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7 similar compounds to monomer 85017

Wt: 153.1
BDBM86315
Wt: 153.1
BDBM86316
Wt: 153.1
BDBM86317
Wt: 185.1
BDBM50052255
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Wt: 185.1
BDBM50052256
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Wt: 185.1
BDBM50084139
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Wt: 187.1
BDBM50089911
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 86315,86316,86317,50052255,50052256,50084139,50089911   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory Amino Acid EAAT2


()
BDBM86316
PNG
(WAY-855)
Show SMILES N[C@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8+/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM86316
PNG
(WAY-855)
Show SMILES N[C@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8+/m0/s1
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2.57E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM86317
PNG
(WAY-865)
Show SMILES N[C@]1([C@H]2C3C[C@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4-,5?,6-,8-/m1/s1
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2.57E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86316
PNG
(WAY-855)
Show SMILES N[C@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM86315
PNG
(WAY-879)
Show SMILES N[C@@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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2.50E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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1.03E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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1.22E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 partial


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Antagonist potency against cloned Metabotropic glutamate receptor 2


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a 1.03E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a at half maximal concentration


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a 1.03E+5n/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Concentration required to inhibit mGluR5a receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084139
PNG
(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Show SMILES NC(C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)
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n/an/an/an/a 1.03E+5n/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells


J Med Chem 48: 2534-47 (2005)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Lilly Research Labs

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu1 receptor


J Med Chem 50: 2563-8 (2007)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mGluR1a receptor


J Med Chem 54: 2529-91 (2011)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50084139
PNG
(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Show SMILES NC(C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Inhibitory activity against mGluR1 receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)

More data for this
Ligand-Target Pair