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10 similar compounds to monomer 85702

Wt: 352.4
BDBM81521
Wt: 380.4
BDBM85082
Wt: 320.4
BDBM85684
Purchase
Wt: 336.4
BDBM85689
Wt: 352.4
BDBM85696
Purchase
Wt: 364.4
BDBM85697
Wt: 336.4
BDBM50013889
Purchase
Wt: 320.4
BDBM50024447
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Wt: 320.4
BDBM50027525
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Wt: 322.4
BDBM50147556

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 81521,85082,85684,85689,85696,85697,50013889,50024447,50027525,50147556   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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PubMed
0.120n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor


J Med Chem 36: 3982-4 (1994)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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0.120n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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0.120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes


Bioorg Med Chem Lett 4: 2077-2082 (1994)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM85696
PNG
(LTB4-20-hydroxy)
Show SMILES OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1
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0.540n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to human neutrophil expressing LTB4 receptor


J Med Chem 36: 3982-4 (1994)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil


Bioorg Med Chem Lett 4: 2077-2082 (1994)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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2n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4R


J Nat Prod 56: 441-455 (1993)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM81521
PNG
(20-OH-LTB4 | CAS_1589 | NSC_1589)
Show SMILES OCCCCCC=CCC(O)C=CC=CC=CC(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)
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7.60n/an/an/an/an/an/an/an/a



The University of Tokyo

Curated by PDSP Ki Database




Nature 387: 620-4 (1997)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM81521
PNG
(20-OH-LTB4 | CAS_1589 | NSC_1589)
Show SMILES OCCCCCC=CCC(O)C=CC=CC=CC(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)
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13n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM85697
PNG
(LTB4-20-carboxy)
Show SMILES O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCCC=O
Show InChI InChI=1S/C21H32O5/c22-18-11-7-3-1-2-4-8-13-19(23)14-9-5-6-10-15-20(24)16-12-17-21(25)26/h4-6,8-10,14-15,18-20,23-24H,1-3,7,11-13,16-17H2,(H,25,26)/b6-5+,8-4-,14-9+,15-10-/t19-,20-/m1/s1
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20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM85696
PNG
(LTB4-20-hydroxy)
Show SMILES OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1
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41n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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93n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM85082
PNG
(20-COOH-LTB4 | CAS_128572 | NSC_128572)
Show SMILES OC(CCCC(O)=O)C=CC=CC=CC(O)CC=CCCCCCC(O)=O
Show InChI InChI=1S/C21H32O6/c22-18(12-7-3-1-2-4-10-16-20(24)25)13-8-5-6-9-14-19(23)15-11-17-21(26)27/h3,5-9,13-14,18-19,22-23H,1-2,4,10-12,15-17H2,(H,24,25)(H,26,27)
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190n/an/an/an/an/an/an/an/a



The University of Tokyo

Curated by PDSP Ki Database




Nature 387: 620-4 (1997)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM85689
PNG
(LTB4-6-trans)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19-/m1/s1
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336n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM81521
PNG
(20-OH-LTB4 | CAS_1589 | NSC_1589)
Show SMILES OCCCCCC=CCC(O)C=CC=CC=CC(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)
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427n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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454n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM85689
PNG
(LTB4-6-trans)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C\[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM85697
PNG
(LTB4-20-carboxy)
Show SMILES O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCCC=O
Show InChI InChI=1S/C21H32O5/c22-18-11-7-3-1-2-4-8-13-19(23)14-9-5-6-10-15-20(24)16-12-17-21(25)26/h4-6,8-10,14-15,18-20,23-24H,1-3,7,11-13,16-17H2,(H,25,26)/b6-5+,8-4-,14-9+,15-10-/t19-,20-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM85684
PNG
(CAS_5283163 | HETE-8(R ) | NSC_5283163)
Show SMILES CCCCCC=CCC=CC=CC(O)CC=CCCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)
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1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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3.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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>1.00E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM85684
PNG
(CAS_5283163 | HETE-8(R ) | NSC_5283163)
Show SMILES CCCCCC=CCC=CC=CC(O)CC=CCCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by PDSP Ki Database




J Biol Chem 275: 40686-94 (2000)

More data for this
Ligand-Target Pair
Leukotriene 2


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Virginia

Curated by PDSP Ki Database




J Biol Chem 275: 30531-6 (2000)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils


Citation and Details
More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against leukotriene B4 receptor


Bioorg Med Chem Lett 4: 811-816 (1994)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [3H]-LTB4 to Leukotriene B4 receptor in human neutrophils


J Med Chem 33: 2807-13 (1990)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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n/an/a 7.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase


J Med Chem 30: 254-63 (1987)

More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50147556
PNG
((6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxy-nonadeca-6...)
Show SMILES CCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C19H30O4/c1-2-3-4-5-8-12-17(20)13-9-6-7-10-14-18(21)15-11-16-19(22)23/h5-10,13-14,17-18,20-21H,2-4,11-12,15-16H2,1H3,(H,22,23)/b7-6+,8-5-,13-9+,14-10-/t17-,18-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Concentration required against dynamin-1 GTPase activity of sheep brain; increased dynamin I GTPase activity at 30 uM.


Bioorg Med Chem Lett 14: 3275-8 (2004)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50027525
PNG
((5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetrae...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase


J Med Chem 26: 72-8 (1983)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50024447
PNG
((6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraeno...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(O)CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
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n/an/a 7.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.


J Med Chem 30: 1177-86 (1987)

More data for this
Ligand-Target Pair