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285 similar compounds to monomer 135752

Compile data set for download or QSAR
Wt: 1012.1
BDBM85191
Wt: 989.1
BDBM135619
Wt: 1002.1
BDBM135620
Wt: 1030.2
BDBM135622
Wt: 973.1
BDBM135623
Wt: 1077.2
BDBM135625
Wt: 1093.2
BDBM135626
Wt: 1043.2
BDBM135627
Wt: 1043.2
BDBM135628
Wt: 1029.1
BDBM135631
Wt: 1117.3
BDBM135633
Wt: 1086.2
BDBM135643
Wt: 1001.1
BDBM135624
Wt: 1058.2
BDBM135617
Wt: 1017.1
BDBM135618
Displayed 1 to 15 (of 284 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 85191,135617,135618,135619,135620,135622,135623,135624,135625,135626,135627,135628,135631,135633,135643   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM85191
PNG
(Ac-RYYRWK-NH2 | CAS_200959-47-3)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C49H69N15O9/c1-28(65)59-37(11-6-22-56-48(52)53)43(69)62-40(25-30-15-19-33(67)20-16-30)46(72)63-39(24-29-13-17-32(66)18-14-29)45(71)61-38(12-7-23-57-49(54)55)44(70)64-41(26-31-27-58-35-9-3-2-8-34(31)35)47(73)60-36(42(51)68)10-4-5-21-50/h2-3,8-9,13-20,27,36-41,58,66-67H,4-7,10-12,21-26,50H2,1H3,(H2,51,68)(H,59,65)(H,60,73)(H,61,71)(H,62,69)(H,63,72)(H,64,70)(H4,52,53,56)(H4,54,55,57)/t36-,37-,38-,39-,40-,41-/m0/s1
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Article
PubMed
0.710n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by PDSP Ki Database




J Pharmacol Exp Ther 283: 735-41 (1997)


Article DOI: 10.1016/j.chembiol.2014.12.015
BindingDB Entry DOI: 10.7270/Q2JW8CDH
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US10179804, Example 18 | US8846601, 18 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US10179804, Example 18 | US8846601, 18 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US10179804, Example 18 | US8846601, 18 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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3 -12.1n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135643
PNG
(US10179804, Example 28 | US8846601, 28 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(17-9-21-59-48(52)53)42(73)69-39-26-40(71)58-20-8-7-16-33(41(51)72)64-46(77)38(25-30-27-62-32-15-6-5-14-31(30)32)68-44(75)36(19-11-23-61-50(56)57)65-45(76)37(24-29-12-3-2-4-13-29)67-43(74)35(66-47(39)78)18-10-22-60-49(54)55/h2-6,12-15,27,33-39,62H,7-11,16-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,77)(H,65,76)(H,66,78)(H,67,74)(H,68,75)(H,69,73)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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4 -11.9n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135643
PNG
(US10179804, Example 28 | US8846601, 28 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(17-9-21-59-48(52)53)42(73)69-39-26-40(71)58-20-8-7-16-33(41(51)72)64-46(77)38(25-30-27-62-32-15-6-5-14-31(30)32)68-44(75)36(19-11-23-61-50(56)57)65-45(76)37(24-29-12-3-2-4-13-29)67-43(74)35(66-47(39)78)18-10-22-60-49(54)55/h2-6,12-15,27,33-39,62H,7-11,16-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,77)(H,65,76)(H,66,78)(H,67,74)(H,68,75)(H,69,73)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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4n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135643
PNG
(US10179804, Example 28 | US8846601, 28 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(17-9-21-59-48(52)53)42(73)69-39-26-40(71)58-20-8-7-16-33(41(51)72)64-46(77)38(25-30-27-62-32-15-6-5-14-31(30)32)68-44(75)36(19-11-23-61-50(56)57)65-45(76)37(24-29-12-3-2-4-13-29)67-43(74)35(66-47(39)78)18-10-22-60-49(54)55/h2-6,12-15,27,33-39,62H,7-11,16-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,77)(H,65,76)(H,66,78)(H,67,74)(H,68,75)(H,69,73)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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4n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US10179804, Example 18 | US8846601, 18 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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12 -11.2n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US10179804, Example 9 | US8846601, 52 | US8846601,...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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19n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US10179804, Example 9 | US8846601, 52 | US8846601,...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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19 -10.9n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US10179804, Example 9 | US8846601, 52 | US8846601,...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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19n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135631
PNG
(US10179804, Example 16 | US8846601, 16 | US9458201...)
Show SMILES CC(C)C1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H72N16O9/c1-27(2)40-47(74)64-36(23-29-13-5-4-6-14-29)44(71)61-35(19-12-22-57-49(53)54)43(70)62-37(24-30-26-58-32-16-8-7-15-31(30)32)45(72)60-33(41(50)68)17-9-10-20-55-39(67)25-38(46(73)65-40)63-42(69)34(59-28(3)66)18-11-21-56-48(51)52/h4-8,13-16,26-27,33-38,40,58H,9-12,17-25H2,1-3H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,70)(H,63,69)(H,64,74)(H,65,73)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,40?/m0/s1
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23n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135631
PNG
(US10179804, Example 16 | US8846601, 16 | US9458201...)
Show SMILES CC(C)C1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H72N16O9/c1-27(2)40-47(74)64-36(23-29-13-5-4-6-14-29)44(71)61-35(19-12-22-57-49(53)54)43(70)62-37(24-30-26-58-32-16-8-7-15-31(30)32)45(72)60-33(41(50)68)17-9-10-20-55-39(67)25-38(46(73)65-40)63-42(69)34(59-28(3)66)18-11-21-56-48(51)52/h4-8,13-16,26-27,33-38,40,58H,9-12,17-25H2,1-3H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,70)(H,63,69)(H,64,74)(H,65,73)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,40?/m0/s1
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23 -10.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135631
PNG
(US10179804, Example 16 | US8846601, 16 | US9458201...)
Show SMILES CC(C)C1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H72N16O9/c1-27(2)40-47(74)64-36(23-29-13-5-4-6-14-29)44(71)61-35(19-12-22-57-49(53)54)43(70)62-37(24-30-26-58-32-16-8-7-15-31(30)32)45(72)60-33(41(50)68)17-9-10-20-55-39(67)25-38(46(73)65-40)63-42(69)34(59-28(3)66)18-11-21-56-48(51)52/h4-8,13-16,26-27,33-38,40,58H,9-12,17-25H2,1-3H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,70)(H,63,69)(H,64,74)(H,65,73)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,40?/m0/s1
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23n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US10179804, Example 2 | US8846601, 116 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US10179804, Example 2 | US8846601, 116 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30 -10.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135628
PNG
(US10179804, Example 13 | US8846601, 13 | US9458201...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-3-4-17-36-44(71)64-38(25-30-14-6-5-7-15-30)46(73)63-37(21-13-24-58-50(54)55)45(72)65-39(26-31-28-59-33-18-9-8-16-32(31)33)47(74)61-34(42(51)69)19-10-11-22-56-41(68)27-40(48(75)62-36)66-43(70)35(60-29(2)67)20-12-23-57-49(52)53/h5-9,14-16,18,28,34-40,59H,3-4,10-13,17,19-27H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,73)(H,64,71)(H,65,72)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30 -10.7n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135628
PNG
(US10179804, Example 13 | US8846601, 13 | US9458201...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-3-4-17-36-44(71)64-38(25-30-14-6-5-7-15-30)46(73)63-37(21-13-24-58-50(54)55)45(72)65-39(26-31-28-59-33-18-9-8-16-32(31)33)47(74)61-34(42(51)69)19-10-11-22-56-41(68)27-40(48(75)62-36)66-43(70)35(60-29(2)67)20-12-23-57-49(52)53/h5-9,14-16,18,28,34-40,59H,3-4,10-13,17,19-27H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,73)(H,64,71)(H,65,72)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135628
PNG
(US10179804, Example 13 | US8846601, 13 | US9458201...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-3-4-17-36-44(71)64-38(25-30-14-6-5-7-15-30)46(73)63-37(21-13-24-58-50(54)55)45(72)65-39(26-31-28-59-33-18-9-8-16-32(31)33)47(74)61-34(42(51)69)19-10-11-22-56-41(68)27-40(48(75)62-36)66-43(70)35(60-29(2)67)20-12-23-57-49(52)53/h5-9,14-16,18,28,34-40,59H,3-4,10-13,17,19-27H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,73)(H,64,71)(H,65,72)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US10179804, Example 2 | US8846601, 116 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135627
PNG
(US10179804, Example 12 | US8846601, 12 | US9458201...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-28(2)23-37-45(72)64-38(24-30-13-5-4-6-14-30)46(73)62-36(19-12-22-58-50(54)55)44(71)65-39(25-31-27-59-33-16-8-7-15-32(31)33)47(74)61-34(42(51)69)17-9-10-20-56-41(68)26-40(48(75)63-37)66-43(70)35(60-29(3)67)18-11-21-57-49(52)53/h4-8,13-16,27-28,34-40,59H,9-12,17-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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33n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135627
PNG
(US10179804, Example 12 | US8846601, 12 | US9458201...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-28(2)23-37-45(72)64-38(24-30-13-5-4-6-14-30)46(73)62-36(19-12-22-58-50(54)55)44(71)65-39(25-31-27-59-33-16-8-7-15-32(31)33)47(74)61-34(42(51)69)17-9-10-20-56-41(68)26-40(48(75)63-37)66-43(70)35(60-29(3)67)18-11-21-57-49(52)53/h4-8,13-16,27-28,34-40,59H,9-12,17-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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33n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135627
PNG
(US10179804, Example 12 | US8846601, 12 | US9458201...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-28(2)23-37-45(72)64-38(24-30-13-5-4-6-14-30)46(73)62-36(19-12-22-58-50(54)55)44(71)65-39(25-31-27-59-33-16-8-7-15-32(31)33)47(74)61-34(42(51)69)17-9-10-20-56-41(68)26-40(48(75)63-37)66-43(70)35(60-29(3)67)18-11-21-57-49(52)53/h4-8,13-16,27-28,34-40,59H,9-12,17-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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33 -10.6n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135626
PNG
(US10179804, Example 11 | US8846601, 11 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O10/c1-30(70)63-38(16-9-23-60-52(55)56)46(74)69-43-28-44(72)59-22-8-7-15-37(45(54)73)64-50(78)42(27-33-29-62-36-14-6-5-13-35(33)36)68-47(75)39(17-10-24-61-53(57)58)65-48(76)40(25-31-11-3-2-4-12-31)66-49(77)41(67-51(43)79)26-32-18-20-34(71)21-19-32/h2-6,11-14,18-21,29,37-43,62,71H,7-10,15-17,22-28H2,1H3,(H2,54,73)(H,59,72)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,79)(H,68,75)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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43n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135626
PNG
(US10179804, Example 11 | US8846601, 11 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O10/c1-30(70)63-38(16-9-23-60-52(55)56)46(74)69-43-28-44(72)59-22-8-7-15-37(45(54)73)64-50(78)42(27-33-29-62-36-14-6-5-13-35(33)36)68-47(75)39(17-10-24-61-53(57)58)65-48(76)40(25-31-11-3-2-4-12-31)66-49(77)41(67-51(43)79)26-32-18-20-34(71)21-19-32/h2-6,11-14,18-21,29,37-43,62,71H,7-10,15-17,22-28H2,1H3,(H2,54,73)(H,59,72)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,79)(H,68,75)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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43 -10.4n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135626
PNG
(US10179804, Example 11 | US8846601, 11 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O10/c1-30(70)63-38(16-9-23-60-52(55)56)46(74)69-43-28-44(72)59-22-8-7-15-37(45(54)73)64-50(78)42(27-33-29-62-36-14-6-5-13-35(33)36)68-47(75)39(17-10-24-61-53(57)58)65-48(76)40(25-31-11-3-2-4-12-31)66-49(77)41(67-51(43)79)26-32-18-20-34(71)21-19-32/h2-6,11-14,18-21,29,37-43,62,71H,7-10,15-17,22-28H2,1H3,(H2,54,73)(H,59,72)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,79)(H,68,75)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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43n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135625
PNG
(US10179804, Example 10 | US8846601, 10 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O9/c1-31(70)63-38(21-12-24-60-52(55)56)46(73)69-43-29-44(71)59-23-11-10-20-37(45(54)72)64-50(77)42(28-34-30-62-36-19-9-8-18-35(34)36)68-47(74)39(22-13-25-61-53(57)58)65-48(75)40(26-32-14-4-2-5-15-32)66-49(76)41(67-51(43)78)27-33-16-6-3-7-17-33/h2-9,14-19,30,37-43,62H,10-13,20-29H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,75)(H,66,76)(H,67,78)(H,68,74)(H,69,73)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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51n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135625
PNG
(US10179804, Example 10 | US8846601, 10 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O9/c1-31(70)63-38(21-12-24-60-52(55)56)46(73)69-43-29-44(71)59-23-11-10-20-37(45(54)72)64-50(77)42(28-34-30-62-36-19-9-8-18-35(34)36)68-47(74)39(22-13-25-61-53(57)58)65-48(75)40(26-32-14-4-2-5-15-32)66-49(76)41(67-51(43)78)27-33-16-6-3-7-17-33/h2-9,14-19,30,37-43,62H,10-13,20-29H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,75)(H,66,76)(H,67,78)(H,68,74)(H,69,73)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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51 -10.3n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135625
PNG
(US10179804, Example 10 | US8846601, 10 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O9/c1-31(70)63-38(21-12-24-60-52(55)56)46(73)69-43-29-44(71)59-23-11-10-20-37(45(54)72)64-50(77)42(28-34-30-62-36-19-9-8-18-35(34)36)68-47(74)39(22-13-25-61-53(57)58)65-48(75)40(26-32-14-4-2-5-15-32)66-49(76)41(67-51(43)78)27-33-16-6-3-7-17-33/h2-9,14-19,30,37-43,62H,10-13,20-29H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,75)(H,66,76)(H,67,78)(H,68,74)(H,69,73)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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51n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US10179804, Example 9 | US8846601, 52 | US8846601,...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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144n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US10179804, Example 9 | US8846601, 52 | US8846601,...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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144 -9.70n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172 -9.59n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US10179804, Example 2 | US8846601, 116 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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873n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US10179804, Example 2 | US8846601, 116 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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873 -8.59n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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1.45E+3 -8.28n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US10179804, Example 3 | US8846601, 117 | US8846601...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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1.45E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135620
PNG
(US10179804, Example 5 | US8846601, 5 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H67N15O10/c1-26-40(66)60-35(22-28-12-4-3-5-13-28)44(70)59-34(18-11-21-54-47(51)72)42(68)61-36(23-29-25-55-31-15-7-6-14-30(29)31)45(71)58-32(39(48)65)16-8-9-19-52-38(64)24-37(43(69)56-26)62-41(67)33(57-27(2)63)17-10-20-53-46(49)50/h3-7,12-15,25-26,32-37,55H,8-11,16-24H2,1-2H3,(H2,48,65)(H,52,64)(H,56,69)(H,57,63)(H,58,71)(H,59,70)(H,60,66)(H,61,68)(H,62,67)(H4,49,50,53)(H3,51,54,72)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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2.05E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135620
PNG
(US10179804, Example 5 | US8846601, 5 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H67N15O10/c1-26-40(66)60-35(22-28-12-4-3-5-13-28)44(70)59-34(18-11-21-54-47(51)72)42(68)61-36(23-29-25-55-31-15-7-6-14-30(29)31)45(71)58-32(39(48)65)16-8-9-19-52-38(64)24-37(43(69)56-26)62-41(67)33(57-27(2)63)17-10-20-53-46(49)50/h3-7,12-15,25-26,32-37,55H,8-11,16-24H2,1-2H3,(H2,48,65)(H,52,64)(H,56,69)(H,57,63)(H,58,71)(H,59,70)(H,60,66)(H,61,68)(H,62,67)(H4,49,50,53)(H3,51,54,72)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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2.05E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135620
PNG
(US10179804, Example 5 | US8846601, 5 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H67N15O10/c1-26-40(66)60-35(22-28-12-4-3-5-13-28)44(70)59-34(18-11-21-54-47(51)72)42(68)61-36(23-29-25-55-31-15-7-6-14-30(29)31)45(71)58-32(39(48)65)16-8-9-19-52-38(64)24-37(43(69)56-26)62-41(67)33(57-27(2)63)17-10-20-53-46(49)50/h3-7,12-15,25-26,32-37,55H,8-11,16-24H2,1-2H3,(H2,48,65)(H,52,64)(H,56,69)(H,57,63)(H,58,71)(H,59,70)(H,60,66)(H,61,68)(H,62,67)(H4,49,50,53)(H3,51,54,72)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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2.05E+3 -8.07n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135622
PNG
(US10179804, Example 7 | US8846601, 7 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N15O9/c1-30(66)59-36(21-13-25-57-50(54)55)44(69)65-41-28-42(67)56-24-12-9-18-35(43(53)68)60-48(73)40(27-32-29-58-34-17-6-5-16-33(32)34)64-46(71)38(20-8-11-23-52)61-47(72)39(26-31-14-3-2-4-15-31)63-45(70)37(62-49(41)74)19-7-10-22-51/h2-6,14-17,29,35-41,58H,7-13,18-28,51-52H2,1H3,(H2,53,68)(H,56,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,70)(H,64,71)(H,65,69)(H4,54,55,57)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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2.96E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135622
PNG
(US10179804, Example 7 | US8846601, 7 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N15O9/c1-30(66)59-36(21-13-25-57-50(54)55)44(69)65-41-28-42(67)56-24-12-9-18-35(43(53)68)60-48(73)40(27-32-29-58-34-17-6-5-16-33(32)34)64-46(71)38(20-8-11-23-52)61-47(72)39(26-31-14-3-2-4-15-31)63-45(70)37(62-49(41)74)19-7-10-22-51/h2-6,14-17,29,35-41,58H,7-13,18-28,51-52H2,1H3,(H2,53,68)(H,56,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,70)(H,64,71)(H,65,69)(H4,54,55,57)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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2.96E+3 -7.84n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135622
PNG
(US10179804, Example 7 | US8846601, 7 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N15O9/c1-30(66)59-36(21-13-25-57-50(54)55)44(69)65-41-28-42(67)56-24-12-9-18-35(43(53)68)60-48(73)40(27-32-29-58-34-17-6-5-16-33(32)34)64-46(71)38(20-8-11-23-52)61-47(72)39(26-31-14-3-2-4-15-31)63-45(70)37(62-49(41)74)19-7-10-22-51/h2-6,14-17,29,35-41,58H,7-13,18-28,51-52H2,1H3,(H2,53,68)(H,56,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,70)(H,64,71)(H,65,69)(H4,54,55,57)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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2.96E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135623
PNG
(US10179804, Example 8 | US8846601, 8 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N14O9/c1-27-41(65)59-36(23-29-13-4-3-5-14-29)45(69)58-35(18-8-10-20-48)43(67)60-37(24-30-26-54-32-16-7-6-15-31(30)32)46(70)57-33(40(49)64)17-9-11-21-52-39(63)25-38(44(68)55-27)61-42(66)34(56-28(2)62)19-12-22-53-47(50)51/h3-7,13-16,26-27,33-38,54H,8-12,17-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,68)(H,56,62)(H,57,70)(H,58,69)(H,59,65)(H,60,67)(H,61,66)(H4,50,51,53)/t27-,33-,34-,35-,36+,37-,38-/m0/s1
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3.02E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135623
PNG
(US10179804, Example 8 | US8846601, 8 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N14O9/c1-27-41(65)59-36(23-29-13-4-3-5-14-29)45(69)58-35(18-8-10-20-48)43(67)60-37(24-30-26-54-32-16-7-6-15-31(30)32)46(70)57-33(40(49)64)17-9-11-21-52-39(63)25-38(44(68)55-27)61-42(66)34(56-28(2)62)19-12-22-53-47(50)51/h3-7,13-16,26-27,33-38,54H,8-12,17-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,68)(H,56,62)(H,57,70)(H,58,69)(H,59,65)(H,60,67)(H,61,66)(H4,50,51,53)/t27-,33-,34-,35-,36+,37-,38-/m0/s1
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3.02E+3 -7.83n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135623
PNG
(US10179804, Example 8 | US8846601, 8 | US9458201, ...)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N14O9/c1-27-41(65)59-36(23-29-13-4-3-5-14-29)45(69)58-35(18-8-10-20-48)43(67)60-37(24-30-26-54-32-16-7-6-15-31(30)32)46(70)57-33(40(49)64)17-9-11-21-52-39(63)25-38(44(68)55-27)61-42(66)34(56-28(2)62)19-12-22-53-47(50)51/h3-7,13-16,26-27,33-38,54H,8-12,17-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,68)(H,56,62)(H,57,70)(H,58,69)(H,59,65)(H,60,67)(H,61,66)(H4,50,51,53)/t27-,33-,34-,35-,36+,37-,38-/m0/s1
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3.02E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
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US Patent
4.29E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
KEGG

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
4.29E+3 -7.61n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US10179804, Example 4 | US8846601, 4 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
4.29E+3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair