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13 similar compounds to monomer 135629

Compile data set for download or QSAR
Wt: 823.0
BDBM84641
Wt: 794.9
BDBM84642
Wt: 794.9
BDBM84644
Wt: 1106.3
BDBM50405764
Wt: 1120.3
BDBM50405766
Wt: 989.1
BDBM135619
Wt: 1134.2
BDBM135669
Wt: 1133.3
BDBM135630
Wt: 1031.1
BDBM135650
Wt: 1065.2
BDBM135749
Wt: 1017.1
BDBM135618
Wt: 1141.7
BDBM160201
Wt: 1155.7
BDBM160217

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 84641,84642,84644,50405764,50405766,135619,135669,135630,135650,135749,135618,160201,160217   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160201
PNG
(US9040663, 47)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@H](COCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73ClN16O10/c1-31(72)65-39(19-10-24-62-53(57)58)47(75)68-41-21-22-45(73)61-23-9-18-38(46(56)74)66-50(78)43(27-34-28-64-37-17-8-6-15-35(34)37)69-48(76)40(20-11-25-63-54(59)60)67-51(79)42(26-33-14-5-7-16-36(33)55)70-52(80)44(71-49(41)77)30-81-29-32-12-3-2-4-13-32/h2-8,12-17,28,38-44,64H,9-11,18-27,29-30H2,1H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,79)(H,68,75)(H,69,76)(H,70,80)(H,71,77)(H4,57,58,62)(H4,59,60,63)/t38-,39-,40-,41-,42+,43-,44-/m0/s1
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US Patent
0.300 -13.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160217
PNG
(US9040663, 63)
Show SMILES C[C@@H](OCc1ccccc1)[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C55H75ClN16O10/c1-31(82-30-33-13-4-3-5-14-33)46-53(81)71-43(27-34-15-6-8-17-37(34)56)52(80)68-41(21-12-26-64-55(60)61)49(77)70-44(28-35-29-65-38-18-9-7-16-36(35)38)51(79)67-39(47(57)75)19-10-24-62-45(74)23-22-42(50(78)72-46)69-48(76)40(66-32(2)73)20-11-25-63-54(58)59/h3-9,13-18,29,31,39-44,46,65H,10-12,19-28,30H2,1-2H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,80)(H,69,76)(H,70,77)(H,71,81)(H,72,78)(H4,58,59,63)(H4,60,61,64)/t31-,39+,40+,41+,42+,43-,44+,46+/m1/s1
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0.350 -13.4n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135630
PNG
(US10179804, Example 15 | US8846601, 15 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C56H76N16O10/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-29-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(27-36-30-65-39-19-9-8-18-38(36)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(26-34-14-4-2-5-15-34)70-53(80)46-28-37(31-72(46)54(45)81)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,65H,10-13,20-29,31-32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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0.700 -13.0n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135630
PNG
(US10179804, Example 15 | US8846601, 15 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C56H76N16O10/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-29-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(27-36-30-65-39-19-9-8-18-38(36)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(26-34-14-4-2-5-15-34)70-53(80)46-28-37(31-72(46)54(45)81)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,65H,10-13,20-29,31-32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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0.700n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135630
PNG
(US10179804, Example 15 | US8846601, 15 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C56H76N16O10/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-29-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(27-36-30-65-39-19-9-8-18-38(36)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(26-34-14-4-2-5-15-34)70-53(80)46-28-37(31-72(46)54(45)81)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,65H,10-13,20-29,31-32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Rattus norvegicus)
BDBM50405764
PNG
(CHEMBL264298)
Show SMILES CCNC(=O)C1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C61H75N11O9/c1-4-64-59(79)53-24-14-30-72(53)60(80)48(23-13-29-65-61(62)63)68-55(75)49(31-38(2)3)69-57(77)51(33-43-35-66-47-22-11-10-21-46(43)47)71-56(76)50(32-39-25-27-44(73)28-26-39)70-58(78)52(37-81-36-40-15-6-5-7-16-40)67-54(74)34-42-19-12-18-41-17-8-9-20-45(41)42/h5-12,15-22,25-28,35,38,48-53,66,73H,4,13-14,23-24,29-34,36-37H2,1-3H3,(H,64,79)(H,67,74)(H,68,75)(H,69,77)(H,70,78)(H,71,76)(H4,62,63,65)/t48-,49-,50-,51+,52-,53?/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Abbott Laboratory

Curated by ChEMBL


Assay Description
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilib...


J Med Chem 32: 2340-4 (1989)


Article DOI: 10.1021/jm00130a019
BindingDB Entry DOI: 10.7270/Q2H70H1B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135669
PNG
(US10179804, Example 54 | US8846601, 54 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C56H75N15O11/c1-33(72)65-40(21-12-24-62-55(57)58)48(74)70-45-29-47(73)61-23-11-10-20-42(54(80)81)67-51(77)44(27-36-30-64-39-19-9-8-18-38(36)39)68-49(75)41(22-13-25-63-56(59)60)66-50(76)43(26-34-14-4-2-5-15-34)69-52(78)46-28-37(31-71(46)53(45)79)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,64H,10-13,20-29,31-32H2,1H3,(H,61,73)(H,65,72)(H,66,76)(H,67,77)(H,68,75)(H,69,78)(H,70,74)(H,80,81)(H4,57,58,62)(H4,59,60,63)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3 -12.1n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135669
PNG
(US10179804, Example 54 | US8846601, 54 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C56H75N15O11/c1-33(72)65-40(21-12-24-62-55(57)58)48(74)70-45-29-47(73)61-23-11-10-20-42(54(80)81)67-51(77)44(27-36-30-64-39-19-9-8-18-38(36)39)68-49(75)41(22-13-25-63-56(59)60)66-50(76)43(26-34-14-4-2-5-15-34)69-52(78)46-28-37(31-71(46)53(45)79)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,64H,10-13,20-29,31-32H2,1H3,(H,61,73)(H,65,72)(H,66,76)(H,67,77)(H,68,75)(H,69,78)(H,70,74)(H,80,81)(H4,57,58,62)(H4,59,60,63)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135669
PNG
(US10179804, Example 54 | US8846601, 54 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C56H75N15O11/c1-33(72)65-40(21-12-24-62-55(57)58)48(74)70-45-29-47(73)61-23-11-10-20-42(54(80)81)67-51(77)44(27-36-30-64-39-19-9-8-18-38(36)39)68-49(75)41(22-13-25-63-56(59)60)66-50(76)43(26-34-14-4-2-5-15-34)69-52(78)46-28-37(31-71(46)53(45)79)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,64H,10-13,20-29,31-32H2,1H3,(H,61,73)(H,65,72)(H,66,76)(H,67,77)(H,68,75)(H,69,78)(H,70,74)(H,80,81)(H4,57,58,62)(H4,59,60,63)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Rattus norvegicus)
BDBM50405766
PNG
(CHEMBL386525)
Show SMILES CCNC(=O)C1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12
Show InChI InChI=1S/C62H77N11O9/c1-4-65-60(80)54-24-14-32-73(54)61(81)49(23-13-31-66-62(63)64)69-56(76)50(33-39(2)3)70-58(78)52(35-44-36-67-48-22-11-10-21-47(44)48)72-57(77)51(34-40-25-28-45(74)29-26-40)71-59(79)53(38-82-37-41-15-6-5-7-16-41)68-55(75)30-27-43-19-12-18-42-17-8-9-20-46(42)43/h5-12,15-22,25-26,28-29,36,39,49-54,67,74H,4,13-14,23-24,27,30-35,37-38H2,1-3H3,(H,65,80)(H,68,75)(H,69,76)(H,70,78)(H,71,79)(H,72,77)(H4,63,64,66)/t49-,50-,51-,52+,53-,54?/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Abbott Laboratory

Curated by ChEMBL


Assay Description
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilib...


J Med Chem 32: 2340-4 (1989)


