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4 similar compounds to monomer 50260800

Compile data set for download or QSAR
Wt: 290.3
BDBM8476
Wt: 579.3
BDBM50260883
Wt: 477.5
BDBM50260968
Wt: 399.4
BDBM50260802

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8476,50260883,50260968,50260802   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM50260802
PNG
(CHEMBL496717 | N-hydroxy-2,3-bis(phenylsulfonamido...)
Show SMILES ONC(=O)C(CNS(=O)(=O)c1ccccc1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H17N3O6S2/c19-15(17-20)14(18-26(23,24)13-9-5-2-6-10-13)11-16-25(21,22)12-7-3-1-4-8-12/h1-10,14,16,18,20H,11H2,(H,17,19)
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227n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50260802
PNG
(CHEMBL496717 | N-hydroxy-2,3-bis(phenylsulfonamido...)
Show SMILES ONC(=O)C(CNS(=O)(=O)c1ccccc1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H17N3O6S2/c19-15(17-20)14(18-26(23,24)13-9-5-2-6-10-13)11-16-25(21,22)12-7-3-1-4-8-12/h1-10,14,16,18,20H,11H2,(H,17,19)
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356n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50260802
PNG
(CHEMBL496717 | N-hydroxy-2,3-bis(phenylsulfonamido...)
Show SMILES ONC(=O)C(CNS(=O)(=O)c1ccccc1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H17N3O6S2/c19-15(17-20)14(18-26(23,24)13-9-5-2-6-10-13)11-16-25(21,22)12-7-3-1-4-8-12/h1-10,14,16,18,20H,11H2,(H,17,19)
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2.80E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50260968
PNG
((S)-2,6-bis(4-fluorophenylsulfonamido)-N-hydroxyhe...)
Show SMILES ONC(=O)[C@H](CCCCNS(=O)(=O)c1ccc(F)cc1)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C18H21F2N3O6S2/c19-13-4-8-15(9-5-13)30(26,27)21-12-2-1-3-17(18(24)22-25)23-31(28,29)16-10-6-14(20)7-11-16/h4-11,17,21,23,25H,1-3,12H2,(H,22,24)/t17-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50260883
PNG
(CHEMBL494643 | N-hydroxy-2,3-bis(perfluorophenylsu...)
Show SMILES ONC(=O)C(CNS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)NS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C15H7F10N3O6S2/c16-3-5(18)9(22)13(10(23)6(3)19)35(31,32)26-1-2(15(29)27-30)28-36(33,34)14-11(24)7(20)4(17)8(21)12(14)25/h2,26,28,30H,1H2,(H,27,29)
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8.60E+3n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50260883
PNG
(CHEMBL494643 | N-hydroxy-2,3-bis(perfluorophenylsu...)
Show SMILES ONC(=O)C(CNS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)NS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C15H7F10N3O6S2/c16-3-5(18)9(22)13(10(23)6(3)19)35(31,32)26-1-2(15(29)27-30)28-36(33,34)14-11(24)7(20)4(17)8(21)12(14)25/h2,26,28,30H,1H2,(H,27,29)
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2.12E+5n/an/an/an/an/an/an/an/a



North Dakota State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9


Bioorg Med Chem Lett 18: 3333-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.035
BindingDB Entry DOI: 10.7270/Q2SX6D1R
More data for this
Ligand-Target Pair
Anthrax Lethal Factor (LF)


(Bacillus anthracis)
BDBM8476
PNG
((2R)-2-[(4-fluorobenzene)sulfonamido]-N-hydroxy-3-...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C11H15FN2O4S/c1-7(2)10(11(15)13-16)14-19(17,18)9-5-3-8(12)4-6-9/h3-7,10,14,16H,1-2H3,(H,13,15)/t10-/m1/s1
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n/an/a 290n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...


Bioorg Med Chem Lett 16: 964-8 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.088
BindingDB Entry DOI: 10.7270/Q2K35RV4
More data for this
Ligand-Target Pair