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39 similar compounds to monomer 50352724

Compile data set for download or QSAR
Wt: 560.5
BDBM50352699
Wt: 516.4
BDBM50352706
Wt: 528.0
BDBM50352707
Wt: 496.0
BDBM50352708
Wt: 550.9
BDBM50352709
Wt: 534.9
BDBM50352725
Wt: 554.4
BDBM50352726
Wt: 445.5
BDBM50352729
Wt: 494.0
BDBM50352730
Wt: 486.4
BDBM50352739
Wt: 500.4
BDBM50352740
Wt: 500.4
BDBM50352741
Wt: 514.4
BDBM50352742
Wt: 548.5
BDBM50352743
Wt: 452.4
BDBM50352744
Displayed 1 to 15 (of 39 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50352699,50352706,50352707,50352708,50352709,50352725,50352726,50352729,50352730,50352739,50352740,50352741,50352742,50352743,50352744   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352742
PNG
(CHEMBL1822898 | US8835436, Example 7)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H33Cl2N5O/c1-3-9-24-31-26(20(2)34(24)21-10-5-4-6-11-21)27(35)30-14-8-15-32-16-18-33(19-17-32)23-13-7-12-22(28)25(23)29/h4-7,10-13H,3,8-9,14-19H2,1-2H3,(H,30,35)
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n/an/a 21n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352743
PNG
(CHEMBL1822899)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C30H31Cl2N5O/c1-22-28(34-29(23-10-4-2-5-11-23)37(22)24-12-6-3-7-13-24)30(38)33-16-9-17-35-18-20-36(21-19-35)26-15-8-14-25(31)27(26)32/h2-8,10-15H,9,16-21H2,1H3,(H,33,38)
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n/an/a 109n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352741
PNG
(CHEMBL1822897 | US8835436, Example 12)
Show SMILES CCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-8-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 48n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352739
PNG
(CHEMBL1822894 | US8835436, Example 13)
Show SMILES CCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-3-22-29-24(18(2)32(22)19-8-5-4-6-9-19)25(33)28-12-13-30-14-16-31(17-15-30)21-11-7-10-20(26)23(21)27/h4-11H,3,12-17H2,1-2H3,(H,28,33)
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n/an/a 27n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 63.1n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352742
PNG
(CHEMBL1822898 | US8835436, Example 7)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H33Cl2N5O/c1-3-9-24-31-26(20(2)34(24)21-10-5-4-6-11-21)27(35)30-14-8-15-32-16-18-33(19-17-32)23-13-7-12-22(28)25(23)29/h4-7,10-13H,3,8-9,14-19H2,1-2H3,(H,30,35)
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n/an/a 189n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352740
PNG
(CHEMBL1822895 | US8835436, Example 9)
Show SMILES CCCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-8-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 109n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352741
PNG
(CHEMBL1822897 | US8835436, Example 12)
Show SMILES CCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-8-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 140n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352739
PNG
(CHEMBL1822894 | US8835436, Example 13)
Show SMILES CCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-3-22-29-24(18(2)32(22)19-8-5-4-6-9-19)25(33)28-12-13-30-14-16-31(17-15-30)21-11-7-10-20(26)23(21)27/h4-11H,3,12-17H2,1-2H3,(H,28,33)
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n/an/a 62n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 544n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352742
PNG
(CHEMBL1822898 | US8835436, Example 7)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H33Cl2N5O/c1-3-9-24-31-26(20(2)34(24)21-10-5-4-6-11-21)27(35)30-14-8-15-32-16-18-33(19-17-32)23-13-7-12-22(28)25(23)29/h4-7,10-13H,3,8-9,14-19H2,1-2H3,(H,30,35)
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n/an/a 13n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352740
PNG
(CHEMBL1822895 | US8835436, Example 9)
Show SMILES CCCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-8-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 82n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 51.8n/an/an/an/a7.4n/a



Green Cross Corporation

US Patent


Assay Description
For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...


US Patent US8835436 (2014)


BindingDB Entry DOI: 10.7270/Q24T6H2H
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 63.1n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 544n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352699
PNG
(CHEMBL1823187 | US8835436, Example 136)
Show SMILES CCCc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccc(OC)cc1
Show InChI InChI=1S/C28H35Cl2N5O3/c1-4-6-25-32-27(19(2)35(25)20-9-11-22(38-3)12-10-20)28(37)31-17-21(36)18-33-13-15-34(16-14-33)24-8-5-7-23(29)26(24)30/h5,7-12,21,36H,4,6,13-18H2,1-3H3,(H,31,37)
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n/an/a 51.8n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352706
PNG
(CHEMBL1823204)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C26H31Cl2N5O2/c1-17-23(28)8-5-9-24(17)32-12-10-31(11-13-32)16-22(34)15-29-26(35)25-18(2)33(19(3)30-25)21-7-4-6-20(27)14-21/h4-9,14,22,34H,10-13,15-16H2,1-3H3,(H,29,35)
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n/an/a 182n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50352707
PNG
(CHEMBL1823065)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C31H34ClN5O/c1-23-27(32)15-9-16-28(23)36-21-19-35(20-22-36)18-10-17-33-31(38)29-24(2)37(26-13-7-4-8-14-26)30(34-29)25-11-5-3-6-12-25/h3-9,11-16H,10,17-22H2,1-2H3,(H,33,38)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50352707
PNG
(CHEMBL1823065)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C31H34ClN5O/c1-23-27(32)15-9-16-28(23)36-21-19-35(20-22-36)18-10-17-33-31(38)29-24(2)37(26-13-7-4-8-14-26)30(34-29)25-11-5-3-6-12-25/h3-9,11-16H,10,17-22H2,1-2H3,(H,33,38)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP1A2 by luceferin-based assay


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50352707
PNG
(CHEMBL1823065)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C31H34ClN5O/c1-23-27(32)15-9-16-28(23)36-21-19-35(20-22-36)18-10-17-33-31(38)29-24(2)37(26-13-7-4-8-14-26)30(34-29)25-11-5-3-6-12-25/h3-9,11-16H,10,17-22H2,1-2H3,(H,33,38)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 by luceferin-based assay


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50352707
PNG
(CHEMBL1823065)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C31H34ClN5O/c1-23-27(32)15-9-16-28(23)36-21-19-35(20-22-36)18-10-17-33-31(38)29-24(2)37(26-13-7-4-8-14-26)30(34-29)25-11-5-3-6-12-25/h3-9,11-16H,10,17-22H2,1-2H3,(H,33,38)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2D6 by luceferin-based assay


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50352707
PNG
(CHEMBL1823065)
Show SMILES Cc1c(nc(-c2ccccc2)n1-c1ccccc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C31H34ClN5O/c1-23-27(32)15-9-16-28(23)36-21-19-35(20-22-36)18-10-17-33-31(38)29-24(2)37(26-13-7-4-8-14-26)30(34-29)25-11-5-3-6-12-25/h3-9,11-16H,10,17-22H2,1-2H3,(H,33,38)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 by luceferin-based assay


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352706
PNG
(CHEMBL1823204)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C26H31Cl2N5O2/c1-17-23(28)8-5-9-24(17)32-12-10-31(11-13-32)16-22(34)15-29-26(35)25-18(2)33(19(3)30-25)21-7-4-6-20(27)14-21/h4-9,14,22,34H,10-13,15-16H2,1-3H3,(H,29,35)
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n/an/a 557n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352706
PNG
(CHEMBL1823204)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C26H31Cl2N5O2/c1-17-23(28)8-5-9-24(17)32-12-10-31(11-13-32)16-22(34)15-29-26(35)25-18(2)33(19(3)30-25)21-7-4-6-20(27)14-21/h4-9,14,22,34H,10-13,15-16H2,1-3H3,(H,29,35)
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n/an/a 14.2n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352708
PNG
(CHEMBL1823205)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C27H34ClN5O2/c1-18-7-5-10-25(19(18)2)32-13-11-31(12-14-32)17-24(34)16-29-27(35)26-20(3)33(21(4)30-26)23-9-6-8-22(28)15-23/h5-10,15,24,34H,11-14,16-17H2,1-4H3,(H,29,35)
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n/an/a 275n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352708
PNG
(CHEMBL1823205)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C27H34ClN5O2/c1-18-7-5-10-25(19(18)2)32-13-11-31(12-14-32)17-24(34)16-29-27(35)26-20(3)33(21(4)30-26)23-9-6-8-22(28)15-23/h5-10,15,24,34H,11-14,16-17H2,1-4H3,(H,29,35)
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n/an/a 535n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352708
PNG
(CHEMBL1823205)
Show SMILES Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C27H34ClN5O2/c1-18-7-5-10-25(19(18)2)32-13-11-31(12-14-32)17-24(34)16-29-27(35)26-20(3)33(21(4)30-26)23-9-6-8-22(28)15-23/h5-10,15,24,34H,11-14,16-17H2,1-4H3,(H,29,35)
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n/an/a 2.90n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352709
PNG
(CHEMBL1823206)
Show SMILES CCCc1nc(cn1-c1ccc(Cl)cc1)C(=O)NCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H30Cl3N5O2/c1-2-4-24-31-22(17-34(24)19-9-7-18(27)8-10-19)26(36)30-15-20(35)16-32-11-13-33(14-12-32)23-6-3-5-21(28)25(23)29/h3,5-10,17,20,35H,2,4,11-16H2,1H3,(H,30,36)
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n/an/a 177n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352709
PNG
(CHEMBL1823206)
Show SMILES CCCc1nc(cn1-c1ccc(Cl)cc1)C(=O)NCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H30Cl3N5O2/c1-2-4-24-31-22(17-34(24)19-9-7-18(27)8-10-19)26(36)30-15-20(35)16-32-11-13-33(14-12-32)23-6-3-5-21(28)25(23)29/h3,5-10,17,20,35H,2,4,11-16H2,1H3,(H,30,36)
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n/an/a 856n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352709
PNG
(CHEMBL1823206)
Show SMILES CCCc1nc(cn1-c1ccc(Cl)cc1)C(=O)NCC(O)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H30Cl3N5O2/c1-2-4-24-31-22(17-34(24)19-9-7-18(27)8-10-19)26(36)30-15-20(35)16-32-11-13-33(14-12-32)23-6-3-5-21(28)25(23)29/h3,5-10,17,20,35H,2,4,11-16H2,1H3,(H,30,36)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352725
PNG
(CHEMBL1822911)
Show SMILES CCCc1nc(cn1-c1ccc(Cl)cc1)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H30Cl3N5O/c1-2-5-24-31-22(18-34(24)20-10-8-19(27)9-11-20)26(35)30-12-4-13-32-14-16-33(17-15-32)23-7-3-6-21(28)25(23)29/h3,6-11,18H,2,4-5,12-17H2,1H3,(H,30,35)
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n/an/a 715n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352726
PNG
(CHEMBL1822912)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28Cl2F3N5O/c1-17-24(33-18(2)36(17)21-9-4-3-7-19(21)26(29,30)31)25(37)32-11-6-12-34-13-15-35(16-14-34)22-10-5-8-20(27)23(22)28/h3-5,7-10H,6,11-16H2,1-2H3,(H,32,37)
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n/an/a 58n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352726
PNG
(CHEMBL1822912)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28Cl2F3N5O/c1-17-24(33-18(2)36(17)21-9-4-3-7-19(21)26(29,30)31)25(37)32-11-6-12-34-13-15-35(16-14-34)22-10-5-8-20(27)23(22)28/h3-5,7-10H,6,11-16H2,1-2H3,(H,32,37)
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n/an/a 155n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352726
PNG
(CHEMBL1822912)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28Cl2F3N5O/c1-17-24(33-18(2)36(17)21-9-4-3-7-19(21)26(29,30)31)25(37)32-11-6-12-34-13-15-35(16-14-34)22-10-5-8-20(27)23(22)28/h3-5,7-10H,6,11-16H2,1-2H3,(H,32,37)
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n/an/a 42n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352729
PNG
(CHEMBL1823056)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H35N5O/c1-20-10-8-13-25(21(20)2)31-18-16-30(17-19-31)15-9-14-28-27(33)26-22(3)32(23(4)29-26)24-11-6-5-7-12-24/h5-8,10-13H,9,14-19H2,1-4H3,(H,28,33)
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n/an/a 91n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352729
PNG
(CHEMBL1823056)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H35N5O/c1-20-10-8-13-25(21(20)2)31-18-16-30(17-19-31)15-9-14-28-27(33)26-22(3)32(23(4)29-26)24-11-6-5-7-12-24/h5-8,10-13H,9,14-19H2,1-4H3,(H,28,33)
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n/an/a 170n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352729
PNG
(CHEMBL1823056)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H35N5O/c1-20-10-8-13-25(21(20)2)31-18-16-30(17-19-31)15-9-14-28-27(33)26-22(3)32(23(4)29-26)24-11-6-5-7-12-24/h5-8,10-13H,9,14-19H2,1-4H3,(H,28,33)
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n/an/a 6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352730
PNG
(CHEMBL1823057)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C28H36ClN5O/c1-4-10-26-31-27(22(3)34(26)23-11-6-5-7-12-23)28(35)30-15-9-16-32-17-19-33(20-18-32)25-14-8-13-24(29)21(25)2/h5-8,11-14H,4,9-10,15-20H2,1-3H3,(H,30,35)
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n/an/a 154n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352730
PNG
(CHEMBL1823057)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C28H36ClN5O/c1-4-10-26-31-27(22(3)34(26)23-11-6-5-7-12-23)28(35)30-15-9-16-32-17-19-33(20-18-32)25-14-8-13-24(29)21(25)2/h5-8,11-14H,4,9-10,15-20H2,1-3H3,(H,30,35)
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n/an/a 604n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352730
PNG
(CHEMBL1823057)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2C)c(C)n1-c1ccccc1
Show InChI InChI=1S/C28H36ClN5O/c1-4-10-26-31-27(22(3)34(26)23-11-6-5-7-12-23)28(35)30-15-9-16-32-17-19-33(20-18-32)25-14-8-13-24(29)21(25)2/h5-8,11-14H,4,9-10,15-20H2,1-3H3,(H,30,35)
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n/an/a 3.90n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352739
PNG
(CHEMBL1822894 | US8835436, Example 13)
Show SMILES CCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-3-22-29-24(18(2)32(22)19-8-5-4-6-9-19)25(33)28-12-13-30-14-16-31(17-15-30)21-11-7-10-20(26)23(21)27/h4-11H,3,12-17H2,1-2H3,(H,28,33)
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n/an/a 27n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352739
PNG
(CHEMBL1822894 | US8835436, Example 13)
Show SMILES CCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-3-22-29-24(18(2)32(22)19-8-5-4-6-9-19)25(33)28-12-13-30-14-16-31(17-15-30)21-11-7-10-20(26)23(21)27/h4-11H,3,12-17H2,1-2H3,(H,28,33)
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n/an/a 62n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352739
PNG
(CHEMBL1822894 | US8835436, Example 13)
Show SMILES CCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-3-22-29-24(18(2)32(22)19-8-5-4-6-9-19)25(33)28-12-13-30-14-16-31(17-15-30)21-11-7-10-20(26)23(21)27/h4-11H,3,12-17H2,1-2H3,(H,28,33)
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n/an/a 245n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352740
PNG
(CHEMBL1822895 | US8835436, Example 9)
Show SMILES CCCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-8-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 39n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352740
PNG
(CHEMBL1822895 | US8835436, Example 9)
Show SMILES CCCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-8-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 109n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352740
PNG
(CHEMBL1822895 | US8835436, Example 9)
Show SMILES CCCc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-8-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 82n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352741
PNG
(CHEMBL1822897 | US8835436, Example 12)
Show SMILES CCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-8-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 48n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50352741
PNG
(CHEMBL1822897 | US8835436, Example 12)
Show SMILES CCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-8-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 140n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50352741
PNG
(CHEMBL1822897 | US8835436, Example 12)
Show SMILES CCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C26H31Cl2N5O/c1-3-23-30-25(19(2)33(23)20-9-5-4-6-10-20)26(34)29-13-8-14-31-15-17-32(18-16-31)22-12-7-11-21(27)24(22)28/h4-7,9-12H,3,8,13-18H2,1-2H3,(H,29,34)
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n/an/a 28n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50352742
PNG
(CHEMBL1822898 | US8835436, Example 7)
Show SMILES CCCc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C27H33Cl2N5O/c1-3-9-24-31-26(20(2)34(24)21-10-5-4-6-11-21)27(35)30-14-8-15-32-16-18-33(19-17-32)23-13-7-12-22(28)25(23)29/h4-7,10-13H,3,8-9,14-19H2,1-2H3,(H,30,35)
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n/an/a 21n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cells


J Med Chem 54: 6305-18 (2011)


Article DOI: 10.1021/jm200682b
BindingDB Entry DOI: 10.7270/Q2SX6DMC
More data for this
Ligand-Target Pair
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