Article DOI: 10.1021/jm00130a019
BindingDB Entry DOI: 10.7270/Q2H70H1B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM160217
PNG
(US9040663, 63)
Show SMILES C[C@@H](OCc1ccccc1)[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C55H75ClN16O10/c1-31(82-30-33-13-4-3-5-14-33)46-53(81)71-43(27-34-15-6-8-17-37(34)56)52(80)68-41(21-12-26-64-55(60)61)49(77)70-44(28-35-29-65-38-18-9-7-16-36(35)38)51(79)67-39(47(57)75)19-10-24-62-45(74)23-22-42(50(78)72-46)69-48(76)40(66-32(2)73)20-11-25-63-54(58)59/h3-9,13-18,29,31,39-44,46,65H,10-12,19-28,30H2,1-2H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,80)(H,69,76)(H,70,77)(H,71,81)(H,72,78)(H4,58,59,63)(H4,60,61,64)/t31-,39+,40+,41+,42+,43-,44+,46+/m1/s1
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12 -11.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM160201
PNG
(US9040663, 47)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@H](COCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73ClN16O10/c1-31(72)65-39(19-10-24-62-53(57)58)47(75)68-41-21-22-45(73)61-23-9-18-38(46(56)74)66-50(78)43(27-34-28-64-37-17-8-6-15-35(34)37)69-48(76)40(20-11-25-63-54(59)60)67-51(79)42(26-33-14-5-7-16-36(33)55)70-52(80)44(71-49(41)77)30-81-29-32-12-3-2-4-13-32/h2-8,12-17,28,38-44,64H,9-11,18-27,29-30H2,1H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,79)(H,68,75)(H,69,76)(H,70,80)(H,71,77)(H4,57,58,62)(H4,59,60,63)/t38-,39-,40-,41-,42+,43-,44-/m0/s1
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25 -10.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135749
PNG
(US8846601, 134)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](COCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C52H72N16O9/c53-35(18-11-23-60-51(55)56)45(71)65-41-27-43(69)59-22-10-9-20-37(44(54)70)63-48(74)40(26-33-28-62-36-19-8-7-17-34(33)36)67-46(72)38(21-12-24-61-52(57)58)64-47(73)39(25-31-13-3-1-4-14-31)66-50(76)42(68-49(41)75)30-77-29-32-15-5-2-6-16-32/h1-8,13-17,19,28,35,37-42,62H,9-12,18,20-27,29-30,53H2,(H2,54,70)(H,59,69)(H,63,74)(H,64,73)(H,65,71)(H,66,76)(H,67,72)(H,68,75)(H4,55,56,60)(H4,57,58,61)/t35-,37-,38-,39+,40-,41-,42-/m0/s1
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30n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
SSTR4


(RAT)
BDBM84642
PNG
(SA IV | c[Ahx-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C44H58N8O6/c1-29(58-28-31-17-8-5-9-18-31)39-44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(25-30-15-6-4-7-16-30)42(55)48-35(41(54)52-39)21-10-2-3-13-23-45/h4-9,11-12,15-20,27,29,35-39,47H,2-3,10,13-14,21-26,28,45-46H2,1H3,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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34n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
SSTR4


(RAT)
BDBM84641
PNG
(SA V | c[Aoc-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C46H62N8O6/c1-31(60-30-33-19-10-7-11-20-33)41-46(59)51-38(24-16-26-48)42(55)53-40(28-34-29-49-36-22-14-13-21-35(34)36)45(58)52-39(27-32-17-8-6-9-18-32)44(57)50-37(43(56)54-41)23-12-4-2-3-5-15-25-47/h6-11,13-14,17-22,29,31,37-41,49H,2-5,12,15-16,23-28,30,47-48H2,1H3,(H,50,57)(H,51,59)(H,52,58)(H,53,55)(H,54,56)
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50n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
SSTR3


(MOUSE)
BDBM84642
PNG
(SA IV | c[Ahx-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C44H58N8O6/c1-29(58-28-31-17-8-5-9-18-31)39-44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(25-30-15-6-4-7-16-30)42(55)48-35(41(54)52-39)21-10-2-3-13-23-45/h4-9,11-12,15-20,27,29,35-39,47H,2-3,10,13-14,21-26,28,45-46H2,1H3,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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73n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM84644
PNG
(III | SA III | c[Aha-Phe-D-Trp-Lys-Ser(Bzl)])
Show SMILES NCCCCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC(=O)C(COCc2ccccc2)NC1=O
Show InChI InChI=1S/C44H58N8O6/c45-23-13-3-1-2-10-21-35-41(54)52-39(29-58-28-31-17-8-5-9-18-31)44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(42(55)48-35)25-30-15-6-4-7-16-30/h4-9,11-12,15-20,27,35-39,47H,1-3,10,13-14,21-26,28-29,45-46H2,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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80n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
SSTR3


