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3 similar compounds to monomer 17660

Wt: 189.1
BDBM86211
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Wt: 203.1
BDBM50069348
Wt: 189.1
BDBM50164445
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 86211,50069348,50164445   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
metabotropic glutamate 1/2


(RAT)
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
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PubMed
0.0300n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database




Mol Pharmacol 63: 1082-93 (2003)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database




Mol Pharmacol 63: 1082-93 (2003)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
PDB
MMDB

KEGG

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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 711-21 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 711-21 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 711-21 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM86211
PNG
(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Show SMILES NC(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
PDB
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KEGG

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Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche

Curated by PDSP Ki Database




J Pharmacol Exp Ther 315: 711-21 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50069348
PNG
((S)-2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES C[C@](N)(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c1-6(7,3(10)11)2-9-4(12)8-5(13)14-9/h2,7H2,1H3,(H,10,11)(H,8,12,13)/t6-/m0/s1
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PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 6 stably expressed in chinese hamster ovary (CHO) cells


Bioorg Med Chem Lett 8: 447-52 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50164445
PNG
(2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-pr...)
Show SMILES N[C@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
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CHEMBL
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Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50069348
PNG
((S)-2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Show SMILES C[C@](N)(Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H9N3O5/c1-6(7,3(10)11)2-9-4(12)8-5(13)14-9/h2,7H2,1H3,(H,10,11)(H,8,12,13)/t6-/m0/s1
UniProtKB/SwissProt

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PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 4a stably expressed in chinese hamster ovary (CHO) cells


Bioorg Med Chem Lett 8: 447-52 (1999)

More data for this
Ligand-Target Pair