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42 similar compounds to monomer 50021230

Compile data set for download or QSAR
Wt: 292.2
BDBM81946
Wt: 464.2
BDBM50026958
Wt: 362.3
BDBM50021216
Wt: 334.2
BDBM50021220
Wt: 332.2
BDBM50021223
Wt: 361.3
BDBM50021224
Purchase
Wt: 346.2
BDBM50021229
Wt: 320.2
BDBM50021242
Wt: 271.7
BDBM50021211
Wt: 292.2
BDBM50021226
Wt: 257.7
BDBM50021235
Wt: 271.7
BDBM50021238
Wt: 257.7
BDBM50021243
Wt: 306.2
BDBM50021245
Wt: 405.3
BDBM50026953
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 137 hits for monomerid = 81946,50026958,50021216,50021220,50021223,50021224,50021229,50021242,50021211,50021226,50021235,50021238,50021243,50021245,50026953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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0.130n/an/an/an/an/an/an/an/a



Boots Pharmaceuticals

Curated by PDSP Ki Database




Neuropharmacology 32: 737-43 (1993)


Article DOI: 10.1016/0028-3908(93)90181-2
BindingDB Entry DOI: 10.7270/Q22J69D4
More data for this
Ligand-Target Pair
Norepinephrine transporter


(RAT)
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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0.260n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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0.400n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranes


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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0.410n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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0.480n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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0.990n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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1n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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1.5n/an/an/an/an/an/an/an/a



Boots Pharmaceuticals

Curated by PDSP Ki Database




Neuropharmacology 32: 737-43 (1993)


Article DOI: 10.1016/0028-3908(93)90181-2
BindingDB Entry DOI: 10.7270/Q22J69D4
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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1.70n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranes


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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1.90n/an/an/an/an/an/an/an/a



NIH

Curated by PDSP Ki Database




Synapse 39: 32-41 (2001)


Article DOI: 10.1002/1098-2396(20010101)39:1
BindingDB Entry DOI: 10.7270/Q2NV9GT3
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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2n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Reuptake inhibitory activity against dopamine DA transporter


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Reuptake inhibitory activity against Serotonin transporter


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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3.10n/an/an/an/an/an/an/an/a



NIH

Curated by PDSP Ki Database




Synapse 39: 32-41 (2001)


Article DOI: 10.1002/1098-2396(20010101)39:1
BindingDB Entry DOI: 10.7270/Q2NV9GT3
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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3.20n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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5.10n/an/an/an/an/an/an/an/a



Novo Industri A/S

Curated by PDSP Ki Database




Eur J Pharmacol 166: 493-504 (1989)


Article DOI: 10.1016/0014-2999(89)90363-4
BindingDB Entry DOI: 10.7270/Q28C9TR3
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus)
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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6n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranes


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Norepinephrine transporter


(RAT)
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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8.80n/an/an/an/an/an/an/an/a



Novo Industri A/S

Curated by PDSP Ki Database




Eur J Pharmacol 166: 493-504 (1989)


Article DOI: 10.1016/0014-2999(89)90363-4
BindingDB Entry DOI: 10.7270/Q28C9TR3
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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11n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Reuptake inhibitory activity against NE transporter


J Med Chem 47: 2624-34 (2004)


Article DOI: 10.1021/jm0305873
BindingDB Entry DOI: 10.7270/Q2MK6DF4
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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11.9n/an/an/an/an/an/an/an/a



Novo Industri A/S

Curated by PDSP Ki Database




Eur J Pharmacol 166: 493-504 (1989)


Article DOI: 10.1016/0014-2999(89)90363-4
BindingDB Entry DOI: 10.7270/Q28C9TR3
More data for this
Ligand-Target Pair
Norepinephrine transporter


(RAT)
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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12.6n/an/an/an/an/an/an/an/a



NIH

Curated by PDSP Ki Database




Synapse 39: 32-41 (2001)


Article DOI: 10.1002/1098-2396(20010101)39:1
BindingDB Entry DOI: 10.7270/Q2NV9GT3
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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13n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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290n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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740n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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890n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Mol Pharmacol 45: 125-35 (1994)


BindingDB Entry DOI: 10.7270/Q2NG4P5C
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM81946
PNG
(CAS_96850-13-4 | LU 19,005 | LU 19-005)
Show SMILES CN[C@H]1C[C@@H](c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3/t13-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lundbeck AIS

Curated by PDSP Ki Database




J Neurochem 44: 1615-22 (1985)


Article DOI: 10.1111/j.1471-4159.1985.tb08803.x
BindingDB Entry DOI: 10.7270/Q27H1H2F
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50026958
PNG
((cis) 2-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H24Cl2N2O.2ClH/c22-19-6-5-15(13-20(19)23)18-14-21(17-4-2-1-3-16(17)18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,18,21,26H,7-12,14H2;2*1H
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50026953
PNG
((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Show SMILES OCCCN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H26Cl2N2O/c23-20-7-6-16(14-21(20)24)19-15-22(18-5-2-1-4-17(18)19)26-11-9-25(10-12-26)8-3-13-27/h1-2,4-7,14,19,22,27H,3,8-13,15H2
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n/an/a 6.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of Noradrenaline (NA)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021224
PNG
((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Show SMILES CN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2N2/c1-23-8-10-24(11-9-23)20-13-17(15-4-2-3-5-16(15)20)14-6-7-18(21)19(22)12-14/h2-7,12,17,20H,8-11,13H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50026958
PNG
((cis) 2-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H24Cl2N2O.2ClH/c22-19-6-5-15(13-20(19)23)18-14-21(17-4-2-1-3-16(17)18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,18,21,26H,7-12,14H2;2*1H
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of Noradrenaline (NA)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021220
PNG
(CHEMBL555549 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Show SMILES CCN(CC)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H21Cl2N/c1-3-22(4-2)19-12-16(14-7-5-6-8-15(14)19)13-9-10-17(20)18(21)11-13/h5-11,16,19H,3-4,12H2,1-2H3
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n/an/a 0.560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021245
PNG
(CHEMBL301782 | CHEMBL552891 | [3-(3,4-Dichloro-phe...)
Show SMILES CN(C)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H17Cl2N/c1-20(2)17-10-14(12-5-3-4-6-13(12)17)11-7-8-15(18)16(19)9-11/h3-9,14,17H,10H2,1-2H3
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n/an/a 0.370n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021216
PNG
(CHEMBL543320 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Show SMILES CCCN(CCC)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H25Cl2N/c1-3-11-24(12-4-2)21-14-18(16-7-5-6-8-17(16)21)15-9-10-19(22)20(23)13-15/h5-10,13,18,21H,3-4,11-12,14H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021211
PNG
(CHEMBL543324 | [3-(3-Chloro-phenyl)-indan-1-yl]-di...)
Show SMILES CN(C)C1CC(c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClN/c1-19(2)17-11-16(12-6-5-7-13(18)10-12)14-8-3-4-9-15(14)17/h3-10,16-17H,11H2,1-2H3
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n/an/a 2.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021211
PNG
(CHEMBL543324 | [3-(3-Chloro-phenyl)-indan-1-yl]-di...)
Show SMILES CN(C)C1CC(c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClN/c1-19(2)17-11-16(12-6-5-7-13(18)10-12)14-8-3-4-9-15(14)17/h3-10,16-17H,11H2,1-2H3
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n/an/a 54n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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n/an/a 0.260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021238
PNG
(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Show SMILES CN(C)C1CC(c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H18ClN/c1-19(2)17-11-16(12-7-9-13(18)10-8-12)14-5-3-4-6-15(14)17/h3-10,16-17H,11H2,1-2H3
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n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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n/an/a 0.480n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021224
PNG
((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Show SMILES CN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2N2/c1-23-8-10-24(11-9-23)20-13-17(15-4-2-3-5-16(15)20)14-6-7-18(21)19(22)12-14/h2-7,12,17,20H,8-11,13H2,1H3
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021235
PNG
(CHEMBL51224 | CHEMBL554756 | [3-(4-Chloro-phenyl)-...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H16ClN/c1-18-16-10-15(11-6-8-12(17)9-7-11)13-4-2-3-5-14(13)16/h2-9,15-16,18H,10H2,1H3
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n/an/a 24n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021243
PNG
(CHEMBL544500 | [3-(3-Chloro-phenyl)-indan-1-yl]-me...)
Show SMILES CNC1CC(c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H16ClN/c1-18-16-10-15(11-5-4-6-12(17)9-11)13-7-2-3-8-14(13)16/h2-9,15-16,18H,10H2,1H3
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n/an/a 41n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021226
PNG
(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Show SMILES CNC1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H15Cl2N/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10/h2-8,13,16,19H,9H2,1H3
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n/an/a 0.990n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021238
PNG
(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Show SMILES CN(C)C1CC(c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H18ClN/c1-19(2)17-11-16(12-7-9-13(18)10-8-12)14-5-3-4-6-15(14)17/h3-10,16-17H,11H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021243
PNG
(CHEMBL544500 | [3-(3-Chloro-phenyl)-indan-1-yl]-me...)
Show SMILES CNC1CC(c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H16ClN/c1-18-16-10-15(11-5-4-6-12(17)9-11)13-7-2-3-8-14(13)16/h2-9,15-16,18H,10H2,1H3
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n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50021220
PNG
(CHEMBL555549 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Show SMILES CCN(CC)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H21Cl2N/c1-3-22(4-2)19-12-16(14-7-5-6-8-15(14)19)13-9-10-17(20)18(21)11-13/h5-11,16,19H,3-4,12H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))
BDBM50021223
PNG
(1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pyrrolidine...)
Show SMILES Clc1ccc(cc1Cl)C1CC(N2CCCC2)c2ccccc12
Show InChI InChI=1S/C19H19Cl2N/c20-17-8-7-13(11-18(17)21)16-12-19(22-9-3-4-10-22)15-6-2-1-5-14(15)16/h1-2,5-8,11,16,19H,3-4,9-10,12H2
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dopamine uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50026953
PNG
((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Show SMILES OCCCN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H26Cl2N2O/c23-20-7-6-16(14-21(20)24)19-15-22(18-5-2-1-4-17(18)19)26-11-9-25(10-12-26)8-3-13-27/h1-2,4-7,14,19,22,27H,3,8-13,15H2
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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021224
PNG
((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Show SMILES CN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2N2/c1-23-8-10-24(11-9-23)20-13-17(15-4-2-3-5-16(15)20)14-6-7-18(21)19(22)12-14/h2-7,12,17,20H,8-11,13H2,1H3
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n/an/a 910n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect on synaptosomal uptake inhibition of Noradrenaline (NA)


J Med Chem 26: 935-47 (1983)


Article DOI: 10.1021/jm00361a002
BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021229
PNG
(1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-piperidine;...)
Show SMILES Clc1ccc(cc1Cl)C1CC(N2CCCCC2)c2ccccc12
Show InChI InChI=1S/C20H21Cl2N/c21-18-9-8-14(12-19(18)22)17-13-20(23-10-4-1-5-11-23)16-7-3-2-6-15(16)17/h2-3,6-9,12,17,20H,1,4-5,10-11,13H2
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n/an/a 79n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50021211
PNG
(CHEMBL543324 | [3-(3-Chloro-phenyl)-indan-1-yl]-di...)
Show SMILES CN(C)C1CC(c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClN/c1-19(2)17-11-16(12-6-5-7-13(18)10-12)14-8-3-4-9-15(14)17/h3-10,16-17H,11H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction


J Med Chem 28: 1817-28 (1986)


Article DOI: 10.1021/jm00150a012
BindingDB Entry DOI: 10.7270/Q29W0G1M
More data for this
Ligand-Target Pair
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