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96 similar compounds to monomer 50008377

Compile data set for download or QSAR
Wt: 1021.1
BDBM50008382
Wt: 1334.5
BDBM81943
Wt: 943.1
BDBM50001597
Wt: 3300.8
BDBM50004964
Wt: 3002.4
BDBM50004965
Wt: 3357.8
BDBM50004966
Purchase
Wt: 3499.0
BDBM50004968
Wt: 3270.8
BDBM50004970
Wt: 3243.7
BDBM50004971
Wt: 3471.0
BDBM50004973
Wt: 3399.9
BDBM50004974
Wt: 3229.7
BDBM50004975
Wt: 3442.9
BDBM50004978
Wt: 3358.8
BDBM50004979
Wt: 3229.7
BDBM50004980
Displayed 1 to 15 (of 96 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50008382,81943,50001597,50004964,50004965,50004966,50004968,50004970,50004971,50004973,50004974,50004975,50004978,50004979,50004980   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BHE


(MOUSE)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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0.5n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
BHE


(RAT)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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1.90n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
BHE


(GUINEA PIG)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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2.60n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
BHE


(RAT)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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4.10n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
Substance K


(RAT)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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6n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
Substance K


(MOUSE)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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7n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
Substance P


(GUINEA PIG)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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9n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
Substance K


(RAT)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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9n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
Neurokinin 2 receptor


(GUINEA PIG)
BDBM81943
PNG
(CAS_45749 | NSC_45749 | kassinin)
Show SMILES CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CC(O)=O)C(C)C)C(C)C)C(N)=O
Show InChI InChI=1S/C59H95N15O18S/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81)
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11n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 236: 819-31 (1986)


BindingDB Entry DOI: 10.7270/Q2D50KFX
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50008382
PNG
(Ac-Phe-Lys-AspMet-GIn-Leu-Gly-Arg-OH | CHEMBL23706...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccccc1)C(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C45H72N12O13S/c1-25(2)21-33(39(64)51-24-36(60)52-32(44(69)70)14-10-19-50-45(48)49)56-41(66)30(15-16-35(47)59)54-42(67)31(17-20-71-4)55-43(68)34(23-37(61)62)57-40(65)29(13-8-9-18-46)53-38(63)28(26(3)58)22-27-11-6-5-7-12-27/h5-7,11-12,25,28-34H,8-10,13-24,46H2,1-4H3,(H2,47,59)(H,51,64)(H,52,60)(H,53,63)(H,54,67)(H,55,68)(H,56,66)(H,57,65)(H,61,62)(H,69,70)(H4,48,49,50)/t28-,29-,30-,31-,32-,33-,34-/m0/s1
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PubMed
200n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against [125I]-rC5a binding to C5a anaphylatoxin chemotactic receptor in human polymorphonuclear leukocyte (PMNL) membranes


J Med Chem 35: 402-6 (1992)


Article DOI: 10.1021/jm00080a030
BindingDB Entry DOI: 10.7270/Q2HH6J1S
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004979
PNG
(CHEMBL440262 | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C149H245N43O43S/c1-20-77(13)116(190-121(209)81(17)167-131(219)104(66-113(203)204)177-120(208)79(15)166-122(210)88(152)62-84-39-43-86(197)44-40-84)144(232)184-102(63-83-32-23-22-24-33-83)137(225)192-118(82(18)196)145(233)185-103(65-111(155)201)136(224)188-108(71-195)141(229)181-101(64-85-41-45-87(198)46-42-85)135(223)173-92(37-30-55-163-148(158)159)125(213)172-90(35-26-28-53-151)130(218)189-115(76(11)12)142(230)183-97(58-72(3)4)123(211)165-68-112(202)169-93(47-49-109(153)199)127(215)179-100(61-75(9)10)134(222)187-106(69-193)139(227)168-80(16)119(207)170-91(36-29-54-162-147(156)157)124(212)171-89(34-25-27-52-150)126(214)178-99(60-74(7)8)133(221)180-98(59-73(5)6)132(220)174-94(48-50-110(154)200)128(216)182-105(67-114(205)206)138(226)191-117(78(14)21-2)143(231)175-95(51-57-236-19)129(217)186-107(70-194)140(228)176-96(146(234)235)38-31-56-164-149(160)161/h22-24,32-33,39-46,72-82,88-108,115-118,193-198H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,199)(H2,154,200)(H2,155,201)(H,165,211)(H,166,210)(H,167,219)(H,168,227)(H,169,202)(H,170,207)(H,171,212)(H,172,213)(H,173,223)(H,174,220)(H,175,231)(H,176,228)(H,177,208)(H,178,214)(H,179,215)(H,180,221)(H,181,229)(H,182,216)(H,183,230)(H,184,232)(H,185,233)(H,186,217)(H,187,222)(H,188,224)(H,189,218)(H,190,209)(H,191,226)(H,192,225)(H,203,204)(H,205,206)(H,234,235)(H4,156,157,162)(H4,158,159,163)(H4,160,161,164)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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KEGG
PC cid
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UniChem

