc1-n1nc(C(=O)NCC(=O)Nc2nc3ccccc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H19N5O4S/c1-34-19-12-6-5-11-18(19)30-24(33)16-9-3-2-8-15(16)22(29-30)23(32)26-14-21(31)28-25-27-17-10-4-7-13-20(17)35-25/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428048
PNG
(CHEMBL2324269)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccccc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H16FN5O3S/c25-14-9-11-15(12-10-14)30-23(33)17-6-2-1-5-16(17)21(29-30)22(32)26-13-20(31)28-24-27-18-7-3-4-8-19(18)34-24/h1-12H,13H2,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428049
PNG
(CHEMBL2324268)
Show SMILES O=C(CNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12)Nc1nc2ccccc2s1
Show InChI InChI=1S/C24H17N5O3S/c30-20(27-24-26-18-12-6-7-13-19(18)33-24)14-25-22(31)21-16-10-4-5-11-17(16)23(32)29(28-21)15-8-2-1-3-9-15/h1-13H,14H2,(H,25,31)(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.60E+3n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50427998
PNG
(CHEMBL2322630)
Show SMILES COc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H19N5O4S/c1-34-16-11-12-19-20(13-16)35-25(27-19)28-21(31)14-26-23(32)22-17-9-5-6-10-18(17)24(33)30(29-22)15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 210n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)

More data for this
Ligand-Target Pair