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22 similar compounds to monomer 50256858

Compile data set for download or QSAR
Wt: 309.4
BDBM97457
Wt: 295.3
BDBM50128585
Wt: 309.4
BDBM50154012
Wt: 311.3
BDBM50154015
Wt: 325.4
BDBM50154016
Wt: 339.4
BDBM50154019
Wt: 371.4
BDBM50154020
Wt: 320.3
BDBM50154021
Wt: 387.4
BDBM50154022
Wt: 436.5
BDBM50154023
Wt: 385.4
BDBM50154024
Wt: 324.4
BDBM50154025
Wt: 309.4
BDBM50154029
Wt: 337.4
BDBM50154033
Wt: 281.3
BDBM50256913
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 97457,50128585,50154012,50154015,50154016,50154019,50154020,50154021,50154022,50154023,50154024,50154025,50154029,50154033,50256913   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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PubMed
n/an/a 63n/an/an/an/an/an/a



UniversitÓ degli Studi di Parma



Assay Description
Membrane fractions were prepared from Wistar rat brain homogenates, and FAAH activity were assayed by using [3H]anandamide (anandamide[ethanolamine-3...


ChemMedChem 1: 130-9 (2006)


Article DOI: 10.1002/cmdc.200500017
BindingDB Entry DOI: 10.7270/Q2XG9PRC
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Universit£ di Bologna

Curated by ChEMBL


Assay Description
Displacement of [3H]anandamide from FAAH in rat brain membranes after 30 mins by liquid scintillation counting


J Med Chem 60: 2287-2304 (2017)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Università degli Studi di Urbino Carlo Bo

Curated by ChEMBL


Assay Description
Fatty acid amide hydrolase inhibitory activity in rat brain membrane using [3H]-anandamide as a substrate


J Med Chem 46: 2352-60 (2003)


Article DOI: 10.1021/jm021119g
BindingDB Entry DOI: 10.7270/Q2DB817C
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154012
PNG
(CHEMBL184293 | Cyclohexyl-carbamic acid 3''-methyl...)
Show SMILES Cc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H23NO2/c1-15-7-5-8-16(13-15)17-9-6-12-19(14-17)23-20(22)21-18-10-3-2-4-11-18/h5-9,12-14,18H,2-4,10-11H2,1H3,(H,21,22)
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n/an/a 61.8n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154016
PNG
(CHEMBL360405 | Cyclohexyl-carbamic acid 3''-hydrox...)
Show SMILES OCc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H23NO3/c22-14-15-6-4-7-16(12-15)17-8-5-11-19(13-17)24-20(23)21-18-9-2-1-3-10-18/h4-8,11-13,18,22H,1-3,9-10,14H2,(H,21,23)
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n/an/a 8.67n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154015
PNG
(CHEMBL188301 | Cyclohexyl-carbamic acid 3''-hydrox...)
Show SMILES Oc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C19H21NO3/c21-17-10-4-6-14(12-17)15-7-5-11-18(13-15)23-19(22)20-16-8-2-1-3-9-16/h4-7,10-13,16,21H,1-3,8-9H2,(H,20,22)
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n/an/a 8.65n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154020
PNG
(CHEMBL185913 | Cyclohexyl-carbamic acid [1,1'';3''...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C25H25NO2/c27-25(26-23-14-5-2-6-15-23)28-24-16-8-13-22(18-24)21-12-7-11-20(17-21)19-9-3-1-4-10-19/h1,3-4,7-13,16-18,23H,2,5-6,14-15H2,(H,26,27)
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n/an/a 565n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154019
PNG
(CHEMBL189598 | Cyclohexyl-carbamic acid 3''-(2-hyd...)
Show SMILES OCCc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C21H25NO3/c23-13-12-16-6-4-7-17(14-16)18-8-5-11-20(15-18)25-21(24)22-19-9-2-1-3-10-19/h4-8,11,14-15,19,23H,1-3,9-10,12-13H2,(H,22,24)
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n/an/a 18.7n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154023
PNG
(CHEMBL360381 | Cyclohexylcarbamic acid derivative)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C26H32N2O4/c29-25(27-21-11-3-1-4-12-21)31-23-15-7-9-19(17-23)20-10-8-16-24(18-20)32-26(30)28-22-13-5-2-6-14-22/h7-10,15-18,21-22H,1-6,11-14H2,(H,27,29)(H,28,30)
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n/an/a 361n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154021
PNG
(CHEMBL186304 | Cyclohexyl-carbamic acid 3''-cyano-...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H20N2O2/c21-14-15-6-4-7-16(12-15)17-8-5-11-19(13-17)24-20(23)22-18-9-2-1-3-10-18/h4-8,11-13,18H,1-3,9-10H2,(H,22,23)
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n/an/a 33.9n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154022
PNG
(CHEMBL187001 | Cyclohexyl-carbamic acid 3''-phenox...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H25NO3/c27-25(26-21-11-3-1-4-12-21)29-24-16-8-10-20(18-24)19-9-7-15-23(17-19)28-22-13-5-2-6-14-22/h2,5-10,13-18,21H,1,3-4,11-12H2,(H,26,27)
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n/an/a 420n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154024
PNG
(CHEMBL184273 | Cyclohexyl-carbamic acid 3''-benzyl...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C26H27NO2/c28-26(27-24-14-5-2-6-15-24)29-25-16-8-13-23(19-25)22-12-7-11-21(18-22)17-20-9-3-1-4-10-20/h1,3-4,7-13,16,18-19,24H,2,5-6,14-15,17H2,(H,27,28)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154025
PNG
(CHEMBL189599 | Cyclohexyl-carbamic acid 3''-aminom...)
Show SMILES NCc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H24N2O2/c21-14-15-6-4-7-16(12-15)17-8-5-11-19(13-17)24-20(23)22-18-9-2-1-3-10-18/h4-8,11-13,18H,1-3,9-10,14,21H2,(H,22,23)
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n/an/a 2.12E+4n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154029
PNG
(CHEMBL184611 | Cyclohexyl-carbamic acid 4''-methyl...)
Show SMILES Cc1ccc(cc1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H23NO2/c1-15-10-12-16(13-11-15)17-6-5-9-19(14-17)23-20(22)21-18-7-3-2-4-8-18/h5-6,9-14,18H,2-4,7-8H2,1H3,(H,21,22)
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n/an/a 155n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50154033
PNG
(CHEMBL186781 | Cyclohexyl-carbamic acid 3''-propyl...)
Show SMILES CCCc1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C22H27NO2/c1-2-8-17-9-6-10-18(15-17)19-11-7-14-21(16-19)25-22(24)23-20-12-4-3-5-13-20/h6-7,9-11,14-16,20H,2-5,8,12-13H2,1H3,(H,23,24)
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n/an/a 110n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes


J Med Chem 47: 4998-5008 (2004)


Article DOI: 10.1021/jm031140x
BindingDB Entry DOI: 10.7270/Q2MS3S7X
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis


J Med Chem 51: 3487-98 (2008)


Article DOI: 10.1021/jm701631z
BindingDB Entry DOI: 10.7270/Q2TM79W9
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50256913
PNG
(CHEMBL448753 | Cyclopentyl-carbamic acid biphenyl-...)
Show SMILES O=C(NC1CCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H19NO2/c20-18(19-16-10-4-5-11-16)21-17-12-6-9-15(13-17)14-7-2-1-3-8-14/h1-3,6-9,12-13,16H,4-5,10-11H2,(H,19,20)
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n/an/a 34n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis


J Med Chem 51: 3487-98 (2008)


Article DOI: 10.1021/jm701631z
BindingDB Entry DOI: 10.7270/Q2TM79W9
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FAAH


Bioorg Med Chem Lett 21: 4674-85 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.096
BindingDB Entry DOI: 10.7270/Q2W959JK
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50256913
PNG
(CHEMBL448753 | Cyclopentyl-carbamic acid biphenyl-...)
Show SMILES O=C(NC1CCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H19NO2/c20-18(19-16-10-4-5-11-16)21-17-12-6-9-15(13-17)14-7-2-1-3-8-14/h1-3,6-9,12-13,16H,4-5,10-11H2,(H,19,20)
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n/an/a 33.9n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting


Eur J Med Chem 46: 4466-73 (2011)


Article DOI: 10.1016/j.ejmech.2011.07.021
BindingDB Entry DOI: 10.7270/Q2FB546B
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63.1n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting


Eur J Med Chem 46: 4466-73 (2011)


Article DOI: 10.1016/j.ejmech.2011.07.021
BindingDB Entry DOI: 10.7270/Q2FB546B
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Università degli Studi di Urbino Carlo Bo

Curated by ChEMBL


Assay Description
Inhibition of [3H]anandamide binding to fatty acid amide hydrolase of rat brain membrane


J Med Chem 46: 2352-60 (2003)


Article DOI: 10.1021/jm021119g
BindingDB Entry DOI: 10.7270/Q2DB817C
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50128585
PNG
(CHEMBL431202 | Cyclohexyl-carbamic acid biphenyl-3...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H21NO2/c21-19(20-17-11-5-2-6-12-17)22-18-13-7-10-16(14-18)15-8-3-1-4-9-15/h1,3-4,7-10,13-14,17H,2,5-6,11-12H2,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH


J Med Chem 51: 7327-43 (2009)


Article DOI: 10.1021/jm800311k
BindingDB Entry DOI: 10.7270/Q2J67HT8
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM97457
PNG
(FAAH Inhibitor, 2f)
Show SMILES Cc1ccc(OC(=O)NC2CCCCC2)cc1-c1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-15-12-13-18(14-19(15)16-8-4-2-5-9-16)23-20(22)21-17-10-6-3-7-11-17/h2,4-5,8-9,12-14,17H,3,6-7,10-11H2,1H3,(H,21,22)
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n/an/a 176n/an/an/an/an/an/a



UniversitÓ degli Studi di Parma



Assay Description
Membrane fractions were prepared from Wistar rat brain homogenates, and FAAH activity were assayed by using [3H]anandamide (anandamide[ethanolamine-3...


ChemMedChem 1: 130-9 (2006)


Article DOI: 10.1002/cmdc.200500017
BindingDB Entry DOI: 10.7270/Q2XG9PRC
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Ligand-Target Pair