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n/an/a 0.800n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004980
PNG
(CHEMBL262536 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C144H238N42O40S/c1-20-75(13)112(184-118(203)79(17)162-127(212)101(64-109(196)197)171-117(202)77(15)161-119(204)86(147)60-82-39-43-84(191)44-40-82)140(225)178-99(61-81-32-23-22-24-33-81)133(218)186-114(80(18)190)141(226)179-100(63-107(149)194)132(217)182-105(69-189)137(222)175-98(62-83-41-45-85(192)46-42-83)131(216)169-91(38-31-54-159-144(155)156)122(207)168-89(35-26-28-51-146)126(211)183-111(74(11)12)138(223)177-94(56-70(3)4)120(205)160-66-108(195)164-92(47-48-106(148)193)124(209)173-97(59-73(9)10)130(215)181-103(67-187)135(220)163-78(16)116(201)166-90(37-30-53-158-143(153)154)121(206)167-88(34-25-27-50-145)123(208)172-95(57-71(5)6)128(213)174-96(58-72(7)8)129(214)176-102(65-110(198)199)134(219)185-113(76(14)21-2)139(224)170-93(49-55-227-19)125(210)180-104(68-188)136(221)165-87(115(150)200)36-29-52-157-142(151)152/h22-24,32-33,39-46,70-80,86-105,111-114,187-192H,20-21,25-31,34-38,47-69,145-147H2,1-19H3,(H2,148,193)(H2,149,194)(H2,150,200)(H,160,205)(H,161,204)(H,162,212)(H,163,220)(H,164,195)(H,165,221)(H,166,201)(H,167,206)(H,168,207)(H,169,216)(H,170,224)(H,171,202)(H,172,208)(H,173,209)(H,174,213)(H,175,222)(H,176,214)(H,177,223)(H,178,225)(H,179,226)(H,180,210)(H,181,215)(H,182,217)(H,183,211)(H,184,203)(H,185,219)(H,186,218)(H,196,197)(H,198,199)(H4,151,152,157)(H4,153,154,158)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,111-,112-,113-,114-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
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UniChem

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PubMed
n/an/a 45n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Myeloperoxidase (MPO)


(Homo sapiens (Human))
BDBM50008382
PNG
(Ac-Phe-Lys-AspMet-GIn-Leu-Gly-Arg-OH | CHEMBL23706...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccccc1)C(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C45H72N12O13S/c1-25(2)21-33(39(64)51-24-36(60)52-32(44(69)70)14-10-19-50-45(48)49)56-41(66)30(15-16-35(47)59)54-42(67)31(17-20-71-4)55-43(68)34(23-37(61)62)57-40(65)29(13-8-9-18-46)53-38(63)28(26(3)58)22-27-11-6-5-7-12-27/h5-7,11-12,25,28-34H,8-10,13-24,46H2,1-4H3,(H2,47,59)(H,51,64)(H,52,60)(H,53,63)(H,54,67)(H,55,68)(H,56,66)(H,57,65)(H,61,62)(H,69,70)(H4,48,49,50)/t28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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UniChem

