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5 similar compounds to monomer 24656

Compile data set for download or QSAR
Wt: 194.2
BDBM8931
Wt: 178.6
BDBM19475
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Wt: 220.2
BDBM49002
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Wt: 159.1
BDBM50342657
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Wt: 173.2
BDBM50342658
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8931,19475,49002,50342657,50342658   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B1, mitochondrial


(Homo sapiens (Human))
BDBM8931
PNG
(5-(2-Naphthyl)-1H-imidazole | 5-(naphthalen-2-yl)-...)
Show SMILES c1nc(c[nH]1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C13H10N2/c1-2-4-11-7-12(6-5-10(11)3-1)13-8-14-9-15-13/h1-9H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
n/an/a 207n/an/an/an/an/an/a



Saarland University



Assay Description
The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...


J Med Chem 48: 6632-42 (2005)


Article DOI: 10.1021/jm0503704
BindingDB Entry DOI: 10.7270/Q2H41PNT
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM8931
PNG
(5-(2-Naphthyl)-1H-imidazole | 5-(naphthalen-2-yl)-...)
Show SMILES c1nc(c[nH]1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C13H10N2/c1-2-4-11-7-12(6-5-10(11)3-1)13-8-14-9-15-13/h1-9H,(H,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 296n/an/an/an/an/an/a



Saarland University



Assay Description
The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...


J Med Chem 48: 6632-42 (2005)


Article DOI: 10.1021/jm0503704
BindingDB Entry DOI: 10.7270/Q2H41PNT
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM49002
PNG
(4,5-diphenyl-1H-imidazole | MLS000080782 | SMR0000...)
Show SMILES c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2/c1-3-7-12(8-4-1)14-15(17-11-16-14)13-9-5-2-6-10-13/h1-11H,(H,16,17)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


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PCBioAssay
n/an/an/an/a 0.00370n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Val Watts Assay Provider Affiliation: Purdue University Grant Title: Allosteric Modulators of D1 Receptors Grant Number: 1 X01 MH0776...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2H41PVH
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens (Human))
BDBM50342658
PNG
((4-(1H-imidazol-4-yl)phenyl)methanamine | CHEMBL17...)
Show SMILES NCc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C10H11N3/c11-5-8-1-3-9(4-2-8)10-6-12-7-13-10/h1-4,6-7H,5,11H2,(H,12,13)
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.115
BindingDB Entry DOI: 10.7270/Q2QV3MVJ
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM49002
PNG
(4,5-diphenyl-1H-imidazole | MLS000080782 | SMR0000...)
Show SMILES c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2/c1-3-7-12(8-4-1)14-15(17-11-16-14)13-9-5-2-6-10-13/h1-11H,(H,16,17)
PDB
MMDB

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US Patent
n/an/a 1.00E+5n/an/an/an/a7.4n/a



The Procter & Gamble Company

US Patent


Assay Description
All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...


US Patent US9144538 (2015)


BindingDB Entry DOI: 10.7270/Q22806DV
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens (Human))
BDBM50342657
PNG
(4-(1H-imidazol-4-yl)aniline | CHEMBL1770736)
Show SMILES Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C9H9N3/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H,10H2,(H,11,12)
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4.30E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.115
BindingDB Entry DOI: 10.7270/Q2QV3MVJ
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM49002
PNG
(4,5-diphenyl-1H-imidazole | MLS000080782 | SMR0000...)
Show SMILES c1nc(c([nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2/c1-3-7-12(8-4-1)14-15(17-11-16-14)13-9-5-2-6-10-13/h1-11H,(H,16,17)
PDB
MMDB

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PC cid
PC sid
UniChem

Patents


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US Patent
n/an/a 1.00E+5n/an/an/an/a7.44



The Procter & Gamble Company

US Patent


Assay Description
Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...


US Patent US9138393 (2015)


BindingDB Entry DOI: 10.7270/Q2GF0S8J
More data for this
Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 8931,19475,49002,50342657,50342658
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
Cytochrome P450 2B4

(Oryctolagus cuniculus)
BDBM19475
JPEG
(4-(4-chlorophenyl)imidazole | 4-CPI | 5-(4-chlorop...)
GoogleScholar
PDB
MMDB
PC cid
PC sid
PDB
n/a-1.74-6.476.057.4025



Anhui Medical University





Zhonghua Wai Ke Za Zhi 41: 186-8 (2003)

Cytochrome P450 2B4 Mutant (F206A)

(Oryctolagus cuniculus (rabbit))
BDBM19475
JPEG
(4-(4-chlorophenyl)imidazole | 4-CPI | 5-(4-chlorop...)
GoogleScholar
PDB
MMDB
PC cid
PC sid
PDB
n/an/a-10.96.337.4025



Anhui Medical University





Zhonghua Wai Ke Za Zhi 41: 186-8 (2003)