(MOUSE)
BDBM84641
PNG
(SA V | c[Aoc-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C46H62N8O6/c1-31(60-30-33-19-10-7-11-20-33)41-46(59)51-38(24-16-26-48)42(55)53-40(28-34-29-49-36-22-14-13-21-35(34)36)45(58)52-39(27-32-17-8-6-9-18-32)44(57)50-37(43(56)54-41)23-12-4-2-3-5-15-25-47/h6-11,13-14,17-22,29,31,37-41,49H,2-5,12,15-16,23-28,30,47-48H2,1H3,(H,50,57)(H,51,59)(H,52,58)(H,53,55)(H,54,56)
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101n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135650
PNG
(US10179804, Example 35 | US8846601, 35 | US9458201...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C48H70N16O10/c1-26(65)39-46(74)63-35(22-28-12-4-3-5-13-28)43(71)60-34(18-11-21-56-48(52)53)42(70)61-36(23-29-25-57-31-15-7-6-14-30(29)31)44(72)59-32(40(49)68)16-8-9-19-54-38(67)24-37(45(73)64-39)62-41(69)33(58-27(2)66)17-10-20-55-47(50)51/h3-7,12-15,25-26,32-37,39,57,65H,8-11,16-24H2,1-2H3,(H2,49,68)(H,54,67)(H,58,66)(H,59,72)(H,60,71)(H,61,70)(H,62,69)(H,63,74)(H,64,73)(H4,50,51,55)(H4,52,53,56)/t26-,32+,33+,34+,35-,36+,37+,39+/m1/s1
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140n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135650
PNG
(US10179804, Example 35 | US8846601, 35 | US9458201...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C48H70N16O10/c1-26(65)39-46(74)63-35(22-28-12-4-3-5-13-28)43(71)60-34(18-11-21-56-48(52)53)42(70)61-36(23-29-25-57-31-15-7-6-14-30(29)31)44(72)59-32(40(49)68)16-8-9-19-54-38(67)24-37(45(73)64-39)62-41(69)33(58-27(2)66)17-10-20-55-47(50)51/h3-7,12-15,25-26,32-37,39,57,65H,8-11,16-24H2,1-2H3,(H2,49,68)(H,54,67)(H,58,66)(H,59,72)(H,60,71)(H,61,70)(H,62,69)(H,63,74)(H,64,73)(H4,50,51,55)(H4,52,53,56)/t26-,32+,33+,34+,35-,36+,37+,39+/m1/s1
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140n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135650
PNG
(US10179804, Example 35 | US8846601, 35 | US9458201...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C48H70N16O10/c1-26(65)39-46(74)63-35(22-28-12-4-3-5-13-28)43(71)60-34(18-11-21-56-48(52)53)42(70)61-36(23-29-25-57-31-15-7-6-14-30(29)31)44(72)59-32(40(49)68)16-8-9-19-54-38(67)24-37(45(73)64-39)62-41(69)33(58-27(2)66)17-10-20-55-47(50)51/h3-7,12-15,25-26,32-37,39,57,65H,8-11,16-24H2,1-2H3,(H2,49,68)(H,54,67)(H,58,66)(H,59,72)(H,60,71)(H,61,70)(H,62,69)(H,63,74)(H,64,73)(H4,50,51,55)(H4,52,53,56)/t26-,32+,33+,34+,35-,36+,37+,39+/m1/s1
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140 -9.72n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172 -9.59n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM84642
PNG
(SA IV | c[Ahx-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C44H58N8O6/c1-29(58-28-31-17-8-5-9-18-31)39-44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(25-30-15-6-4-7-16-30)42(55)48-35(41(54)52-39)21-10-2-3-13-23-45/h4-9,11-12,15-20,27,29,35-39,47H,2-3,10,13-14,21-26,28,45-46H2,1H3,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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183n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
SSTR4


(RAT)
BDBM84644
PNG
(III | SA III | c[Aha-Phe-D-Trp-Lys-Ser(Bzl)])
Show SMILES NCCCCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC(=O)C(COCc2ccccc2)NC1=O
Show InChI InChI=1S/C44H58N8O6/c45-23-13-3-1-2-10-21-35-41(54)52-39(29-58-28-31-17-8-5-9-18-31)44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(42(55)48-35)25-30-15-6-4-7-16-30/h4-9,11-12,15-20,27,35-39,47H,1-3,10,13-14,21-26,28-29,45-46H2,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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188n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
SSTR3


(MOUSE)
BDBM84644
PNG
(III | SA III | c[Aha-Phe-D-Trp-Lys-Ser(Bzl)])
Show SMILES NCCCCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC(=O)C(COCc2ccccc2)NC1=O
Show InChI InChI=1S/C44H58N8O6/c45-23-13-3-1-2-10-21-35-41(54)52-39(29-58-28-31-17-8-5-9-18-31)44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(42(55)48-35)25-30-15-6-4-7-16-30/h4-9,11-12,15-20,27,35-39,47H,1-3,10,13-14,21-26,28-29,45-46H2,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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214n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM84641
PNG
(SA V | c[Aoc-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C46H62N8O6/c1-31(60-30-33-19-10-7-11-20-33)41-46(59)51-38(24-16-26-48)42(55)53-40(28-34-29-49-36-22-14-13-21-35(34)36)45(58)52-39(27-32-17-8-6-9-18-32)44(57)50-37(43(56)54-41)23-12-4-2-3-5-15-25-47/h6-11,13-14,17-22,29,31,37-41,49H,2-5,12,15-16,23-28,30,47-48H2,1H3,(H,50,57)(H,51,59)(H,52,58)(H,53,55)(H,54,56)
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700n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
SSTR2