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n/an/an/an/a 3.50E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vivo potency of the compound was determined as the maximal lysosomal myeloperoxidase (MPO) release in PMNL assay


J Med Chem 35: 402-6 (1992)


Article DOI: 10.1021/jm00080a030
BindingDB Entry DOI: 10.7270/Q2HH6J1S
More data for this
Ligand-Target Pair
Neurokinin 1 receptor


(GUINEA PIG)
BDBM50001597
PNG
(CHEMBL134481 | N-(1-{1-[1-({[1-(1-Carbamoyl-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(N)=O
Show InChI InChI=1S/C44H66N10O11S/c1-26(2)20-31(41(62)50-30(38(47)59)17-19-66-3)49-36(56)24-48-40(61)32(21-27-12-6-4-7-13-27)52-42(63)33(22-28-14-8-5-9-15-28)53-44(65)35(25-55)54-43(64)34(23-37(57)58)51-39(60)29(46)16-10-11-18-45/h4-9,12-15,26,29-35,55H,10-11,16-25,45-46H2,1-3H3,(H2,47,59)(H,48,61)(H,49,56)(H,50,62)(H,51,60)(H,52,63)(H,53,65)(H,54,64)(H,57,58)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

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UniChem

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PubMed
n/an/an/an/a 45n/an/an/an/a



Glaxo Group Research

Curated by ChEMBL


Assay Description
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.


J Med Chem 35: 4195-204 (1992)


Article DOI: 10.1021/jm00100a027
BindingDB Entry DOI: 10.7270/Q2NZ8883
More data for this
Ligand-Target Pair
TACR2


(mouse)
BDBM50001597
PNG
(CHEMBL134481 | N-(1-{1-[1-({[1-(1-Carbamoyl-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(N)=O
Show InChI InChI=1S/C44H66N10O11S/c1-26(2)20-31(41(62)50-30(38(47)59)17-19-66-3)49-36(56)24-48-40(61)32(21-27-12-6-4-7-13-27)52-42(63)33(22-28-14-8-5-9-15-28)53-44(65)35(25-55)54-43(64)34(23-37(57)58)51-39(60)29(46)16-10-11-18-45/h4-9,12-15,26,29-35,55H,10-11,16-25,45-46H2,1-3H3,(H2,47,59)(H,48,61)(H,49,56)(H,50,62)(H,51,60)(H,52,63)(H,53,65)(H,54,64)(H,57,58)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
Reactome pathway

UniProtKB/SwissProt

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n/an/an/an/a 33n/an/an/an/a



Glaxo Group Research

Curated by ChEMBL


Assay Description
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.


J Med Chem 35: 4195-204 (1992)


