BindingDB logo
myBDB logout

21 similar compounds to monomer 12255

Compile data set for download or QSAR
Wt: 472.9
BDBM6210
Wt: 442.8
BDBM6216
Wt: 472.9
BDBM6217
Wt: 527.0
BDBM12263
Wt: 556.0
BDBM12264
Wt: 412.8
BDBM12225
Wt: 442.8
BDBM12228
Wt: 527.0
BDBM12237
Wt: 512.9
BDBM12238
Wt: 527.0
BDBM12240
Wt: 536.9
BDBM12241
Wt: 398.8
BDBM12245
Wt: 428.8
BDBM12246
Wt: 556.0
BDBM12247
Wt: 426.8
BDBM12248
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 6210,6216,6217,12263,12264,12225,12228,12237,12238,12240,12241,12245,12246,12247,12248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6210
PNG
(Benzodioxole deriv. 19 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12247
PNG
(AZD0530 analogue 25 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CN1CCN(CCCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C28H34ClN5O5/c1-33-8-10-34(11-9-33)7-2-12-36-20-15-22-25(24(16-20)39-19-5-13-35-14-6-19)28(31-17-30-22)32-26-21(29)3-4-23-27(26)38-18-37-23/h3-4,15-17,19H,2,5-14,18H2,1H3,(H,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6217
PNG
(Benzodioxole deriv. 26 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2ncnc(Nc3c4OCOc4ccc3Cl)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-12-17-15(11-20(19)31-8-2-5-28-6-9-30-10-7-28)23(26-13-25-17)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6210
PNG
(Benzodioxole deriv. 19 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6216
PNG
(Benzodioxole deriv. 25 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCOCC3)ccc12
Show InChI InChI=1S/C22H23ClN4O4/c23-17-4-5-19-21(31-14-30-19)20(17)26-22-16-3-2-15(12-18(16)24-13-25-22)29-9-1-6-27-7-10-28-11-8-27/h2-5,12-13H,1,6-11,14H2,(H,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.14E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM6217
PNG
(Benzodioxole deriv. 26 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2ncnc(Nc3c4OCOc4ccc3Cl)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-12-17-15(11-20(19)31-8-2-5-28-6-9-30-10-7-28)23(26-13-25-17)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.38E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12225
PNG
(AZD0530 analogue 3 | N-(5-Chloro-1,3-benzodioxol-4...)
Show SMILES CN1CCC(CC1)Oc1cccc2ncnc(Nc3c4OCOc4ccc3Cl)c12
Show InChI InChI=1S/C21H21ClN4O3/c1-26-9-7-13(8-10-26)29-16-4-2-3-15-18(16)21(24-11-23-15)25-19-14(22)5-6-17-20(19)28-12-27-17/h2-6,11,13H,7-10,12H2,1H3,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12228
PNG
(AZD0530 analogue 6 | N-(5-chloro-2H-1,3-benzodioxo...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C22H23ClN4O4/c1-27-7-5-13(6-8-27)31-18-10-14(28-2)9-16-19(18)22(25-11-24-16)26-20-15(23)3-4-17-21(20)30-12-29-17/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12237
PNG
(AZD0530 analogue 15 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H31ClN4O5/c28-20-4-5-22-26(36-17-35-22)25(20)31-27-24-21(29-16-30-27)14-19(34-11-3-10-32-8-1-2-9-32)15-23(24)37-18-6-12-33-13-7-18/h4-5,14-16,18H,1-3,6-13,17H2,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12238
PNG
(AZD0530 analogue 16 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C26H29ClN4O5/c27-19-3-4-21-25(35-16-34-21)24(19)30-26-23-20(28-15-29-26)13-18(33-12-9-31-7-1-2-8-31)14-22(23)36-17-5-10-32-11-6-17/h3-4,13-15,17H,1-2,5-12,16H2,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12240
PNG
(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES CN1CCC(COc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C27H31ClN4O5/c1-32-8-4-17(5-9-32)14-34-19-12-21-24(23(13-19)37-18-6-10-33-11-7-18)27(30-15-29-21)31-25-20(28)2-3-22-26(25)36-16-35-22/h2-3,12-13,15,17-18H,4-11,14,16H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12241
PNG
(AZD0530 analogue 19 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCOc3ccncc3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H25ClN4O6/c28-20-1-2-22-26(37-16-36-22)25(20)32-27-24-21(30-15-31-27)13-19(14-23(24)38-18-5-9-33-10-6-18)35-12-11-34-17-3-7-29-8-4-17/h1-4,7-8,13-15,18H,5-6,9-12,16H2,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12245
PNG
(AZD0530 analogue 23 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cccc(OC3CCNCC3)c12
Show InChI InChI=1S/C20H19ClN4O3/c21-13-4-5-16-19(27-11-26-16)18(13)25-20-17-14(23-10-24-20)2-1-3-15(17)28-12-6-8-22-9-7-12/h1-5,10,12,22H,6-9,11H2,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 55n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12246
PNG
(AZD0530 analogue 24 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES COc1cc(OC2CCNCC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C21H21ClN4O4/c1-27-13-8-15-18(17(9-13)30-12-4-6-23-7-5-12)21(25-10-24-15)26-19-14(22)2-3-16-20(19)29-11-28-16/h2-3,8-10,12,23H,4-7,11H2,1H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.5n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12247
PNG
(AZD0530 analogue 25 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CN1CCN(CCCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C28H34ClN5O5/c1-33-8-10-34(11-9-33)7-2-12-36-20-15-22-25(24(16-20)39-19-5-13-35-14-6-19)28(31-17-30-22)32-26-21(29)3-4-23-27(26)38-18-37-23/h3-4,15-17,19H,2,5-14,18H2,1H3,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12248
PNG
(AZD0530 analogue 26 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CN1CCC(COc2cccc3ncnc(Nc4c5OCOc5ccc4Cl)c23)CC1
Show InChI InChI=1S/C22H23ClN4O3/c1-27-9-7-14(8-10-27)11-28-17-4-2-3-16-19(17)22(25-12-24-16)26-20-15(23)5-6-18-21(20)30-13-29-18/h2-6,12,14H,7-11,13H2,1H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12263
PNG
(AZD0530 analogue 41 | N-(6-chloro-2,3-dihydro-1,4-...)
Show SMILES Clc1ccc2OCCOc2c1Nc1ncnc2cc(OCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H31ClN4O5/c28-20-3-4-22-26(36-14-13-35-22)25(20)31-27-24-21(29-17-30-27)15-19(34-12-9-32-7-1-2-8-32)16-23(24)37-18-5-10-33-11-6-18/h3-4,15-18H,1-2,5-14H2,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12264
PNG
(AZD0530 analogue 42 | N-(6-chloro-2,3-dihydro-1,4-...)
Show SMILES CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5OCCOc45)ncnc3c2)CC1
Show InChI InChI=1S/C28H34ClN5O5/c1-33-6-8-34(9-7-33)10-13-36-20-16-22-25(24(17-20)39-19-4-11-35-12-5-19)28(31-18-30-22)32-26-21(29)2-3-23-27(26)38-15-14-37-23/h2-3,16-19H,4-15H2,1H3,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 65n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12228
PNG
(AZD0530 analogue 6 | N-(5-chloro-2H-1,3-benzodioxo...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C22H23ClN4O4/c1-27-7-5-13(6-8-27)31-18-10-14(28-2)9-16-19(18)22(25-11-24-16)26-20-15(23)3-4-17-21(20)30-12-29-17/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.15E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12237
PNG
(AZD0530 analogue 15 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H31ClN4O5/c28-20-4-5-22-26(36-17-35-22)25(20)31-27-24-21(29-16-30-27)14-19(34-11-3-10-32-8-1-2-9-32)15-23(24)37-18-6-12-33-13-7-18/h4-5,14-16,18H,1-3,6-13,17H2,(H,29,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12238
PNG
(AZD0530 analogue 16 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C26H29ClN4O5/c27-19-3-4-21-25(35-16-34-21)24(19)30-26-23-20(28-15-29-26)13-18(33-12-9-31-7-1-2-8-31)14-22(23)36-17-5-10-32-11-6-17/h3-4,13-15,17H,1-2,5-12,16H2,(H,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12240
PNG
(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES CN1CCC(COc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C27H31ClN4O5/c1-32-8-4-17(5-9-32)14-34-19-12-21-24(23(13-19)37-18-6-10-33-11-7-18)27(30-15-29-21)31-25-20(28)2-3-22-26(25)36-16-35-22/h2-3,12-13,15,17-18H,4-11,14,16H2,1H3,(H,29,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12241
PNG
(AZD0530 analogue 19 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCOc3ccncc3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H25ClN4O6/c28-20-1-2-22-26(37-16-36-22)25(20)32-27-24-21(30-15-31-27)13-19(14-23(24)38-18-5-9-33-10-6-18)35-12-11-34-17-3-7-29-8-4-17/h1-4,7-8,13-15,18H,5-6,9-12,16H2,(H,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12245
PNG
(AZD0530 analogue 23 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cccc(OC3CCNCC3)c12
Show InChI InChI=1S/C20H19ClN4O3/c21-13-4-5-16-19(27-11-26-16)18(13)25-20-17-14(23-10-24-20)2-1-3-15(17)28-12-6-8-22-9-7-12/h1-5,10,12,22H,6-9,11H2,(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.30E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM12246
PNG
(AZD0530 analogue 24 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES COc1cc(OC2CCNCC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C21H21ClN4O4/c1-27-13-8-15-18(17(9-13)30-12-4-6-23-7-5-12)21(25-10-24-15)26-19-14(22)2-3-16-20(19)29-11-28-16/h2-3,8-10,12,23H,4-7,11H2,1H3,(H,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.15E+4n/an/an/an/an/an/a



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6216
PNG
(Benzodioxole deriv. 25 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCOCC3)ccc12
Show InChI InChI=1S/C22H23ClN4O4/c23-17-4-5-19-21(31-14-30-19)20(17)26-22-16-3-2-15(12-18(16)24-13-25-22)29-9-1-6-27-7-10-28-11-8-27/h2-5,12-13H,1,6-11,14H2,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair