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286 similar compounds to monomer 50114080

Compile data set for download or QSAR
Wt: 1133.3
BDBM86502
Wt: 1521.7
BDBM85479
Wt: 1101.3
BDBM85480
Wt: 1040.2
BDBM85482
Wt: 1117.3
BDBM85488
Wt: 1024.1
BDBM85490
Wt: 956.1
BDBM85494
Wt: 998.1
BDBM85495
Wt: 1039.1
BDBM135621
Wt: 1068.1
BDBM135668
Wt: 1081.2
BDBM135675
Wt: 1067.2
BDBM135679
Wt: 1117.2
BDBM135634
Wt: 1067.2
BDBM135656
Wt: 1067.2
BDBM135616
Displayed 1 to 15 (of 286 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 58 hits for monomerid = 85479,85480,85482,85488,85490,85494,85495,86502,135616,135621,135634,135656,135668,135675,135679   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gastrin releasing peptide receptor


(MOUSE)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.110n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Gastrin releasing peptide receptor


(MOUSE)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Gastrin releasing peptide receptor


(MOUSE)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.240n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Gastrin releasing peptide receptor


(MOUSE)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.260n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
NMB


(RAT)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.360n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.410n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(Homo sapiens (Human))
BDBM86502
PNG
(CAS_0 | NSC_0 | [D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O11/c1-5-6-15-42(50(60)75)67-55(80)44(26-34-12-8-7-9-13-34)69-56(81)46(28-37-30-61-31-64-37)66-48(74)23-24-62-57(82)49(32(2)3)71-51(76)33(4)65-54(79)45(27-36-29-63-41-16-11-10-14-39(36)41)70-53(78)43(21-22-47(59)73)68-52(77)40(58)25-35-17-19-38(72)20-18-35/h7-14,16-20,29-33,40,42-46,49,63,72H,5-6,15,21-28,58H2,1-4H3,(H2,59,73)(H2,60,75)(H,61,64)(H,62,82)(H,65,79)(H,66,74)(H,67,80)(H,68,77)(H,69,81)(H,70,78)(H,71,76)/t33-,40+,42-,43-,44-,45-,46-,49-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 1161-70 (2004)


Article DOI: 10.1124/jpet.104.066761
BindingDB Entry DOI: 10.7270/Q2513WSQ
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85480
PNG
((3-Ph-Pr6)His7,DAla11,DPro13,Psi13-14,Phe14-Bn(6-1...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1CN[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C57H76N14O9/c1-33(2)49(56(79)66-34(3)51(74)69-47(28-39-30-61-32-64-39)57(80)71-25-13-18-40(71)31-63-45(50(60)73)26-37-16-9-6-10-17-37)70-52(75)35(4)65-55(78)46(27-38-29-62-43-20-12-11-19-41(38)43)68-54(77)44(23-24-48(59)72)67-53(76)42(58)22-21-36-14-7-5-8-15-36/h5-12,14-17,19-20,29-30,32-35,40,42,44-47,49,62-63H,13,18,21-28,31,58H2,1-4H3,(H2,59,72)(H2,60,73)(H,61,64)(H,65,78)(H,66,79)(H,67,76)(H,68,77)(H,69,74)(H,70,75)/t34-,35-,40-,42+,44-,45-,46-,47-,49-/m0/s1
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0.740n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
BRS3


(Homo sapiens (Human))
BDBM86502
PNG
(CAS_0 | NSC_0 | [D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O11/c1-5-6-15-42(50(60)75)67-55(80)44(26-34-12-8-7-9-13-34)69-56(81)46(28-37-30-61-31-64-37)66-48(74)23-24-62-57(82)49(32(2)3)71-51(76)33(4)65-54(79)45(27-36-29-63-41-16-11-10-14-39(36)41)70-53(78)43(21-22-47(59)73)68-52(77)40(58)25-35-17-19-38(72)20-18-35/h7-14,16-20,29-33,40,42-46,49,63,72H,5-6,15,21-28,58H2,1-4H3,(H2,59,73)(H2,60,75)(H,61,64)(H,62,82)(H,65,79)(H,66,74)(H,67,80)(H,68,77)(H,69,81)(H,70,78)(H,71,76)/t33-,40+,42-,43-,44-,45-,46-,49-/m0/s1
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0.820n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 1161-70 (2004)


Article DOI: 10.1124/jpet.104.066761
BindingDB Entry DOI: 10.7270/Q2513WSQ
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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0.990n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135679
PNG
(US10179804, Example 64 | US8846601, 64 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-20-58-49(52)53)43(72)65-37-17-18-41(70)57-19-7-14-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)36(16-9-21-59-50(54)55)64-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(37)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,72)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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US Patent
1n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135679
PNG
(US10179804, Example 64 | US8846601, 64 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-20-58-49(52)53)43(72)65-37-17-18-41(70)57-19-7-14-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)36(16-9-21-59-50(54)55)64-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(37)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,72)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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1 -12.8n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135679
PNG
(US10179804, Example 64 | US8846601, 64 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-20-58-49(52)53)43(72)65-37-17-18-41(70)57-19-7-14-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)36(16-9-21-59-50(54)55)64-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(37)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,72)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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1n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135634
PNG
(US10179804, Example 19 | US8846601, 19 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H72N18O9/c1-30(73)66-39(18-9-21-62-53(56)57)47(76)72-44-26-45(74)61-20-7-6-17-38(46(55)75)67-49(78)42(24-33-27-64-37-16-5-4-15-36(33)37)69-48(77)40(19-10-22-63-54(58)59)68-50(79)41(23-32-13-8-12-31-11-2-3-14-35(31)32)70-51(80)43(71-52(44)81)25-34-28-60-29-65-34/h2-5,8,11-16,27-29,38-44,64H,6-7,9-10,17-26H2,1H3,(H2,55,75)(H,60,65)(H,61,74)(H,66,73)(H,67,78)(H,68,79)(H,69,77)(H,70,80)(H,71,81)(H,72,76)(H4,56,57,62)(H4,58,59,63)/t38-,39-,40-,41+,42-,43-,44-/m0/s1
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3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135634
PNG
(US10179804, Example 19 | US8846601, 19 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H72N18O9/c1-30(73)66-39(18-9-21-62-53(56)57)47(76)72-44-26-45(74)61-20-7-6-17-38(46(55)75)67-49(78)42(24-33-27-64-37-16-5-4-15-36(33)37)69-48(77)40(19-10-22-63-54(58)59)68-50(79)41(23-32-13-8-12-31-11-2-3-14-35(31)32)70-51(80)43(71-52(44)81)25-34-28-60-29-65-34/h2-5,8,11-16,27-29,38-44,64H,6-7,9-10,17-26H2,1H3,(H2,55,75)(H,60,65)(H,61,74)(H,66,73)(H,67,78)(H,68,79)(H,69,77)(H,70,80)(H,71,81)(H,72,76)(H4,56,57,62)(H4,58,59,63)/t38-,39-,40-,41+,42-,43-,44-/m0/s1
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3 -12.1n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135634
PNG
(US10179804, Example 19 | US8846601, 19 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H72N18O9/c1-30(73)66-39(18-9-21-62-53(56)57)47(76)72-44-26-45(74)61-20-7-6-17-38(46(55)75)67-49(78)42(24-33-27-64-37-16-5-4-15-36(33)37)69-48(77)40(19-10-22-63-54(58)59)68-50(79)41(23-32-13-8-12-31-11-2-3-14-35(31)32)70-51(80)43(71-52(44)81)25-34-28-60-29-65-34/h2-5,8,11-16,27-29,38-44,64H,6-7,9-10,17-26H2,1H3,(H2,55,75)(H,60,65)(H,61,74)(H,66,73)(H,67,78)(H,68,79)(H,69,77)(H,70,80)(H,71,81)(H,72,76)(H4,56,57,62)(H4,58,59,63)/t38-,39-,40-,41+,42-,43-,44-/m0/s1
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3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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5n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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5 -11.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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5n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Neuromedin B


(Homo sapiens (Human))
BDBM86502
PNG
(CAS_0 | NSC_0 | [D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O11/c1-5-6-15-42(50(60)75)67-55(80)44(26-34-12-8-7-9-13-34)69-56(81)46(28-37-30-61-31-64-37)66-48(74)23-24-62-57(82)49(32(2)3)71-51(76)33(4)65-54(79)45(27-36-29-63-41-16-11-10-14-39(36)41)70-53(78)43(21-22-47(59)73)68-52(77)40(58)25-35-17-19-38(72)20-18-35/h7-14,16-20,29-33,40,42-46,49,63,72H,5-6,15,21-28,58H2,1-4H3,(H2,59,73)(H2,60,75)(H,61,64)(H,62,82)(H,65,79)(H,66,74)(H,67,80)(H,68,77)(H,69,81)(H,70,78)(H,71,76)/t33-,40+,42-,43-,44-,45-,46-,49-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




J Pharmacol Exp Ther 310: 1161-70 (2004)


Article DOI: 10.1124/jpet.104.066761
BindingDB Entry DOI: 10.7270/Q2513WSQ
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85495
PNG
(DPhe6-Bn(6-13)propylamide)
Show SMILES CCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H71N13O9/c1-7-19-54-46(68)38(20-28(2)3)61-49(71)40(23-33-25-53-27-57-33)59-42(65)26-56-50(72)43(29(4)5)63-44(66)30(6)58-48(70)39(22-32-24-55-36-16-12-11-15-34(32)36)62-47(69)37(17-18-41(52)64)60-45(67)35(51)21-31-13-9-8-10-14-31/h8-16,24-25,27-30,35,37-40,43,55H,7,17-23,26,51H2,1-6H3,(H2,52,64)(H,53,57)(H,54,68)(H,56,72)(H,58,70)(H,59,65)(H,60,67)(H,61,71)(H,62,69)(H,63,66)/t30-,35+,37-,38-,39-,40-,43-/m0/s1
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6n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
BRS3


(Homo sapiens (Human))
BDBM85488
PNG
(DPhe6,BetaAla11,Phe13,Nle14-Bn(6-14))
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C57H76N14O10/c1-6-7-21-42(49(60)73)66-55(79)44(26-36-18-12-9-13-19-36)69-56(80)46(28-38-30-61-31-63-38)68-50(74)33(4)65-57(81)48(32(2)3)71-51(75)34(5)64-54(78)45(27-37-29-62-41-22-15-14-20-39(37)41)70-53(77)43(23-24-47(59)72)67-52(76)40(58)25-35-16-10-8-11-17-35/h8-20,22,29-34,40,42-46,48,62H,6-7,21,23-28,58H2,1-5H3,(H2,59,72)(H2,60,73)(H,61,63)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,74)(H,69,80)(H,70,77)(H,71,75)/t33-,34-,40+,42-,43-,44-,45-,46-,48-/m0/s1
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8.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85482
PNG
(DPhe6-Bn(6-13)hexylamide)
Show SMILES CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C53H77N13O9/c1-7-8-9-15-22-57-49(71)41(23-31(2)3)64-52(74)43(26-36-28-56-30-60-36)62-45(68)29-59-53(75)46(32(4)5)66-47(69)33(6)61-51(73)42(25-35-27-58-39-19-14-13-18-37(35)39)65-50(72)40(20-21-44(55)67)63-48(70)38(54)24-34-16-11-10-12-17-34/h10-14,16-19,27-28,30-33,38,40-43,46,58H,7-9,15,20-26,29,54H2,1-6H3,(H2,55,67)(H,56,60)(H,57,71)(H,59,75)(H,61,73)(H,62,68)(H,63,70)(H,64,74)(H,65,72)(H,66,69)/t33-,38+,40-,41-,42-,43-,46-/m0/s1
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18n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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22 -10.9n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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22n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85494
PNG
(DPhe6-Bn(6-13)NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C47H65N13O9/c1-25(2)17-35(41(50)63)58-46(68)37(20-30-22-51-24-54-30)56-39(62)23-53-47(69)40(26(3)4)60-42(64)27(5)55-45(67)36(19-29-21-52-33-14-10-9-13-31(29)33)59-44(66)34(15-16-38(49)61)57-43(65)32(48)18-28-11-7-6-8-12-28/h6-14,21-22,24-27,32,34-37,40,52H,15-20,23,48H2,1-5H3,(H2,49,61)(H2,50,63)(H,51,54)(H,53,69)(H,55,67)(H,56,62)(H,57,65)(H,58,68)(H,59,66)(H,60,64)/t27-,32+,34-,35-,36-,37-,40-/m0/s1
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27n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85490
PNG
(DPhe6,Leu13,Psi(CH2NH),Cpa14-Bn(6-14))
Show SMILES CC(C)C[C@@H](CN[C@@H](C#N)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H69N15O9/c1-27(2)17-33(24-57-40(21-51)44(54)68)61-49(73)39(20-32-23-55-26-59-32)62-42(67)25-58-50(74)43(28(3)4)65-45(69)29(5)60-48(72)38(19-31-22-56-36-14-10-9-13-34(31)36)64-47(71)37(15-16-41(53)66)63-46(70)35(52)18-30-11-7-6-8-12-30/h6-14,22-23,26-29,33,35,37-40,43,56-57H,15-20,24-25,52H2,1-5H3,(H2,53,66)(H2,54,68)(H,55,59)(H,58,74)(H,60,72)(H,61,73)(H,62,67)(H,63,70)(H,64,71)(H,65,69)/t29-,33-,35+,37-,38-,39-,40-,43-/m0/s1
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42n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135675
PNG
(US10179804, Example 60 | US8846601, 60 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C51H72N18O9/c1-29(70)63-36(17-10-20-59-49(53)54)43(73)67-40-24-41(71)58-19-9-8-16-35(42(52)72)64-45(75)38(22-31-26-61-34-15-7-6-14-33(31)34)65-44(74)37(18-11-21-60-50(55)56)68-48(78)51(2,25-30-12-4-3-5-13-30)69-47(77)39(66-46(40)76)23-32-27-57-28-62-32/h3-7,12-15,26-28,35-40,61H,8-11,16-25H2,1-2H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,75)(H,65,74)(H,66,76)(H,67,73)(H,68,78)(H,69,77)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40-,51+/m0/s1
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47n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135675
PNG
(US10179804, Example 60 | US8846601, 60 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C51H72N18O9/c1-29(70)63-36(17-10-20-59-49(53)54)43(73)67-40-24-41(71)58-19-9-8-16-35(42(52)72)64-45(75)38(22-31-26-61-34-15-7-6-14-33(31)34)65-44(74)37(18-11-21-60-50(55)56)68-48(78)51(2,25-30-12-4-3-5-13-30)69-47(77)39(66-46(40)76)23-32-27-57-28-62-32/h3-7,12-15,26-28,35-40,61H,8-11,16-25H2,1-2H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,75)(H,65,74)(H,66,76)(H,67,73)(H,68,78)(H,69,77)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40-,51+/m0/s1
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47 -10.4n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135675
PNG
(US10179804, Example 60 | US8846601, 60 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C51H72N18O9/c1-29(70)63-36(17-10-20-59-49(53)54)43(73)67-40-24-41(71)58-19-9-8-16-35(42(52)72)64-45(75)38(22-31-26-61-34-15-7-6-14-33(31)34)65-44(74)37(18-11-21-60-50(55)56)68-48(78)51(2,25-30-12-4-3-5-13-30)69-47(77)39(66-46(40)76)23-32-27-57-28-62-32/h3-7,12-15,26-28,35-40,61H,8-11,16-25H2,1-2H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,75)(H,65,74)(H,66,76)(H,67,73)(H,68,78)(H,69,77)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40-,51+/m0/s1
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47n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85495
PNG
(DPhe6-Bn(6-13)propylamide)
Show SMILES CCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H71N13O9/c1-7-19-54-46(68)38(20-28(2)3)61-49(71)40(23-33-25-53-27-57-33)59-42(65)26-56-50(72)43(29(4)5)63-44(66)30(6)58-48(70)39(22-32-24-55-36-16-12-11-15-34(32)36)62-47(69)37(17-18-41(52)64)60-45(67)35(51)21-31-13-9-8-10-14-31/h8-16,24-25,27-30,35,37-40,43,55H,7,17-23,26,51H2,1-6H3,(H2,52,64)(H,53,57)(H,54,68)(H,56,72)(H,58,70)(H,59,65)(H,60,67)(H,61,71)(H,62,69)(H,63,66)/t30-,35+,37-,38-,39-,40-,43-/m0/s1
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62n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85480
PNG
((3-Ph-Pr6)His7,DAla11,DPro13,Psi13-14,Phe14-Bn(6-1...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1CN[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C57H76N14O9/c1-33(2)49(56(79)66-34(3)51(74)69-47(28-39-30-61-32-64-39)57(80)71-25-13-18-40(71)31-63-45(50(60)73)26-37-16-9-6-10-17-37)70-52(75)35(4)65-55(78)46(27-38-29-62-43-20-12-11-19-41(38)43)68-54(77)44(23-24-48(59)72)67-53(76)42(58)22-21-36-14-7-5-8-15-36/h5-12,14-17,19-20,29-30,32-35,40,42,44-47,49,62-63H,13,18,21-28,31,58H2,1-4H3,(H2,59,72)(H2,60,73)(H,61,64)(H,65,78)(H,66,79)(H,67,76)(H,68,77)(H,69,74)(H,70,75)/t34-,35-,40-,42+,44-,45-,46-,47-,49-/m0/s1
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67n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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87 -10.0n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US10179804, Example 1 | US8846601, 1 | US8846601, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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87n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135668
PNG
(US10179804, Example 115 | US8846601, 53)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69N17O10/c1-28(68)61-35(16-9-19-57-49(52)53)43(71)67-40-24-41(69)56-18-8-7-15-34(42(51)70)62-46(74)38(22-30-25-59-33-14-6-5-13-32(30)33)65-44(72)36(17-10-20-58-50(54)77)63-45(73)37(21-29-11-3-2-4-12-29)64-47(75)39(66-48(40)76)23-31-26-55-27-60-31/h2-6,11-14,25-27,34-40,59H,7-10,15-24H2,1H3,(H2,51,70)(H,55,60)(H,56,69)(H,61,68)(H,62,74)(H,63,73)(H,64,75)(H,65,72)(H,66,76)(H,67,71)(H4,52,53,57)(H3,54,58,77)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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87n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135656
PNG
(US10179804, Example 41 | US8846601, 41 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39+,40-/m0/s1
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95n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135656
PNG
(US10179804, Example 41 | US8846601, 41 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39+,40-/m0/s1
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95 -9.96n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135656
PNG
(US10179804, Example 41 | US8846601, 41 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39+,40-/m0/s1
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95n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85482
PNG
(DPhe6-Bn(6-13)hexylamide)
Show SMILES CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C53H77N13O9/c1-7-8-9-15-22-57-49(71)41(23-31(2)3)64-52(74)43(26-36-28-56-30-60-36)62-45(68)29-59-53(75)46(32(4)5)66-47(69)33(6)61-51(73)42(25-35-27-58-39-19-14-13-18-37(35)39)65-50(72)40(20-21-44(55)67)63-48(70)38(54)24-34-16-11-10-12-17-34/h10-14,16-19,27-28,30-33,38,40-43,46,58H,7-9,15,20-26,29,54H2,1-6H3,(H2,55,67)(H,56,60)(H,57,71)(H,59,75)(H,61,73)(H,62,68)(H,63,70)(H,64,74)(H,65,72)(H,66,69)/t33-,38+,40-,41-,42-,43-,46-/m0/s1
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100n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135668
PNG
(US10179804, Example 115 | US8846601, 53)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69N17O10/c1-28(68)61-35(16-9-19-57-49(52)53)43(71)67-40-24-41(69)56-18-8-7-15-34(42(51)70)62-46(74)38(22-30-25-59-33-14-6-5-13-32(30)33)65-44(72)36(17-10-20-58-50(54)77)63-45(73)37(21-29-11-3-2-4-12-29)64-47(75)39(66-48(40)76)23-31-26-55-27-60-31/h2-6,11-14,25-27,34-40,59H,7-10,15-24H2,1H3,(H2,51,70)(H,55,60)(H,56,69)(H,61,68)(H,62,74)(H,63,73)(H,64,75)(H,65,72)(H,66,76)(H,67,71)(H4,52,53,57)(H3,54,58,77)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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214n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Gastrin-Releasing peptide


(RAT)
BDBM85479
PNG
(DPhe6-Bn(1-13)NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(C)C)C(N)=O
Show InChI InChI=1S/C71H104N22O16/c1-36(2)26-49(60(74)99)90-69(108)53(30-42-32-77-35-82-42)86-58(98)34-81-70(109)59(38(5)6)93-61(100)39(7)83-67(106)52(29-41-31-79-44-17-12-11-16-43(41)44)92-66(105)48(20-23-55(73)95)89-68(107)51(28-40-14-9-8-10-15-40)85-57(97)33-80-62(101)50(27-37(3)4)91-63(102)45(18-13-25-78-71(75)76)87-65(104)47(19-22-54(72)94)88-64(103)46-21-24-56(96)84-46/h8-12,14-17,31-32,35-39,45-53,59,79H,13,18-30,33-34H2,1-7H3,(H2,72,94)(H2,73,95)(H2,74,99)(H,77,82)(H,80,101)(H,81,109)(H,83,106)(H,84,96)(H,85,97)(H,86,98)(H,87,104)(H,88,103)(H,89,107)(H,90,108)(H,91,102)(H,92,105)(H,93,100)(H4,75,76,78)/t39-,45-,46-,47-,48-,49-,50-,51+,52-,53-,59-/m0/s1
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450n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135621
PNG
(US10179804, Example 6 | US8846601, 6 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(18-11-21-57-50(53)54)44(70)66-41-25-42(68)56-20-10-8-16-35(43(52)69)61-47(73)39(23-31-26-58-34-15-6-5-14-33(31)34)64-45(71)37(17-7-9-19-51)62-46(72)38(22-30-12-3-2-4-13-30)63-48(74)40(65-49(41)75)24-32-27-55-28-59-32/h2-6,12-15,26-28,35-41,58H,7-11,16-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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533n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135621
PNG
(US10179804, Example 6 | US8846601, 6 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(18-11-21-57-50(53)54)44(70)66-41-25-42(68)56-20-10-8-16-35(43(52)69)61-47(73)39(23-31-26-58-34-15-6-5-14-33(31)34)64-45(71)37(17-7-9-19-51)62-46(72)38(22-30-12-3-2-4-13-30)63-48(74)40(65-49(41)75)24-32-27-55-28-59-32/h2-6,12-15,26-28,35-41,58H,7-11,16-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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533 -8.90n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135621
PNG
(US10179804, Example 6 | US8846601, 6 | US9458201, ...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(18-11-21-57-50(53)54)44(70)66-41-25-42(68)56-20-10-8-16-35(43(52)69)61-47(73)39(23-31-26-58-34-15-6-5-14-33(31)34)64-45(71)37(17-7-9-19-51)62-46(72)38(22-30-12-3-2-4-13-30)63-48(74)40(65-49(41)75)24-32-27-55-28-59-32/h2-6,12-15,26-28,35-41,58H,7-11,16-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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533n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85494
PNG
(DPhe6-Bn(6-13)NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O
Show InChI InChI=1S/C47H65N13O9/c1-25(2)17-35(41(50)63)58-46(68)37(20-30-22-51-24-54-30)56-39(62)23-53-47(69)40(26(3)4)60-42(64)27(5)55-45(67)36(19-29-21-52-33-14-10-9-13-31(29)33)59-44(66)34(15-16-38(49)61)57-43(65)32(48)18-28-11-7-6-8-12-28/h6-14,21-22,24-27,32,34-37,40,52H,15-20,23,48H2,1-5H3,(H2,49,61)(H2,50,63)(H,51,54)(H,53,69)(H,55,67)(H,56,62)(H,57,65)(H,58,68)(H,59,66)(H,60,64)/t27-,32+,34-,35-,36-,37-,40-/m0/s1
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974n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
Bombesin 4


(Frog)
BDBM85490
PNG
(DPhe6,Leu13,Psi(CH2NH),Cpa14-Bn(6-14))
Show SMILES CC(C)C[C@@H](CN[C@@H](C#N)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H69N15O9/c1-27(2)17-33(24-57-40(21-51)44(54)68)61-49(73)39(20-32-23-55-26-59-32)62-42(67)25-58-50(74)43(28(3)4)65-45(69)29(5)60-48(72)38(19-31-22-56-36-14-10-9-13-34(31)36)64-47(71)37(15-16-41(53)66)63-46(70)35(52)18-30-11-7-6-8-12-30/h6-14,22-23,26-29,33,35,37-40,43,56-57H,15-20,24-25,52H2,1-5H3,(H2,53,66)(H2,54,68)(H,55,59)(H,58,74)(H,60,72)(H,61,73)(H,62,67)(H,63,70)(H,64,71)(H,65,69)/t29-,33-,35+,37-,38-,39-,40-,43-/m0/s1
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1.29E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
BRS3


(Homo sapiens (Human))
BDBM85495
PNG
(DPhe6-Bn(6-13)propylamide)
Show SMILES CCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H71N13O9/c1-7-19-54-46(68)38(20-28(2)3)61-49(71)40(23-33-25-53-27-57-33)59-42(65)26-56-50(72)43(29(4)5)63-44(66)30(6)58-48(70)39(22-32-24-55-36-16-12-11-15-34(32)36)62-47(69)37(17-18-41(52)64)60-45(67)35(51)21-31-13-9-8-10-14-31/h8-16,24-25,27-30,35,37-40,43,55H,7,17-23,26,51H2,1-6H3,(H2,52,64)(H,53,57)(H,54,68)(H,56,72)(H,58,70)(H,59,65)(H,60,67)(H,61,71)(H,62,69)(H,63,66)/t30-,35+,37-,38-,39-,40-,43-/m0/s1
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1.90E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
NMB


(RAT)
BDBM85490
PNG
(DPhe6,Leu13,Psi(CH2NH),Cpa14-Bn(6-14))
Show SMILES CC(C)C[C@@H](CN[C@@H](C#N)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H69N15O9/c1-27(2)17-33(24-57-40(21-51)44(54)68)61-49(73)39(20-32-23-55-26-59-32)62-42(67)25-58-50(74)43(28(3)4)65-45(69)29(5)60-48(72)38(19-31-22-56-36-14-10-9-13-34(31)36)64-47(71)37(15-16-41(53)66)63-46(70)35(52)18-30-11-7-6-8-12-30/h6-14,22-23,26-29,33,35,37-40,43,56-57H,15-20,24-25,52H2,1-5H3,(H2,53,66)(H2,54,68)(H,55,59)(H,58,74)(H,60,72)(H,61,73)(H,62,67)(H,63,70)(H,64,71)(H,65,69)/t29-,33-,35+,37-,38-,39-,40-,43-/m0/s1
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2.70E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
BRS3


(Homo sapiens (Human))
BDBM85482
PNG
(DPhe6-Bn(6-13)hexylamide)
Show SMILES CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C53H77N13O9/c1-7-8-9-15-22-57-49(71)41(23-31(2)3)64-52(74)43(26-36-28-56-30-60-36)62-45(68)29-59-53(75)46(32(4)5)66-47(69)33(6)61-51(73)42(25-35-27-58-39-19-14-13-18-37(35)39)65-50(72)40(20-21-44(55)67)63-48(70)38(54)24-34-16-11-10-12-17-34/h10-14,16-19,27-28,30-33,38,40-43,46,58H,7-9,15,20-26,29,54H2,1-6H3,(H2,55,67)(H,56,60)(H,57,71)(H,59,75)(H,61,73)(H,62,68)(H,63,70)(H,64,74)(H,65,72)(H,66,69)/t33-,38+,40-,41-,42-,43-,46-/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
NMB


(RAT)
BDBM85495
PNG
(DPhe6-Bn(6-13)propylamide)
Show SMILES CCCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C50H71N13O9/c1-7-19-54-46(68)38(20-28(2)3)61-49(71)40(23-33-25-53-27-57-33)59-42(65)26-56-50(72)43(29(4)5)63-44(66)30(6)58-48(70)39(22-32-24-55-36-16-12-11-15-34(32)36)62-47(69)37(17-18-41(52)64)60-45(67)35(51)21-31-13-9-8-10-14-31/h8-16,24-25,27-30,35,37-40,43,55H,7,17-23,26,51H2,1-6H3,(H2,52,64)(H,53,57)(H,54,68)(H,56,72)(H,58,70)(H,59,65)(H,60,67)(H,61,71)(H,62,69)(H,63,66)/t30-,35+,37-,38-,39-,40-,43-/m0/s1
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4.60E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database




Biochemistry 38: 7307-20 (1999)


Article DOI: 10.1021/bi990204w
BindingDB Entry DOI: 10.7270/Q29022BG
More data for this
Ligand-Target Pair
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