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15 similar compounds to monomer 50009591

Compile data set for download or QSAR
Wt: 243.3
BDBM83449
Purchase
Wt: 241.3
BDBM50004109
Wt: 241.3
BDBM50004110
Wt: 241.3
BDBM50004111
Wt: 241.3
BDBM50004112
Wt: 241.3
BDBM50004113
Wt: 257.4
BDBM50009592
Wt: 257.4
BDBM50018931
Wt: 257.4
BDBM50018932
Wt: 257.4
BDBM50018933
Wt: 257.4
BDBM50018929
Wt: 257.4
BDBM50018930
Wt: 203.3
BDBM50028055
Purchase
Wt: 255.3
BDBM50405723
Wt: 255.3
BDBM50405724

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 58 hits for monomerid = 83449,50004109,50004110,50004111,50004112,50004113,50009592,50018931,50018932,50018933,50018929,50018930,50028055,50405723,50405724   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
OPIATE Sigma


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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29n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




J Pharmacol Exp Ther 233: 597-602 (1985)


BindingDB Entry DOI: 10.7270/Q20R9MWQ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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48n/an/an/an/an/an/an/an/a



The Johns Hopkins University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 238: 739-48 (1986)


BindingDB Entry DOI: 10.7270/Q2C24TX8
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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53n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


J Med Chem 34: 2615-23 (1991)


Article DOI: 10.1021/jm00112a041
BindingDB Entry DOI: 10.7270/Q22806K3
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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60n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018929
PNG
(3-Methyl-1-(1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCN(C1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-14-19(15-16)18(12-6-3-7-13-18)17-10-4-2-5-11-17/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3
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60n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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65n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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66n/an/an/an/an/an/an/an/a



The Johns Hopkins University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 238: 739-48 (1986)


BindingDB Entry DOI: 10.7270/Q2C24TX8
More data for this
Ligand-Target Pair
Glutamate NMDA receptor; Grin1/Grin2c


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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91n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
OPIATE Sigma


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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135n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




J Pharmacol Exp Ther 233: 597-602 (1985)


BindingDB Entry DOI: 10.7270/Q20R9MWQ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50009592
PNG
(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Show SMILES CC1CCC(CC1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-12-18(13-11-16,17-8-4-2-5-9-17)19-14-6-3-7-15-19/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3
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166n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


J Med Chem 34: 2615-23 (1991)


Article DOI: 10.1021/jm00112a041
BindingDB Entry DOI: 10.7270/Q22806K3
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018933
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@H]1CCC[C@@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18-/m0/s1
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170n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
HTR3A


(GUINEA PIG)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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273n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 267: 961-70 (1993)


Article DOI: 10.1016/j.bioorg.2015.05.005
BindingDB Entry DOI: 10.7270/Q2125R5V
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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311n/an/an/an/an/an/an/an/a



The Johns Hopkins University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 238: 739-48 (1986)


BindingDB Entry DOI: 10.7270/Q2C24TX8
More data for this
Ligand-Target Pair
Butyrylcholinesterase


(Mus musculus (Mouse))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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520n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes


J Med Chem 27: 1267-71 (1984)


Article DOI: 10.1021/jm00376a006
BindingDB Entry DOI: 10.7270/Q22Z14J3
More data for this
Ligand-Target Pair
Butyrylcholinesterase


(Mus musculus (Mouse))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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525n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
-Log (Ki) value for butyrylcholinesterase by inhibiting DFP


J Med Chem 27: 1267-71 (1984)


Article DOI: 10.1021/jm00376a006
BindingDB Entry DOI: 10.7270/Q22Z14J3
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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530n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004109
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@@H]2CC[C@@]([C@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17+/m0/s1
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582n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50009592
PNG
(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Show SMILES CC1CCC(CC1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-10-12-18(13-11-16,17-8-4-2-5-9-17)19-14-6-3-7-15-19/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3
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617n/an/an/an/an/an/an/an/a



Istituto Superiore di Sanità

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...


J Med Chem 34: 2615-23 (1991)


Article DOI: 10.1021/jm00112a041
BindingDB Entry DOI: 10.7270/Q22806K3
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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625n/an/an/an/an/an/an/an/a



The Johns Hopkins University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 238: 739-48 (1986)


BindingDB Entry DOI: 10.7270/Q2C24TX8
More data for this
Ligand-Target Pair
Glutamate NMDA receptor; Grin1/Grin2c


(Rattus norvegicus (Rat))
BDBM50405724
PNG
(CHEMBL1169565)
Show SMILES C1C2CC(CC12)[C@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m1/s1
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630n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCP


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004111
PNG
(1-(3-Phenyl-bicyclo[3.1.0]hex-3-yl)-piperidine | C...)
Show SMILES C1[C@H]2C[C@](C[C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-16(8-4-1)17(12-14-11-15(14)13-17)18-9-5-2-6-10-18/h1,3-4,7-8,14-15H,2,5-6,9-13H2/t14-,15+,17+
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644n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405723
PNG
(CHEMBL1169564)
Show SMILES C1C2CC(CC12)[C@@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m0/s1
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680n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCP


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
OPIATE Sigma


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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711n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 81: 4983-7 (1984)


BindingDB Entry DOI: 10.7270/Q2JM284N
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004113
PNG
(1-(3-Phenyl-bicyclo[3.1.0]hex-3-yl)-piperidine | C...)
Show SMILES C1[C@H]2C[C@@](C[C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-16(8-4-1)17(12-14-11-15(14)13-17)18-9-5-2-6-10-18/h1,3-4,7-8,14-15H,2,5-6,9-13H2/t14-,15+,17-
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711n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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758n/an/an/an/an/an/an/an/a



The Johns Hopkins University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 238: 739-48 (1986)


BindingDB Entry DOI: 10.7270/Q2C24TX8
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018932
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@@H]1CCC[C@@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18+/m1/s1
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820n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
OPIATE Sigma


(RAT)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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956n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 81: 4983-7 (1984)


BindingDB Entry DOI: 10.7270/Q2JM284N
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




J Pharm Pharmacol 38: 374-9 (1986)


BindingDB Entry DOI: 10.7270/Q2JS9NXW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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1.05E+3n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




J Pharm Pharmacol 38: 374-9 (1986)


BindingDB Entry DOI: 10.7270/Q2JS9NXW
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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1.09E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50004112
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@@H]2CC[C@]([C@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17-/m0/s1
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1.13E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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1.77E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-pentazocine binding to sigma receptor of guinea pig brain homogenates


J Med Chem 36: 1188-93 (1993)


Article DOI: 10.1021/jm00061a009
BindingDB Entry DOI: 10.7270/Q23F4Q98
More data for this
Ligand-Target Pair
Glutamate NMDA receptor; Grin1/Grin2c


(Rattus norvegicus (Rat))
BDBM50018929
PNG
(3-Methyl-1-(1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES CC1CCCN(C1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-14-19(15-16)18(12-6-3-7-13-18)17-10-4-2-5-11-17/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3
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2.15E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition activity against binding of phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
Glutamate NMDA receptor; Grin1/Grin2c


(Rattus norvegicus (Rat))
BDBM50405723
PNG
(CHEMBL1169564)
Show SMILES C1C2CC(CC12)[C@@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
HTR3A


(GUINEA PIG)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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2.67E+3n/an/an/an/an/an/an/an/a



Syntex Discovery Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 267: 961-70 (1993)


Article DOI: 10.1016/j.bioorg.2015.05.005
BindingDB Entry DOI: 10.7270/Q2125R5V
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50405724
PNG
(CHEMBL1169565)
Show SMILES C1C2CC(CC12)[C@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H25N/c1-3-7-14(8-4-1)18(19-9-5-2-6-10-19)17-12-15-11-16(15)13-17/h1,3-4,7-8,15-18H,2,5-6,9-13H2/t15?,16?,17?,18-/m1/s1
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3.20E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes, Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047


J Med Chem 31: 1571-5 (1988)


Article DOI: 10.1021/jm00403a014
BindingDB Entry DOI: 10.7270/Q2WD41S2
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018931
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@H]1CCC[C@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18+/m0/s1
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3.30E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50004113
PNG
(1-(3-Phenyl-bicyclo[3.1.0]hex-3-yl)-piperidine | C...)
Show SMILES C1[C@H]2C[C@@](C[C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-16(8-4-1)17(12-14-11-15(14)13-17)18-9-5-2-6-10-18/h1,3-4,7-8,14-15H,2,5-6,9-13H2/t14-,15+,17-
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3.72E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50004109
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@@H]2CC[C@@]([C@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17+/m0/s1
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4.45E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50018930
PNG
(1-(3-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Show SMILES C[C@@H]1CCC[C@](C1)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H27N/c1-16-9-8-12-18(15-16,17-10-4-2-5-11-17)19-13-6-3-7-14-19/h2,4-5,10-11,16H,3,6-9,12-15H2,1H3/t16-,18-/m1/s1
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6.80E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.


J Med Chem 31: 1625-8 (1988)


Article DOI: 10.1021/jm00403a023
BindingDB Entry DOI: 10.7270/Q2M044DR
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50004110
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@H]2CC[C@@]([C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17-/m1/s1
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7.28E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004112
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@@H]2CC[C@]([C@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17-/m0/s1
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8.22E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Cytochrome P450 2B6


(Homo sapiens (Human))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Mechanism based inhibition of human cytochrome P450 2B6


Curr Drug Metab 6: 413-54 (2005)


Article DOI: 10.2174/138920005774330639
BindingDB Entry DOI: 10.7270/Q2VQ33X3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50004111
PNG
(1-(3-Phenyl-bicyclo[3.1.0]hex-3-yl)-piperidine | C...)
Show SMILES C1[C@H]2C[C@](C[C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-16(8-4-1)17(12-14-11-15(14)13-17)18-9-5-2-6-10-18/h1,3-4,7-8,14-15H,2,5-6,9-13H2/t14-,15+,17+
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1.63E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-(+)-pentazocine from sigma receptor in Guinea pig brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004110
PNG
(1-(2-Phenyl-bicyclo[3.1.0]hex-2-yl)-piperidine | C...)
Show SMILES C1[C@H]2CC[C@@]([C@@H]12)(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H23N/c1-3-7-15(8-4-1)17(10-9-14-13-16(14)17)18-11-5-2-6-12-18/h1,3-4,7-8,14,16H,2,5-6,9-13H2/t14-,16+,17-/m1/s1
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2.90E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor in rat brain


J Med Chem 35: 4704-12 (1993)


Article DOI: 10.1021/jm00103a008
BindingDB Entry DOI: 10.7270/Q2NP23CB
More data for this
Ligand-Target Pair
Butyrylcholinesterase


(Mus musculus (Mouse))
BDBM50028055
PNG
(CHEMBL279924 | Ethyl-(1-phenyl-cyclohexyl)-amine |...)
Show SMILES CCNC1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C14H21N/c1-2-15-14(11-7-4-8-12-14)13-9-5-3-6-10-13/h3,5-6,9-10,15H,2,4,7-8,11-12H2,1H3
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5.75E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
-Log (Ki) value for butyrylcholinesterase by inhibiting DFP


J Med Chem 27: 1267-71 (1984)


Article DOI: 10.1021/jm00376a006
BindingDB Entry DOI: 10.7270/Q22Z14J3
More data for this
Ligand-Target Pair
Butyrylcholinesterase


(Mus musculus (Mouse))
BDBM50028055
PNG
(CHEMBL279924 | Ethyl-(1-phenyl-cyclohexyl)-amine |...)
Show SMILES CCNC1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C14H21N/c1-2-15-14(11-7-4-8-12-14)13-9-5-3-6-10-13/h3,5-6,9-10,15H,2,4,7-8,11-12H2,1H3
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5.80E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes


J Med Chem 27: 1267-71 (1984)


Article DOI: 10.1021/jm00376a006
BindingDB Entry DOI: 10.7270/Q22Z14J3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [3H]DTG to sigma receptor in Guinea pig brain membranes


J Med Chem 35: 4683-9 (1993)


Article DOI: 10.1021/jm00103a005
BindingDB Entry DOI: 10.7270/Q20865XT
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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n/an/a 560n/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranes


J Med Chem 35: 4683-9 (1993)


Article DOI: 10.1021/jm00103a005
BindingDB Entry DOI: 10.7270/Q20865XT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Mus musculus-MOUSE)
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
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n/an/an/a 9.10E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes


J Med Chem 27: 1267-71 (1984)


Article DOI: 10.1021/jm00376a006
BindingDB Entry DOI: 10.7270/Q22Z14J3
More data for this
Ligand-Target Pair
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