Article DOI: 10.1021/jm00100a027
BindingDB Entry DOI: 10.7270/Q2NZ8883
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004978
PNG
(CHEMBL262750 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C153H253N45O43S/c1-20-80(13)120(196-126(217)84(17)172-136(227)107(69-117(210)211)183-125(216)83(16)171-135(226)103(175-115(208)40-29-56-156)66-87-41-45-89(203)46-42-87)149(240)190-105(65-86-33-23-22-24-34-86)142(233)198-122(85(18)202)150(241)191-106(68-114(159)207)141(232)194-111(74-201)146(237)187-104(67-88-43-47-90(204)48-44-88)140(231)180-95(39-32-59-169-153(165)166)129(220)179-93(36-26-28-55-155)134(225)195-119(79(11)12)147(238)189-99(61-75(3)4)127(218)170-71-116(209)174-96(49-51-112(157)205)131(222)185-102(64-78(9)10)139(230)193-109(72-199)144(235)173-82(15)124(215)177-94(38-31-58-168-152(163)164)128(219)178-92(35-25-27-54-154)130(221)184-101(63-77(7)8)138(229)186-100(62-76(5)6)137(228)181-97(50-52-113(158)206)132(223)188-108(70-118(212)213)143(234)197-121(81(14)21-2)148(239)182-98(53-60-242-19)133(224)192-110(73-200)145(236)176-91(123(160)214)37-30-57-167-151(161)162/h22-24,33-34,41-48,75-85,91-111,119-122,199-204H,20-21,25-32,35-40,49-74,154-156H2,1-19H3,(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,214)(H,170,218)(H,171,226)(H,172,227)(H,173,235)(H,174,209)(H,175,208)(H,176,236)(H,177,215)(H,178,219)(H,179,220)(H,180,231)(H,181,228)(H,182,239)(H,183,216)(H,184,221)(H,185,222)(H,186,229)(H,187,237)(H,188,223)(H,189,238)(H,190,240)(H,191,241)(H,192,224)(H,193,230)(H,194,232)(H,195,225)(H,196,217)(H,197,234)(H,198,233)(H,210,211)(H,212,213)(H4,161,162,167)(H4,163,164,168)(H4,165,166,169)/t80-,81-,82-,83-,84-,85+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,119-,120-,121-,122-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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n/an/a 14n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004975
PNG
(CHEMBL428163 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C143H234N42O41S/c1-20-73(13)111(183-117(203)77(17)161-126(212)99(62-108(196)197)170-116(202)75(15)160-118(204)84(145)58-80-36-40-82(190)41-37-80)139(225)177-97(59-79-30-23-22-24-31-79)132(218)185-113(78(18)189)140(226)178-98(61-106(148)194)131(217)181-103(67-188)136(222)174-96(60-81-38-42-83(191)43-39-81)130(216)167-88(35-29-52-158-143(154)155)120(206)166-86(32-25-26-49-144)125(211)182-110(72(11)12)137(223)176-92(54-68(3)4)119(205)159-64-107(195)163-89(44-46-104(146)192)122(208)172-95(57-71(9)10)129(215)180-101(65-186)134(220)162-76(16)115(201)165-87(34-28-51-157-142(152)153)121(207)171-94(56-70(7)8)128(214)173-93(55-69(5)6)127(213)168-90(45-47-105(147)193)123(209)175-100(63-109(198)199)133(219)184-112(74(14)21-2)138(224)169-91(48-53-227-19)124(210)179-102(66-187)135(221)164-85(114(149)200)33-27-50-156-141(150)151/h22-24,30-31,36-43,68-78,84-103,110-113,186-191H,20-21,25-29,32-35,44-67,144-145H2,1-19H3,(H2,146,192)(H2,147,193)(H2,148,194)(H2,149,200)(H,159,205)(H,160,204)(H,161,212)(H,162,220)(H,163,195)(H,164,221)(H,165,201)(H,166,206)(H,167,216)(H,168,213)(H,169,224)(H,170,202)(H,171,207)(H,172,208)(H,173,214)(H,174,222)(H,175,209)(H,176,223)(H,177,225)(H,178,226)(H,179,210)(H,180,215)(H,181,217)(H,182,211)(H,183,203)(H,184,219)(H,185,218)(H,196,197)(H,198,199)(H4,150,151,156)(H4,152,153,157)(H4,154,155,158)/t73-,74-,75-,76-,77-,78+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,110-,111-,112-,113-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
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UniChem

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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004973
PNG
(CHEMBL216479 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C155H257N45O43S/c1-20-82(13)122(198-128(219)86(17)174-138(229)109(71-119(212)213)185-127(218)85(16)173-137(228)105(68-89-43-47-91(205)48-44-89)177-117(210)42-26-23-29-56-156)151(242)192-107(67-88-35-24-22-25-36-88)144(235)200-124(87(18)204)152(243)193-108(70-116(161)209)143(234)196-113(76-203)148(239)189-106(69-90-45-49-92(206)50-46-90)142(233)182-97(41-34-61-171-155(167)168)131(222)181-95(38-28-31-58-158)136(227)197-121(81(11)12)149(240)191-101(63-77(3)4)129(220)172-73-118(211)176-98(51-53-114(159)207)133(224)187-104(66-80(9)10)141(232)195-111(74-201)146(237)175-84(15)126(217)179-96(40-33-60-170-154(165)166)130(221)180-94(37-27-30-57-157)132(223)186-103(65-79(7)8)140(231)188-102(64-78(5)6)139(230)183-99(52-54-115(160)208)134(225)190-110(72-120(214)215)145(236)199-123(83(14)21-2)150(241)184-100(55-62-244-19)135(226)194-112(75-202)147(238)178-93(125(162)216)39-32-59-169-153(163)164/h22,24-25,35-36,43-50,77-87,93-113,121-124,201-206H,20-21,23,26-34,37-42,51-76,156-158H2,1-19H3,(H2,159,207)(H2,160,208)(H2,161,209)(H2,162,216)(H,172,220)(H,173,228)(H,174,229)(H,175,237)(H,176,211)(H,177,210)(H,178,238)(H,179,217)(H,180,221)(H,181,222)(H,182,233)(H,183,230)(H,184,241)(H,185,218)(H,186,223)(H,187,224)(H,188,231)(H,189,239)(H,190,225)(H,191,240)(H,192,242)(H,193,243)(H,194,226)(H,195,232)(H,196,234)(H,197,227)(H,198,219)(H,199,236)(H,200,235)(H,212,213)(H,214,215)(H4,163,164,169)(H4,165,166,170)(H4,167,168,171)/t82-,83-,84-,85-,86-,87+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004974
PNG
(Ac-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C151H248N44O43S/c1-21-78(13)118(193-124(214)82(17)169-134(224)106(67-115(207)208)180-123(213)81(16)168-133(223)102(171-84(19)200)64-86-40-44-88(201)45-41-86)147(237)187-104(63-85-33-24-23-25-34-85)140(230)195-120(83(18)199)148(238)188-105(66-113(156)205)139(229)191-110(72-198)144(234)184-103(65-87-42-46-89(202)47-43-87)138(228)177-94(39-32-57-166-151(162)163)127(217)176-92(36-27-29-54-153)132(222)192-117(77(11)12)145(235)186-98(59-73(3)4)125(215)167-69-114(206)172-95(48-50-111(154)203)129(219)182-101(62-76(9)10)137(227)190-108(70-196)142(232)170-80(15)122(212)174-93(38-31-56-165-150(160)161)126(216)175-91(35-26-28-53-152)128(218)181-100(61-75(7)8)136(226)183-99(60-74(5)6)135(225)178-96(49-51-112(155)204)130(220)185-107(68-116(209)210)141(231)194-119(79(14)22-2)146(236)179-97(52-58-239-20)131(221)189-109(71-197)143(233)173-90(121(157)211)37-30-55-164-149(158)159/h23-25,33-34,40-47,73-83,90-110,117-120,196-199,201-202H,21-22,26-32,35-39,48-72,152-153H2,1-20H3,(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,211)(H,167,215)(H,168,223)(H,169,224)(H,170,232)(H,171,200)(H,172,206)(H,173,233)(H,174,212)(H,175,216)(H,176,217)(H,177,228)(H,178,225)(H,179,236)(H,180,213)(H,181,218)(H,182,219)(H,183,226)(H,184,234)(H,185,220)(H,186,235)(H,187,237)(H,188,238)(H,189,221)(H,190,227)(H,191,229)(H,192,222)(H,193,214)(H,194,231)(H,195,230)(H,207,208)(H,209,210)(H4,158,159,164)(H4,160,161,165)(H4,162,163,166)/t78-,79-,80-,81-,82-,83+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,117-,118-,119-,120-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004971
PNG
(CHEMBL412558 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C145H240N42O40S/c1-20-76(13)113(185-119(204)80(17)163-129(214)102(65-110(197)198)173-118(203)78(15)162-120(205)87(148)62-83-39-43-85(192)44-40-83)141(226)180-101(63-82-32-23-22-24-33-82)134(219)187-115(81(18)191)142(227)183-106(70-190)138(223)177-100(64-84-41-45-86(193)46-42-84)133(218)170-92(38-31-56-160-145(156)157)123(208)169-90(35-26-28-53-147)128(213)184-112(75(11)12)139(224)179-96(58-71(3)4)121(206)161-67-109(196)165-93(47-49-107(149)194)125(210)175-99(61-74(9)10)132(217)182-104(68-188)136(221)164-79(16)117(202)167-91(37-30-55-159-144(154)155)122(207)168-89(34-25-27-52-146)124(209)174-98(60-73(7)8)131(216)176-97(59-72(5)6)130(215)171-94(48-50-108(150)195)126(211)178-103(66-111(199)200)135(220)186-114(77(14)21-2)140(225)172-95(51-57-228-19)127(212)181-105(69-189)137(222)166-88(116(151)201)36-29-54-158-143(152)153/h22-24,32-33,39-46,71-81,87-106,112-115,188-193H,20-21,25-31,34-38,47-70,146-148H2,1-19H3,(H2,149,194)(H2,150,195)(H2,151,201)(H,161,206)(H,162,205)(H,163,214)(H,164,221)(H,165,196)(H,166,222)(H,167,202)(H,168,207)(H,169,208)(H,170,218)(H,171,215)(H,172,225)(H,173,203)(H,174,209)(H,175,210)(H,176,216)(H,177,223)(H,178,211)(H,179,224)(H,180,226)(H,181,212)(H,182,217)(H,183,227)(H,184,213)(H,185,204)(H,186,220)(H,187,219)(H,197,198)(H,199,200)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,112-,113-,114-,115-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 95n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004970
PNG
(CHEMBL438545 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C146H241N43O40S/c1-20-76(13)114(187-120(206)80(17)165-130(216)103(66-111(199)200)175-119(205)78(15)164-121(207)87(149)62-83-39-43-85(193)44-40-83)142(228)182-101(63-82-32-23-22-24-33-82)136(222)189-116(81(18)192)143(229)183-102(65-109(152)197)135(221)185-106(70-191)139(225)179-100(64-84-41-45-86(194)46-42-84)134(220)172-92(38-31-56-162-146(158)159)124(210)171-90(35-26-28-53-148)129(215)186-113(75(11)12)140(226)181-96(58-71(3)4)122(208)163-68-110(198)167-93(47-49-107(150)195)126(212)177-99(61-74(9)10)133(219)184-105(69-190)138(224)166-79(16)118(204)169-91(37-30-55-161-145(156)157)123(209)170-89(34-25-27-52-147)125(211)176-98(60-73(7)8)132(218)178-97(59-72(5)6)131(217)173-94(48-50-108(151)196)127(213)180-104(67-112(201)202)137(223)188-115(77(14)21-2)141(227)174-95(51-57-230-19)128(214)168-88(117(153)203)36-29-54-160-144(154)155/h22-24,32-33,39-46,71-81,87-106,113-116,190-194H,20-21,25-31,34-38,47-70,147-149H2,1-19H3,(H2,150,195)(H2,151,196)(H2,152,197)(H2,153,203)(H,163,208)(H,164,207)(H,165,216)(H,166,224)(H,167,198)(H,168,214)(H,169,204)(H,170,209)(H,171,210)(H,172,220)(H,173,217)(H,174,227)(H,175,205)(H,176,211)(H,177,212)(H,178,218)(H,179,225)(H,180,213)(H,181,226)(H,182,228)(H,183,229)(H,184,219)(H,185,221)(H,186,215)(H,187,206)(H,188,223)(H,189,222)(H,199,200)(H,201,202)(H4,154,155,160)(H4,156,157,161)(H4,158,159,162)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Neurokinin 3 receptor


(Rattus norvegicus)
BDBM50001597
PNG
(CHEMBL134481 | N-(1-{1-[1-({[1-(1-Carbamoyl-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(N)=O
Show InChI InChI=1S/C44H66N10O11S/c1-26(2)20-31(41(62)50-30(38(47)59)17-19-66-3)49-36(56)24-48-40(61)32(21-27-12-6-4-7-13-27)52-42(63)33(22-28-14-8-5-9-15-28)53-44(65)35(25-55)54-43(64)34(23-37(57)58)51-39(60)29(46)16-10-11-18-45/h4-9,12-15,26,29-35,55H,10-11,16-25,45-46H2,1-3H3,(H2,47,59)(H,48,61)(H,49,56)(H,50,62)(H,51,60)(H,52,63)(H,53,65)(H,54,64)(H,57,58)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 857n/an/an/an/a



Glaxo Group Research

Curated by ChEMBL


Assay Description
In vitro agonistic activity against tachykinin receptor 3 of everted rat protal vein.


J Med Chem 35: 4195-204 (1992)


Article DOI: 10.1021/jm00100a027
BindingDB Entry DOI: 10.7270/Q2NZ8883
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004966
PNG
(CHEMBL428135 | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C149H246N44O42S/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158/h22-24,32-33,39-46,72-82,88-108,115-118,194-199H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,200)(H2,154,201)(H2,155,202)(H2,156,208)(H,166,213)(H,167,212)(H,168,221)(H,169,229)(H,170,203)(H,171,230)(H,172,209)(H,173,214)(H,174,215)(H,175,225)(H,176,222)(H,177,233)(H,178,210)(H,179,216)(H,180,217)(H,181,223)(H,182,231)(H,183,218)(H,184,232)(H,185,234)(H,186,235)(H,187,219)(H,188,224)(H,189,226)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-/m0/s1
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KEGG
PC cid
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UniChem

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PubMed
n/an/a 5.60n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004965
PNG
(CHEMBL269263 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C134H217N37O39S/c1-19-69(13)105(169-110(188)72(16)149-118(196)93(58-102(182)183)156-109(187)71(15)148-111(189)79(136)54-75-33-37-77(176)38-34-75)131(209)163-91(55-74-28-22-21-23-29-74)124(202)171-107(73(17)175)132(210)164-92(57-100(139)180)123(201)167-97(63-174)128(206)160-90(56-76-35-39-78(177)40-36-76)122(200)153-82(32-27-48-146-134(143)144)113(191)152-81(30-24-25-46-135)117(195)168-104(68(11)12)129(207)162-86(50-64(3)4)112(190)147-60-101(181)150-83(41-43-98(137)178)114(192)157-89(53-67(9)10)121(199)166-96(62-173)127(205)159-88(52-66(7)8)120(198)158-87(51-65(5)6)119(197)154-84(42-44-99(138)179)115(193)161-94(59-103(184)185)125(203)170-106(70(14)20-2)130(208)155-85(45-49-211-18)116(194)165-95(61-172)126(204)151-80(108(140)186)31-26-47-145-133(141)142/h21-23,28-29,33-40,64-73,79-97,104-107,172-177H,19-20,24-27,30-32,41-63,135-136H2,1-18H3,(H2,137,178)(H2,138,179)(H2,139,180)(H2,140,186)(H,147,190)(H,148,189)(H,149,196)(H,150,181)(H,151,204)(H,152,191)(H,153,200)(H,154,197)(H,155,208)(H,156,187)(H,157,192)(H,158,198)(H,159,205)(H,160,206)(H,161,193)(H,162,207)(H,163,209)(H,164,210)(H,165,194)(H,166,199)(H,167,201)(H,168,195)(H,169,188)(H,170,203)(H,171,202)(H,182,183)(H,184,185)(H4,141,142,145)(H4,143,144,146)/t69-,70-,71-,72-,73+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,104-,105-,106-,107-/m0/s1
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UniProtKB/SwissProt

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n/an/a 1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-GRF in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004964
PNG
(CHEMBL412221 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C147H243N43O41S/c1-20-76(13)114(188-120(207)80(17)165-129(216)103(66-111(200)201)175-119(206)78(15)164-121(208)87(150)62-83-39-43-85(195)44-40-83)143(230)182-101(63-82-32-23-22-24-33-82)136(223)190-116(81(18)194)144(231)183-102(65-110(153)199)135(222)186-107(70-193)140(227)179-100(64-84-41-45-86(196)46-42-84)134(221)171-92(38-31-56-163-147(159)160)123(210)170-90(35-26-28-53-149)128(215)187-113(75(11)12)141(228)181-99(61-74(9)10)131(218)173-93(47-49-108(151)197)125(212)177-98(60-73(7)8)133(220)185-105(68-191)138(225)166-79(16)118(205)168-91(37-30-55-162-146(157)158)122(209)169-89(34-25-27-52-148)124(211)176-97(59-72(5)6)132(219)178-96(58-71(3)4)130(217)172-94(48-50-109(152)198)126(213)180-104(67-112(202)203)137(224)189-115(77(14)21-2)142(229)174-95(51-57-232-19)127(214)184-106(69-192)139(226)167-88(117(154)204)36-29-54-161-145(155)156/h22-24,32-33,39-46,71-81,87-107,113-116,191-196H,20-21,25-31,34-38,47-70,148-150H2,1-19H3,(H2,151,197)(H2,152,198)(H2,153,199)(H2,154,204)(H,164,208)(H,165,216)(H,166,225)(H,167,226)(H,168,205)(H,169,209)(H,170,210)(H,171,221)(H,172,217)(H,173,218)(H,174,229)(H,175,206)(H,176,211)(H,177,212)(H,178,219)(H,179,227)(H,180,213)(H,181,228)(H,182,230)(H,183,231)(H,184,214)(H,185,220)(H,186,222)(H,187,215)(H,188,207)(H,189,224)(H,190,223)(H,200,201)(H,202,203)(H4,155,156,161)(H4,157,158,162)(H4,159,160,163)/t76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,113-,114-,115-,116-/m0/s1
Reactome pathway
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n/an/a 1.00E+3n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair
Growth hormone-releasing hormone receptor


(Rattus norvegicus)
BDBM50004968
PNG
(CHEMBL439108 | GRF-analogues)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C157H261N45O43S/c1-20-84(13)124(200-130(221)88(17)176-140(231)111(73-121(214)215)187-129(220)87(16)175-139(230)107(70-91-45-49-93(207)50-46-91)179-119(212)44-28-23-22-24-31-58-158)153(244)194-109(69-90-37-26-25-27-38-90)146(237)202-126(89(18)206)154(245)195-110(72-118(163)211)145(236)198-115(78-205)150(241)191-108(71-92-47-51-94(208)52-48-92)144(235)184-99(43-36-63-173-157(169)170)133(224)183-97(40-30-33-60-160)138(229)199-123(83(11)12)151(242)193-103(65-79(3)4)131(222)174-75-120(213)178-100(53-55-116(161)209)135(226)189-106(68-82(9)10)143(234)197-113(76-203)148(239)177-86(15)128(219)181-98(42-35-62-172-156(167)168)132(223)182-96(39-29-32-59-159)134(225)188-105(67-81(7)8)142(233)190-104(66-80(5)6)141(232)185-101(54-56-117(162)210)136(227)192-112(74-122(216)217)147(238)201-125(85(14)21-2)152(243)186-102(57-64-246-19)137(228)196-114(77-204)149(240)180-95(127(164)218)41-34-61-171-155(165)166/h25-27,37-38,45-52,79-89,95-115,123-126,203-208H,20-24,28-36,39-44,53-78,158-160H2,1-19H3,(H2,161,209)(H2,162,210)(H2,163,211)(H2,164,218)(H,174,222)(H,175,230)(H,176,231)(H,177,239)(H,178,213)(H,179,212)(H,180,240)(H,181,219)(H,182,223)(H,183,224)(H,184,235)(H,185,232)(H,186,243)(H,187,220)(H,188,225)(H,189,226)(H,190,233)(H,191,241)(H,192,227)(H,193,242)(H,194,244)(H,195,245)(H,196,228)(H,197,234)(H,198,236)(H,199,229)(H,200,221)(H,201,238)(H,202,237)(H,214,215)(H,216,217)(H4,165,166,171)(H4,167,168,172)(H4,169,170,173)/t84-,85-,86-,87-,88-,89+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,123-,124-,125-,126-/m0/s1
Reactome pathway
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UniProtKB/SwissProt

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UniChem

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n/an/a 22n/an/an/an/an/an/a



Notre-Dame Hospital Research

Curated by ChEMBL


Assay Description
Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates


J Med Chem 35: 1864-9 (1992)


Article DOI: 10.1021/jm00088a023
BindingDB Entry DOI: 10.7270/Q2Z0373P
More data for this
Ligand-Target Pair