(MOUSE)
BDBM84641
PNG
(SA V | c[Aoc-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C46H62N8O6/c1-31(60-30-33-19-10-7-11-20-33)41-46(59)51-38(24-16-26-48)42(55)53-40(28-34-29-49-36-22-14-13-21-35(34)36)45(58)52-39(27-32-17-8-6-9-18-32)44(57)50-37(43(56)54-41)23-12-4-2-3-5-15-25-47/h6-11,13-14,17-22,29,31,37-41,49H,2-5,12,15-16,23-28,30,47-48H2,1H3,(H,50,57)(H,51,59)(H,52,58)(H,53,55)(H,54,56)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM84644
PNG
(III | SA III | c[Aha-Phe-D-Trp-Lys-Ser(Bzl)])
Show SMILES NCCCCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC(=O)C(COCc2ccccc2)NC1=O
Show InChI InChI=1S/C44H58N8O6/c45-23-13-3-1-2-10-21-35-41(54)52-39(29-58-28-31-17-8-5-9-18-31)44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(42(55)48-35)25-30-15-6-4-7-16-30/h4-9,11-12,15-20,27,35-39,47H,1-3,10,13-14,21-26,28-29,45-46H2,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM84642
PNG
(SA IV | c[Ahx-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C44H58N8O6/c1-29(58-28-31-17-8-5-9-18-31)39-44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(25-30-15-6-4-7-16-30)42(55)48-35(41(54)52-39)21-10-2-3-13-23-45/h4-9,11-12,15-20,27,29,35-39,47H,2-3,10,13-14,21-26,28,45-46H2,1H3,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM84641
PNG
(SA V | c[Aoc-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C46H62N8O6/c1-31(60-30-33-19-10-7-11-20-33)41-46(59)51-38(24-16-26-48)42(55)53-40(28-34-29-49-36-22-14-13-21-35(34)36)45(58)52-39(27-32-17-8-6-9-18-32)44(57)50-37(43(56)54-41)23-12-4-2-3-5-15-25-47/h6-11,13-14,17-22,29,31,37-41,49H,2-5,12,15-16,23-28,30,47-48H2,1H3,(H,50,57)(H,51,59)(H,52,58)(H,53,55)(H,54,56)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 44: 385-92 (1993)


BindingDB Entry DOI: 10.7270/Q2X065KZ
More data for this
Ligand-Target Pair
SSTR2


(MOUSE)
BDBM84644
PNG
(III | SA III | c[Aha-Phe-D-Trp-Lys-Ser(Bzl)])
Show SMILES NCCCCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC(=O)C(COCc2ccccc2)NC1=O
Show InChI InChI=1S/C44H58N8O6/c45-23-13-3-1-2-10-21-35-41(54)52-39(29-58-28-31-17-8-5-9-18-31)44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(42(55)48-35)25-30-15-6-4-7-16-30/h4-9,11-12,15-20,27,35-39,47H,1-3,10,13-14,21-26,28-29,45-46H2,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
SSTR2


(MOUSE)
BDBM84642
PNG
(SA IV | c[Ahx-Phe-D-Trp-Lys-Thr(Bzl)])
Show SMILES CC(OCc1ccccc1)C1NC(=O)C(CCCCCCN)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CCCN)NC1=O
Show InChI InChI=1S/C44H58N8O6/c1-29(58-28-31-17-8-5-9-18-31)39-44(57)49-36(22-14-24-46)40(53)51-38(26-32-27-47-34-20-12-11-19-33(32)34)43(56)50-37(25-30-15-6-4-7-16-30)42(55)48-35(41(54)52-39)21-10-2-3-13-23-45/h4-9,11-12,15-20,27,29,35-39,47H,2-3,10,13-14,21-26,28,45-46H2,1H3,(H,48,55)(H,49,57)(H,50,56)(H,51,53)(H,52,54)
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1.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by PDSP Ki Database




Mol Pharmacol 43: 838-44 (1993)


BindingDB Entry DOI: 10.7270/Q21N7ZN7
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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US Patent
1.45E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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1.45E+3 -8.28n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
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4.29E+3 -7.61n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
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4.29E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
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4.29E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair