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3 similar compounds to monomer 14322

Compile data set for download or QSAR
Wt: 159.1
BDBM92299
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Wt: 158.1
BDBM50084506
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Wt: 144.1
BDBM50091818
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 92299,50084506,50091818   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50091818
PNG
(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Show SMILES Nc1cc2ccccc2cn1
Show InChI InChI=1S/C9H8N2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H2,10,11)
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PubMed
>3.00E+4>-6.17n/an/an/an/an/a7.425



CSAR



Assay Description
Abbott uPA__Urokinase Human - Ki(uM)


CSAR 1: (2012)

More data for this
Ligand-Target Pair
Urokinase


(Homo sapiens (Human))
BDBM50091818
PNG
(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Show SMILES Nc1cc2ccccc2cn1
Show InChI InChI=1S/C9H8N2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H2,10,11)
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D3R
>3.00E+4n/an/an/an/an/an/an/an/a



D3R



Assay Description
Photometric_Method1


D3R 227: (2015)


BindingDB Entry DOI: 10.7270/Q24B305P
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92299
PNG
(uPa_23)
Show SMILES Nc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C9H9N3/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,10H2,(H2,11,12)
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1.00E+5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of urokinase


J Med Chem 52: 3159-65 (2009)


Article DOI: 10.1021/jm801444x
BindingDB Entry DOI: 10.7270/Q2FF3TM8
More data for this
Ligand-Target Pair
Urokinase


(Homo sapiens (Human))
BDBM92299
PNG
(uPa_23)
Show SMILES Nc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C9H9N3/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,10H2,(H2,11,12)
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D3R
>1.04E+5n/an/an/an/an/an/an/an/a



D3R



Assay Description
Photometric_Method1


D3R 227: (2015)


BindingDB Entry DOI: 10.7270/Q24B305P
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92299
PNG
(uPa_23)
Show SMILES Nc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C9H9N3/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,10H2,(H2,11,12)
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>1.04E+5>-5.43n/an/an/an/an/a7.425



CSAR



Assay Description
Abbott uPA__Urokinase Human - Ki(uM)


CSAR 1: (2012)

More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50091818
PNG
(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Show SMILES Nc1cc2ccccc2cn1
Show InChI InChI=1S/C9H8N2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H2,10,11)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories Rahway

Curated by ChEMBL


Assay Description
Inhibitory activity against inducible nitric oxide synthase (iNOS)


Bioorg Med Chem Lett 10: 1975-8 (2001)


Article DOI: 10.1016/s0960-894x(00)00389-9
BindingDB Entry DOI: 10.7270/Q2319V30
More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50084506
PNG
(CHEMBL319543 | Methyl-quinolin-2-yl-amine)
Show SMILES CNc1ccc2ccccc2n1
Show InChI InChI=1S/C10H10N2/c1-11-10-7-6-8-4-2-3-5-9(8)12-10/h2-7H,1H3,(H,11,12)
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n/an/an/a 3.80E+5n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)


Article DOI: 10.1021/jm049533z
BindingDB Entry DOI: 10.7270/Q26M369B
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50091818
PNG
(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Show SMILES Nc1cc2ccccc2cn1
Show InChI InChI=1S/C9H8N2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H2,10,11)
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n/an/a 3.76E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...


ACS Med Chem Lett 1: 439-442 (2010)


Article DOI: 10.1021/ml100136n
BindingDB Entry DOI: 10.7270/Q22807WJ
More data for this
Ligand-Target Pair